Zinaida Good
@GoodZinaida
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Assistant Professor of Medicine at Stanford University
Palo Alto, CA
Joined December 2014
Excited to present the first major work after starting our lab at Stanford and the Arc this year: CRISPR-All, a unified genetic perturbation language for programming any major type of genetic perturbation simultaneously, in any combination, at genome scale, in human cells.
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We're excited to release tcellMIL, an attention-based multiple instance learning model for predicting patient outcomes after CAR T cell therapy for lymphoma and nominating cell design strategies in #neurips2025 AI4D3!
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It's exciting to share our mini-review on #Treg cell therapies out today in Frontiers in Immunology! Earning a #NobelPrize this year, Tregs have been tested in >69 clinical trials and are moving towards initial approvals.
frontiersin.org
Regulatory T cell (Treg) therapies are emerging as powerful tools for treating autoimmune and inflammatory diseases, preventing graft-versus-host disease (Gv...
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This would not be possible without my mentors, especially Crystal Mackall, @sylviaplevritis, @GarryPNolan, Sean Bendall, David Miklos, and Michael Gold - THANK YOU!
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Today is my first day as an Assistant Professor of Medicine at Stanford University! My research program is focused on understanding and enhancing engineered T cell immunotherapies for cancer and immune-mediated diseases. If interested in joining please reach out!
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Very proud of Anne Marijn Kramer to present 2 orals and a poster at #ASH2024, especially our work on CD22-CAR! Session 702 Dec 9 at 2:45 PM San Diego Convention Center, Room 6CF Title: CD22-Directed CAR T Cell Single Cell Multiomic Features Associated with IEC-HS
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So proud of Kelvin Mo to give his first talk at #ASH2024! Session 702 Dec 7 at 4:00 PM Manchester Grand Hyatt San Diego, Grand Hall C Title: CCL8/CCL13-Producing Tumor-Associated Macrophages Linked to Poor Outcomes after CAR T Cell Therapy for LBCL
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What an honor to give my first invited talk at #ASH2024. I am so grateful to my mentors Crystal Mackall, Sylvia Plevritis, and David Miklos for enabling me to get here! Dec 8 at 4:30 PM, San Diego Conv. Center, Room 33 Cellular Heterogeneity and Relationship to Clinical Outcomes
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Our Stanford Center for Cancer Cell Therapy is excited to offer a Postdoctoral Fellow position at the interface between machine learning and T cell therapies:
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Boom Capital is hiring a Chief of Staff. 🚀 This is one of our most important hires. You'll liaise with our in-house scientific society and impact every aspect of a VC firm, serving unprecedented ideas, scientists and engineers. Join https://t.co/30lUgMZk1b and apply here:
boomcap.co
Seeking Scientist-Protagonists
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Grateful to give an invited talk at the 6th Annual #Treg-Directed Therapies Summit! Please join us in Boston this May 21-23. https://t.co/7gzWIYGwVP
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Humbled and grateful to be selected as a 2023 Bridge Fellow by the @parkerici to push forward CAR T immunotherapy research.
parkerici.org
Since 2016, PICI has provided more than $20 million to 45 emerging researchers to transform their bold questions and big ideas into treatment advancements for patients. SAN FRANCISCO, CA – Powered...
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Grateful to @CGT_Live to publish this summary of our work with @MackallLab, David Miklos, @BitaSahaf and team that I presented at @AACR!
cgtlive.com
The investigators created the largest known CAR-T atlas, with more than 800,000 cells in total, providing a new exploration into the phenotyping of T-cells.
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Honored to be interviewed by @10xGenomics to discuss our work with @SRamakrishna_MD , @MackallLab, and @michelle_monje on GD2-CAR T cell therapy for pediatric brain cancer.
#CART therapy is a good treatment for blood cancers, and @SRamakrishna_MD and @GoodZinaida think it has potential for kids with fatal brain cancer, too. Hear more about their #singlecell study, in collaboration with @parkerici, in our latest blog post ⬇️
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Thanks @TeikoBio for highlighting our work with @jayspiegel25, @BitaSahaf, @MackallLab, David Miklos, and team on defining the role of CAR Treg cells in progression following #CART therapy for lymphoma.
Axi-cel is effective in only 40% of large B cell lymphoma (LBCL) patients and 69% experience neurotoxicity. Using mass cytometry, @GoodZinaida et al profiled post-infusion CAR T cells in LBCL patients to identify markers of response and neurotoxicity.
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Thanks to @statnews for covering our work identifying CAR Treg cells as limiting efficacy, toxicity, and expansion of CD19-CAR in lymphoma. Full article in @NatureMedicine here: https://t.co/eXErZXEAQs.
statnews.com
“As you engineer your CAR-T cells, you can make sure they’re not fighting against each other,” a cancer researcher suggests in light of new findings.
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To accelerate development of effective T cell therapies for cancer, there's an urgent need to decipher the attributes of the ideal therapeutic T cell Read the Meeting Report from the Parker Institute & 10x Genomics @SamanthaBucktr1 @parkerici @10xGenomics
https://t.co/UKG6JlZafY
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In collaboration with @parkerici scientists and @10xGenomics, we wrote a commentary on "Advancing T cell–based cancer therapy with single-cell technologies" just out in @NatureMedicine:
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We're grateful to @BitaSahaf and the whole #CCSU for enabling correlative studies like this.
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Single-cell proteomic profiling of circulating #CART cells in patients treated with CD19-CAR shows that CD4+Helios+ CAR #Treg cells on day 7 after infusion are associated with progressive disease & less severe neurotoxicity in patients with #LBCL. https://t.co/xteFBA31SP
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