Sigrid Gouma
@GoumaSigrid
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Scientist who loves viruses and vaccines. Views are my own.
Leiden, Nederland
Joined May 2020
We just published another flu mRNA vaccine study in @JVirology, where we show how the mRNA vaccine platform can improve seasonal influenza vaccines. 1/2 https://t.co/CxUPRLrubm
journals.asm.org
This study shows that the nucleoside-modified mRNA-LNP vaccine platform is a promising alternative for egg-based influenza vaccines. We show that mRNA-LNP vaccines expressing H3 antigens elicit high...
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Being pregnant myself, I am very happy that our study on placental antibody transfer after COVID-19 vaccination was published today!
Our @PennMedicine and @ChildrensPhila collaborative study was published today showing that neonatal SARS-CoV-2 antibodies are higher following maternal vaccinations rather than maternal infections, with @karen_puopolo @dus10flan @GoumaSigrid and team: https://t.co/UMgVf519Tm
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Our manuscript evaluating mRNA-based H3N2 vaccines in mice was posted on bioRxiv. Most of these studies were completed before the pandemic, and it is nice to finally get this one out. 1/6 https://t.co/49wcOKBf0Y
biorxiv.org
Most human influenza vaccine antigens are produced in fertilized chicken eggs. Recent H3N2 egg-based vaccine antigens have limited effectiveness, partially due to egg-adaptive substitutions that...
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Exposure to SARS-CoV-2 measured by serostatus (pre-vaccine era) was not associated with hypertensive disorders of pregnancy @AJOG_thegray @dus10flan @karen_puopolo @MDhudasia @GoumaSigrid #preeclampsia #covidinpregnancy
@JourdieTMD Seems the COVID-19 and HDP story is more complex than meets the eye.
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Neighborhood characteristics as contributors to seropositivity in Philly. @annemullin7 is an amazing analyst & @TuftsMedSchool student and @karen_puopolo a wonderful sponsor & thx to @SCOTTeHENSLEY @dus10flan @sagori @DrDianaMW and team!
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Antibodies come and go, but memory cells are forever (maybe not forever, but at least 6 months). Our latest in @ScienceMagazine: https://t.co/YHHBMrMsTA How long does immune memory last after #mRNA vax? Is it effective vs. variants? What about “boosted” responses? Full 🧵⬇️...
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Have questions around #COVID19 #vaccines? Email our team at sciencesuperfriends@gmail.com for our team of scientists to address your questions! https://t.co/IXtKgzqozv
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Zika Virus Antibody Titers Three Years after Confirmed Infection https://t.co/xJmrKyC4Vx via @MDPIOpenAccess
mdpi.com
Background: In 2015–2016, a large Zika virus (ZIKV) outbreak occurred in the Americas. Although the exact ZIKV antibody kinetics after infection are unknown, recent evidence indicates the rapid...
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Just Published: Health care worker sero-monitoring reveals complex relationships between common coronavirus antibodies and #COVID_19 symptom duration: https://t.co/uFAtIQ0aDj
@SCOTTeHENSLEY @PennMedicine
#Immunology
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Paper published ✅ It took lots of blood, sweat, (tears?) and (weekend) hours from many @SCOTTeHENSLEY lab members and others to collect all data, so I am excited to see the results being published in @JCI_insight: https://t.co/W92mcx4eRD
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Excited to share our latest preprint on #SARSCoV2 #mRNA vaccine responses of MS patients on aCD20 B cell depleting tx. We evaluated in-depth antigen-specific B cell and T cell responses to better understand the vaccine-induced immunity in these patients. https://t.co/QoRvB4iHWo
medrxiv.org
SARS-CoV-2 mRNA vaccination in healthy individuals generates effective immune protection against COVID-19. Little is known, however, about the SARS-CoV-2 mRNA vaccine-induced responses in immunosup...
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After 4 unforgettable years as a postdoc with @SCOTTeHENSLEY at @Penn I am looking forward to my next scientific adventure at Janssen Vaccines & Prevention 🇳🇱.
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Just finished my last SARS-CoV-2 ELISA in the Hensley lab. Not sure if I’ll miss the ELISAs 😉, but I will miss all incredible lab members and collaborators within and outside Penn! It has been a pleasure to work with all of you on so many different flu and SARS-CoV-2 projects.
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Tune in to the upcoming @LSuperfriends webinar to learn more about COVID-19 vaccines and emerging SARS-CoV-2 variants, see info below.
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A study of hospitalized patients with liquid or solid #cancer who were infected with #SARSCoV2 suggests that hematologic malignancy is an independent risk factor for mortality and that CD8+ T cells might limit infection irrespective of humoral #immunity. https://t.co/iPjIAC0uqA
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