Josh Denny
@jdnashville
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Informatician/internist, prior Vanderbilt faculty, now with NIH All of Us Research Program. All views expressed are solely my own and not necessarily the NIH.
Joined August 2011
Congrats to @zeng_chenjie & team in my @NHGRI lab & @HopkinsMedicine for this paper using @AllofUsResearch, showing that most of the ~10 million CFTR heterozygotes in the US are not at risk for CF-related disease. It also includes a PheWAS for genetically-defined CF.
Most CFTR heterozygotes in this genetic association study showed no increased risk of cystic fibrosis-related diseases compared to noncarriers. https://t.co/N7iJHuFxXd
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Atul was brilliant multitalented scientist, leader, and friend. I struggle to recall a mental image of him in which we wasn’t smiling. He would always respond to an email or call, and give of that infectious positivity and creativity - even until the end. I will miss him.
Between alarms and sheltering, I learned last night that my postdoc mentor, Professor Atul Butte @atulbutte, has passed away, and he is only 55 years old. This is devastating news 💔. Atul was a giant in so many ways. He was a visionary leader in translational bioinformatics
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Tam Tran's PheTK paper as a faster, easier way to do PheWAS in biobanks is out: https://t.co/0xVHoq7CMH. It supports phecodeX and phecode 1.2. See code that demonstrates use in a shared All of Us workspace in the researcher workbench:
academic.oup.com
AbstractSummary. With the rapid growth of genetic data linked to electronic health record (EHR) data in huge cohorts, large-scale phenome-wide association
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Prevention requires bold & forward-thinking investments. My OpEd on why letting funding lapse for @AllofUsResearch would be a step backwards https://t.co/ktGsH6yS6V
@statnews
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Today we announce the submission to #ClinVar of >32,000 variants evaluated for the return of hereditary disease risk in the @AllofUsResearch cohort. Its wonderful to return value to those who contribute their data to biomedical research! More details here:
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Excited to share @AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in @Nature
https://t.co/ph5Cd2Tq6I
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The All of Us Research Program in the Office of the Director (OD) is seeking motivated and qualified candidates for a Senior Data Science Strategist position! For more information and how to apply, visit: https://t.co/xCHdH4wdjN Closes March 1, 2024.
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If in #UX, please consider applying for @allofusresearch CXO, one of the largest, most diverse medical research cohorts in the world! #UXjobs
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As 2023 comes to a close, we are celebrating an important milestone! 750K have enrolled in the @AllofUsResearch Program. 🥳 The data they share is powering 8,150+ research projects by over 8,000 researchers! Thank you to our participants for supporting research 👏 #JoinAllofUs
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VA’s Million Veteran Program just made history—and thanks to the more than 1,000,000 Veterans who’ve joined so far, MVP is helping to build the future of health care. Learn more or join today at https://t.co/JAsz3Y95Z2.
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Lowering salt (one teaspoon) in the diet among middle-aged and older adults was as good an effect for reducing BP as a first-line anti-hypertensive drug, independent of severity of HTN or meds, in ~75% of people, from a randomized trial https://t.co/hIsY3rVXPa
@JAMA_current
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Out in AJHG - large-scale return of sequencing results for >16,000 participants shows 44% received services in 1 year and modest mean $ increase in labs, procedures ($149). Many thanks to all our collaborators! https://t.co/WVEefO2RBj
@JacksonJodell @eMERGENetwork_
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It was great work, @TACGeneMD, and a real pleasure to work with you. Next step - try it out in practice! 😀
Excited to share our recent publication in @GIMJournal. An exploration into the PheRS as a diagnostic aid. Big thanks to @jdnashville and @lisa_bastarache for their excellent mentorship on this project. https://t.co/5Ry0U4hZKp
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Come work with us & make a major impact in vision research nationally! @NatEyeInstitute is recruiting a Director for our extramural science programs (directs & manages our grant portfolio = 80% of our $896M budget). Details: https://t.co/dDQEyrTMzg
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I (personally) and @genome_gov (more broadly) are highly enthusiastic of the NIH @AllofUsResearch Program. The program’s plans to enroll and study 1 million or more participants offers tremendously exciting opportunities for genomic medicine and precision health research. 🧵:
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Loving the @AllofUsResearch program meeting. One of the participant researchers asked for a subtle but powerful change in language. #blm #DEIC #engagement
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I highly recommend everyone to join this historic and one-of-its-kind precision medicine research program. Over 600K people have signed up. We're looking to get to 1M! @AllofUsCEO @AllofUsResearch
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New paper alert! How we used a risk management approach to bring All of Us data to the research community. @AllofUsResearch @jdnashville @shidebaobaoyeah @zhiyu @eugvo @liu_yongtai @kantarcioglu @lnyemba @paul_a_harris @melissabasford1
academic.oup.com
AbstractObjective. The All of Us Research Program makes individual-level data available to researchers while protecting the participants’ privacy. This art
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I was diagnosed with #lobular #breastcancer after doing all the "right" things. #bcsm #joinallofus #reasons4research #lobmob
https://t.co/bDX82KWVwU via @usatoday
usatoday.com
I lost my mother to breast cancer when I was 13, and she was only 40. At age 19, I felt the first of many lumps in my breasts.
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Major new @NIH recruitment: Director, NIH Center for Information Technology – a critical NIH Institute with approximately 1250 employees and a $400M annual budget. Position details and how to apply: https://t.co/OnlQMpJtnr
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