Leconte Research Group
@GroupLeconte
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We are an undergraduate research group focused on protein engineering at the Claremont Colleges. We have a Twitter account now! I regret it already.
Claremont, CA
Joined December 2019
Super excited and grateful for this support from RCSA! This is a project dreamt up during the pandemic with @MadisonSeto1 (SCR '21) and started in the lab by Ysabel David (SCR '25). Very excited to have this support to fully explore this new fun direction for us!.
RCSA has chosen 11 accomplished researchers to receive its Cottrell Plus SEED (Singular Exceptional Endeavors of Discovery) Awards for 2024. The award supports members of the #CottrellScholar community in high-impact research activities.
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Clair Colee (recently graduated student) and I wrote a short primer on Directed Evolution! It is a 4-6 hour read to introduce young grad students/senior undergrads to the fundamentals of the field. Please read and share and get the word out!
pubs.acs.org
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Excited to see @taiawu's work in @GestwickiLab in print! A truly beautiful story that has been fun to watch develop. Not only did Taia publish the big fancy paper (, but she published companion works on the method and software so it is useful to others!.
pubmed.ncbi.nlm.nih.gov
Differential scanning fluorimetry (DSF) is a technique that reports protein thermal stability via the selective recognition of unfolded states by fluorogenic dyes. However, DSF applications remain...
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Congrats to @whit_lieberman who received an F31 fellowship from the NIH! The award supports her ongoing PhD work with @CKadoch at Harvard. Congrats, Whitney; the recognition is well-deserved!!.
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New paper from our group! Here, we use a high-throughput approach to identify 70 novel red-shifting mutations of luciferase. Congrats especially to the nine undergraduate student co-authors on the project!
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My department is looking for a visiting faculty member who will teach Biochemistry with us next year! This is a great opportunity for someone interested in a PUI to get some experience (I'll teach you everything that I know). Please share far and wide!
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Excited to share a preprint for this project: @MadisonSeto1, @taiawu and I wrote a guide to provide simple, usable, PRACTICAL advice for more inclusive, equitable, and effective hiring of researchers in labs. Comments and sharing are VERY encouraged!
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Check out our latest pre-print! In this paper, we describe new high-throughput biochemical techniques to study firefly luciferase, and we use this approach to make some interesting discoveries about the mechanism of color determination.
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Congrats, David! My first undergraduate mentee is out there winning awards. This is really cool to see you still doing really exciting science after all these years!.
Incredibly grateful for @PCF_Science for graciously supporting our work and @DrPaulNguyen @VanAllenLab and @MtkingMD for their wonderful mentorship!.
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Congrats to lab alum @cayditty (SCR '19) on publishing this review article! The article discusses creating and applying aqueous droplets that can stably exist in water. It was really interesting to learn about this new-to-me field! Nice work, Caitlyn!.
Our contribution reviewing interfacial stabilization strategies in aqueous two-phase systems (ATPS) is out now in @RoySocChem Materials Advances. Congratulations to graduate student authors Caitlyn Fick (@cayditty) and Zara Khan! .@samanvaya @UclaCBE .
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Such a treat and an honor to be invited by former students (@SusannaBar2 and Marya Ornelas) to give a seminar at UIUC! I even got to see the exact corn plot where the Illinois Long Term Selection Experiment is ongoing (been evolving corn since 1896 on this plot of land!).
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The latest chapter in Marya Ornelas' (PIT '20) work in the @angadmehta lab! This work further explores platforms that can be used to develop drugs and vaccines against emerging viruses. This is the third Leconte Lab alum first author paper this week!!
pubmed.ncbi.nlm.nih.gov
The constant and the sudden emergence of zoonotic human and animal viruses is a significant threat to human health, the world economy, and the world food supply. This has necessitated the development...
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I guess I should have said: Freddy is Pitzer class of 2014 and one of the original members of my group!.
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Another groundbreaking paper from @FreddyMValencia and @CKadoch that thoughtfully blends genetics and biochemistry. So cool to see this in print since I remember when Freddy was an undergraduate telling me that he wanted to make an impact in this field!
nature.com
Nature Genetics - Genes encoding members of mammalian SWI/SNF (BAF) complexes are frequently mutated in individuals with neurodevelopmental disorders (NDDs). Mutant NDD residues include some unique...
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New paper from lab alum @whit_lieberman! A really elegant approach to sensing Ac-CoA in complex samples (plus it is always fun to see alums using luciferase after leaving our lab).
pubmed.ncbi.nlm.nih.gov
Chemoproteomic profiling is a powerful approach to define the selectivity of small molecules and endogenous metabolites with the human proteome. In addition to mechanistic studies, proteome specifi...
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Congratulations to lab alum Ellery Koelker-Wolfe (CMC '19) who was awarded a prestigious NCAA Postgraduate Fellowship! This award supports her ongoing MD at Harvard and recognizes her excellence on the basketball court, the classroom, and the research laboratory! @CMCnews.
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So grateful for this support from @RCSA1 ! We are super excited to have Marcell Simon (PIT '23) for a postbac experience in the coming year!.
Seven #CottrellScholars have received Cottrell Postbac Awards in the 2nd year of a post-pandemic initiative to support the work of an undergraduate senior working under their supervision for a year after graduation.
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Congrats to lab alums Madison Seto (UCSF, Wells Group, awarded NSF GRFP!) and Whitney Lieberman (Harvard, Kadoch Group, Honorable Mention for NSF GRFP!). We are proud of you and excited to see all you discover in grad school and beyond!.
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The Leconte Lab is on the move to this week's ASBMB in Seattle! Check out Ysabel David, Hailey Kang, and Celia Fritsch presenting on poylmerase project, Clair Colee and Reema Iqbal presenting on the luciferase project, and Abe Vasquez presenting on his summer work at UCSF!.
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RT @ChemBioChem: Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools (Prescher, Leconte) @UCIchemistry @UCIbiosci #opena….
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