Yao Chen
@yaochen20
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🧠 Curious about neuromodulator interactions or how sleep works its magic? Apply to our lab @WashUMedNeuro as a postdoc to bridge cellular & systems neuroscience by decoding biochemical signaling dynamics in the brain! Please RT. #Neuroscience #PostdocOpportunity #BrainResearch
🚨Job Alert 🚨 Postdoctoral Research Associate (Chen Lab) @yaochen20’s interdisciplinary lab in the Department of Neuroscience at WashU Medicine seeks a motivated postdoctoral researcher to join the team. Learn more and apply: https://t.co/NSgK8l507y
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Our latest led by @TVKamath with important contributions by collaborators including Nao Uchida, Mitsuko Watabe-Uchida and @LinTianPhD Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum: Neuron
cell.com
Kamath et al. examine the neural mechanism by which hunger makes animals take more risks. They show that hunger neurons in the hypothalamus suppress threat and salience-related dopamine signals in...
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We are very excited to announce our new study https://t.co/GUd34dYx3Q led by recently minted PhD @RichieHakim. He first developed FaceRhythms to break down videos of facial behaviors into interpretable spatial-spectral components and then showed that these are highly ...
biorxiv.org
Animals, including humans, use coordinated facial movements to sample the environment, ingest nutrients, and communicate. To study these behaviors and the neural signals that underlie them, we...
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Big thanks to co-authors @PC_Ma93, Peter Chen, and @BrainCaRMA for the adventure together! Grateful to the editors and reviewers for their valuable feedback! If anybody has questions or feedback after using our package, please get in touch.
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Our paper simulating fluorescence lifetime in real-life experiments is now a Version of Record @eLife! We hope it helps FLIM users with more rigor and innovation. If you are interested in turning our innovation proposals into reality, we welcome motivated people to join our lab.
Revised manuscript in @eLife: The promise and peril of comparing fluorescence lifetime in biology revealed by simulations
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Revised manuscript in @eLife: The promise and peril of comparing fluorescence lifetime in biology revealed by simulations
elifesciences.org
A versatile computational framework realistically simulates fluorescence lifetime data in biological systems, enhancing rigor by quantifying signal variance and identifying limitations, and enabling...
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Can synapses in the brain switch their signs between excitatory and inhibitory during learning🚦? Can they act more like weights in artificial neural networks, able to switch signs based on experience 🔃? Excited to share my thesis work in @blsabatini lab! 🧵 ⬇️ (1/13)
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Excited to share new work from our lab, John Assad + @blsabatini! We show reward-related signaling of dopamine (DA) neurons exerts one-shot calibrating updates to movement timing—a measure of vigor. #Dopamine #Neuroscience @WhiteheadInst @harvardmed
https://t.co/FiuUTcgkbb
biorxiv.org
Dopamine neurons (DANs) play seemingly distinct roles in reinforcement,[1][1]–[3][2] motivation,[4][3],[5][4] and movement,[6][5],[7][6] and DA-modulating therapies relieve symptoms across a puzzling...
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📣📣 Exciting opportunity to present your work at Vanderbilt! Please apply and help me spread the word!
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We have an updated version of our fluorescence lifetime simulation manuscript now: https://t.co/wKjwh6zrcd. We have included a Python version of the package in addition to the original Matlab package. We hope this is useful for the community and welcome feedback.
biorxiv.org
Signaling dynamics are crucial in biological systems, and biosensor-based real-time imaging has revolutionized their analysis. Fluorescence lifetime imaging microscopy (FLIM) excels over the widely...
Our paper, "The promise and peril of comparing fluorescence lifetime in biology revealed by simulations", is now on @eLife: https://t.co/cASRJYO5wb. Hope readers will use our package to design and interpret FLIM experiments rigorously, and also give us feedback.
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Excited to start a new lab at Florida State University this summer! @PsychologyFSU @FSUNeuroscience We’ll study how the brain enables generalization to support decision-making in novel situations. https://t.co/QM0xDCYcr5 We’re recruiting—please RT or share with anyone interested!
kiralab.org
Our long-term research goal is to understand how the brain uses past experiences to make decisions for “novel” situations – a process known as Generalization
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Congrats to Kim Reinhold, soon to launch her own group in the Eaton Peabody Labs, on this labor of love. Basically, she shows that the visually recipient zone of the striatum mediates outcome-dependent trial to trial updates of behavior. https://t.co/kDSBN1yRdf
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1/ Why do late-stage cancer patients lose motivation & sink into apathy? 🔥Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu @sarahstarosta @Pignatelli_Lab @JanowitzTobias &team!🧵 🔗
science.org
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical...
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Why do individuals with late-stage cancer sometimes struggle with motivation and experience profound apathy? In this multi lab effort @KepecsLab @JanowitzTobias and my lab we are tackling this question 👇🏻 😊
science.org
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical...
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We are looking for a new lab manager. It's a demanding job but an exciting one with lots of room for growth as a scientist and manager. Consider applying even if you are currently a senior tech but interesting in moving into a lab manager position. https://t.co/h5kQuanz5m
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Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs. https://t.co/FiMz73xJAV
nature.com
Nature - A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance,...
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🚨New paper out!🚨 Excited to share the latest from our group. This 5yr long odyssey was led by Susan @DutcherLab and Steve Brody @slbzz. We address a key question: why do some PCD patients develop more severe lung disease than others? Check it out 👇 https://t.co/xHrFL51bcD
science.org
CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.
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🚨Job Alert 🚨 Postdoctoral Research Associate (Chen Lab) @yaochen20’s interdisciplinary lab in the Department of Neuroscience at WashU Medicine seeks a motivated postdoctoral researcher to join the team. Learn more and apply: https://t.co/NSgK8l507y
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Join us for the Modulation of Neural circuit GRC this May!
Modulation of Neural Circuits and Behavior GRC is nearly 100 days away! Check out the amazing list of speakers and join us for a scintillating series of talks!
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