RT @Jun_kiim: Just published in @Nature, Clements et al. reveal that axonal injury is a key driver of early GBM progression, overturning th….

4/4 This study expands the understanding of the interplay between tumor metabolism and epigenetic remodeling in T-ALL and offers new clues for developing combined metabolic–epigenetic therapeutic strategies against this disease.

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3/4 The development and application of high-precision single-cell ChIP-seq technology enable multidimensional synchronous analysis of histone modifications such as H3K18la, which will provide critical insights for deciphering the combinatorial functions of these modifications.

2/4 By focusing on the interaction between H3K27ac and H3K18la, the research emphasizes that transcriptional regulation in tumors constitutes a complex system integrating multiple histone modifications.

1/4 This study elucidates how metabolic reprogramming profoundly influences epigenetic remodeling through histone lactylation, participates in the transcriptional regulation of key driver genes in T-cell acute lymphoblastic leukemia (T-ALL), and thereby promotes leukemogenesis.

🎉🎉🎉The research article published online in GPB, reveals the regulatory role of histone lactylation in mediating transcriptional dysregulation in T-cell acute lymphoblastic leukemia. #GPB #histone #ALL #bioinformatics

6/6 These findings provide new insights into the relationship between gene arrangement, transcriptional regulation, and functional evolution. They also offer valuable clues for studying human evolution, brain development, and the genetic basis of population diversity.

5/6 Differences in DPGs between European and Chinese reference genomes suggest their potential role in shaping population-specific traits.

4/6 Phylogenetically conserved DPGs in primates primarily maintain fundamental cellular processes, while human-specific DPGs (e.g., SRGAP2–FAM72) are likely involved in shaping human-specific neurodevelopmental traits.

3/6 Their co-expression levels are tightly regulated by the distance between transcription start sites (TSS) and epigenetic features, including chromatin accessibility and histone modifications.

2/6 DPGs are widely conserved across vertebrates and are particularly enriched in core “binding” functions and cell cycle synchronization processes.

1/6 This study employs large-scale cross-species and multi-omics analyses to systematically characterize the evolutionary conservation landscape, functional interaction networks, and precise regulatory mechanisms of human divergently paired genes (DPGs).

Genomics, Proteomics & Bioinformatics (GPB) has published a paper online entitled “Lineage-associated Human Divergently-paired Genes Exhibit Structural and Regulatory Characteristics”. Let’s explore the collaborative code of “neighboring genes” in the human genome. #DPG

3/3 The submission deadline for this special issue is March 31, 2026.We welcome the submission of various article types, including Reviews, Resource Articles, Perspectives, Original Research, Methods, Databases, Web Servers, and Software Applications.

2/3 We welcome original contributions that address efficient collection, intelligent modeling, accurate analysis, and innovative applications of clinical omics data.

1/3 Aiming to overcome the bottlenecks in acquisition and analysis of large-scale clinical omics data, this special issue highlights cutting-edge research on the deep integration of artificial intelligence (AI) and biotechnology (BT).

Genomics, Proteomics & Bioinformatics (GPB) invites submissions for a special issue entitled "AI + BT for Big Clinical Omics Data", tentatively scheduled for publication in Fall 2026.🎆🎉 #special_issue #AI #BT #bigdata

3/3 The team has established a user-friendly and fully functional online platform (, providing users with a one-stop experience ranging from variant query to online genotype imputation.

2/3 samples originating from populations included in the reference panel showed significantly higher imputation accuracy (P = 0.0042). This result confirms that the "genetic relatedness" between the panel and the target samples is a key factor in improving imputation performance.

1/3 Compared to commercial chickens, CMP populations exhibit a faster decay rate of LD, lower polymorphism in variation sites, and reduced haplotype diversity, reflecting a decline in genetic diversity resulting from long-term directional selection in commercial breeds.