Gabel Lab
@Gabel_Lab
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Lab of Harrison Gabel, at Washington University in St. Louis. Studying epigenetic mechanisms in the brain.
St Louis, MO
Joined August 2016
Proud to report our newest paper with @McAlinden_Lab. Great WashU collaboration! Wonderful work by @AustinBellHens , @dianasaurus7, and the whole team.
Fantastic collaboration with @Gabel_Lab @WUSTL resulting in this new @Els_BoneEndo publication reporting skeletal defects in #Dmmt3a mutant 🐁 spearheaded by @AustinBellHens and @dianasaurus7 Great team work!! #collaborativescience.
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RT @McAlinden_Lab: Fantastic collaboration with @Gabel_Lab @WUSTL resulting in this new @Els_BoneEndo publication reporting skeletal defect….
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Check out our latest on how specialized neuronal DNA methylation and MeCP2 collaborate with unique long gene structures to help maintain diverse cell-type-specific transcriptomes in the brain! .
biorxiv.org
The extraordinary diversity of neuron types in the mammalian brain is delineated at the highest resolution by subtle gene expression differences that may require specialized molecular mechanisms to...
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. and the hits just keep on coming! Congrats to lead author Diana (@dianasaurus7) and her coauthors on there comprehensive new study of distinct disease-associated DNMT3A alleles and their impact in vivo.
biorxiv.org
Phenotypic heterogeneity is a common feature of monogenic neurodevelopmental disorders that can arise from differential severity of missense variants underlying disease, but how distinct alleles...
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New paper from our lab linking MeCP2 to topoisomerase regulation! Congrats to lead author Sabin Nettles and her coauthors on a great study!.MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes
biorxiv.org
A unique signature of neuronal transcriptomes is the high expression of the longest genes in the genome (e.g. >100 kilobases). These genes encode proteins with essential functions in neuronal...
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Excited to present our new study on mechanisms governing deposition of neuronal DNA methylation and their disruption in neurodevelopmental disorders. Congrats to first authors Nicole Hamagami and Dennis Wu, and all our co-authors.
biorxiv.org
During postnatal development the DNA methyltransferase DNMT3A deposits high levels of non-CG cytosine methylation in neurons. This unique methylation is critical for transcriptional regulation in the...
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RT @yaochen20: Interested in building cool things for neuroscience discovery? Apply to be the first engineer where you will have a major im….
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Congratulations @Katz_Lab!!!.
CONGRATULATIONS to my wonderful Cell Bio colleagues/mentors @Katz_Lab and @LabLerit @EmoryMedicine on these incredible achievements!!! 🍾
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Excited to share our study @Nature led by @xiaoyingchen36 and in collaboration with labs of @SamWangPhD, Xiaoqing Chen, and others, uncovering transcriptomic plasticity in a subpopulation of Purkinje neurons linking sensory experience to learning!.
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RT @ChengHuangThu: I’m overjoyed to announce that I will join the Department of Neuroscience at Washington University School of Medicine in….
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RT @ErikHerzog: Got kids who want to know "what is a neuroscientist?" Starring (not actors) @HombreCerebro @yaoch….
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Great new work from the Yi Lab and colleagues dissecting the functional effects of UBE3A mutations! A tour-de-force going from functional effects of mutations, to structural insights, to impacts in vivo! Congrats!.
The first paper from the lab is out! Huge effort from @KellanWeston, @zhaojh1928, and Renee Gao in our lab with a big assist from our @WUSTLmed collaborators @Suz_Maloney and @marshinawi.
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RT @TBRSCommunity: BIG NEWS! The Tatton Brown Rahman Syndrome Community has been selected to join the Rare As One Network!.
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RT @WUSTLneurosci: Congratulations to Sabin Nettles @NettlesSabin, who receives this year's Next Generation Award from @SfNtweets! Read abo….
neuroscience.wustl.edu
Nettles is a graduate student in Harrison Gabel’s lab in the Department of Neuroscience at Washington University School of Medicine.
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RT @willrenthal: We are recruiting creative postdoctoral fellows and research assistants to the lab at @BWHNeurology @harvardmed to explore….
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RT @gary_ruvkun: Recruiting for small RNA projects, electron transport chain and iron-sulfur cluster genetics (w Mootha lab), aging, bacter….
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We are recruiting faculty! Come join a great department!.
We have faculty positions available for neuroscientists at assistant/associate and tenured professor levels. Join us as we get ready to move into our fabulous new #neuroscience research building, under construction. #neurotwitter .
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RT @AzadBonni: Pleased to highlight new study from @Gabel_Lab and my lab led by @NaveenCReddy2, Shahriyar Majidi, &….
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RT @WUSTLneurosci: Our department donation drive to @iistl generated these items + $1,755 to support Afghan refugees coming to STL. Thank y….
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Congrats @NettlesSabin!.
Congratulations to @WUSTLdbbs's own Sabin Nettles @NettlesSabin (@Gabel_Lab), recipient of the 2021 Pre-/ Post-Doctoral Next Generation Award from the Society for Neuroscience (@SfNtweets)! Well done! .Read more here: #DBBSProud #BlackinSTEM #WomeninSTEM
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