Haotian Du
@HaotianDu4
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Joined May 2022
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens. TRACeR for MHC-I: TRACeR for MHC-II: @HaotianDu4 @ljjchem @SgourakisLab @StanfordBiosci @UPennAllergyImm @CHOP_Research
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TRACeR story was rejected by the same Science editor before, which is ok, but the fact that 2/3 new papers did not mention or cite us made me very sadš.I left academia, I donāt need Science paper, but I need our contribution to the field to be properly credited and recognized.
Imagine teaching immune cells to precisely target diseased cells and ignore healthy ones. šÆ Using deep learning, weāve designed de novo proteins that can distinguish small differences on the surface of cells through MHC molecules. This work is out now in @ScienceMagazine!. š§µ.
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Congratsš¤© @ginaelnesr.
Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics?. @HWaymentSteele and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!. š§µ
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RT @PossuHuangLab: New preprint from our group! We propose SHAPES, a set of metrics to quantify the distributional coverage of generative mā¦.
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RT @hphan95: Excited to share my latest first-author manuscript, now available as a preprint on @biorxiv_immuno! We introduce VLP-Open HLA,ā¦.
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Thanks @MEBirnbaum and lab for the great perspective on TRACeR papers!.
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Excited to share that TRACeR stories are outš.
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens. TRACeR for MHC-I: TRACeR for MHC-II: @HaotianDu4 @ljjchem @SgourakisLab @StanfordBiosci @UPennAllergyImm @CHOP_Research
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RT @_RongL: New online in @NatureBiotech: Specific binders to peptide-MHC class II are rapidly generated without laborious screening, by @Hā¦.
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RT @_RongL: Another work from @PossuHuangLab by @HaotianDu4 et al. : A protein platform rapidly develops peptide-focused MHC class I binderā¦.
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RT @NatureBiotech: A general system for targeting MHC class IIāantigen complex via a single adaptable loop https://ā¦.
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RT @SgourakisLab: Proud to unveil TRACER-I, a de novo protein platform developed through 5 years of collaboration with @PossuHuangLab. Byā¦.
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RT @PossuHuangLab: 1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens. TRACeR fā¦.
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RT @PossuHuangLab: Our all-atom generative model is out now in @PNASNews! Check out the lab github for the most up-to-date models and methoā¦.
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RT @SynBioGaoLab: Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-ā¦.
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RT @alexechu_: Had fun putting together this review! Lots of good surveys of the literature lately so mostly we used it as a chance to lookā¦.
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RT @PossuHuangLab: Our sequel review paper titled āSparks of function by de novo protein designā is now out in @NatureBiotech! . @alexechu_ā¦.
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Huge thanks to @ljjchem for handling most of the heavy lifting wrap up work, especially the design part! Thanks to Mellins lab and Garcia lab for collaboration and support!ā¤ļø There will also be another story on TRACeR coming out very soon! Stay tunedāŗļø.
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