Friml Lab
@FrimlLab
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Developmental and Cell Biology of Plants @ISTAustria
Klosterneuburg, Austria
Joined December 2022
Our study reveals a dual role for auxin: coordinating gene expression and cytoplasmic remodeling via autophagy — ensuring fast, efficient developmental reprogramming. Auxin doesn’t just permit change. It enables it. 💫
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In auxin maxima, autophagy lights up — and in autophagy-deficient mutants, differentiation slows down. Auxin doesn’t just tell cells who to become — it helps them clear the decks to become something new.
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Why does this matter? Because developmental transitions need both instruction (transcription) and space to change (autophagy). We show that auxin-induced autophagy is essential for: 🌿 Organogenesis 🌸 Progression of differentiation
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This isn’t just stress autophagy. At physiological auxin levels, TIR1/AFB receptors (and their adenylate cyclase activity) activate transcription-dependent autophagy! That means auxin couples “turning on” new genes with “clearing out” the old cytoplasmic state.
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Auxin – the master regulator of plant development – is famous for reshaping transcription through the nuclear TIR1/AFB–Aux/IAA pathway. But here’s the twist: we found that auxin also rapidly triggers autophagy — a self-cleaning process that recycles cellular material. ♻️
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🚨 New preprint by @Cate_Giannini🚨 We uncover an unexpected link between auxin signalling, transcription, and autophagy — revealing how plants coordinate gene expression and cytoplasmic renewal to drive developmental reprogramming. 🌱✨ https://t.co/W5HFo3NQNE
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Now online: A tandem of two papers showing TMK regulation of PIN-dependent auxin transport https://t.co/KXjwlRywk0 (PIN2, Friml lab) and https://t.co/SbXRU6qDpB (PIN1, Xu lab)
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For those that want to learn more about auxin, I am proud to present our latest review Mechanisms of auxin action in plant growth and development. https://t.co/CHg6AL9vga
@FrimlLab @horticell
pubmed.ncbi.nlm.nih.gov
The phytohormone auxin is a major signal coordinating growth and development in plants. The variety of its effects arises from its ability to form local auxin maxima and gradients within tissues,...
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Big celebrations for our new Doctor Huihuang Chen! Congratulations and cheers to your bright future!
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We look forward to seeing you in Palermo!!
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Pflanzen üben auf den Biologen & Wittgenstein-Preisträger Jiří Friml eine besondere Faszination aus. Er hat die Funktion des Hormons #Auxin als Vermittler zw. Umgebung und Zellkommunikation in #Pflanzen entdeckt. @ISTAustria🌿 Video-Porträt Jiří Friml ▶️ https://t.co/loQfOhfLlr
scilog.fwf.ac.at
Pflanzen üben auf den Biologen und Wittgenstein-Preisträger Jiří Friml eine besondere Faszination aus. Den Wissenschaftler interessiert die Frage, wie Pflanzen ihre Überlebensmechanismen entwickelt...
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FREE to Join | MPlant Virtual Seminar | Shifting Paradigms in Auxin Signalling | March 27, 2025 9:00-10:00 (UTC+1, Austria) | March 27, 2025 16:00-17:00 (China) | Zoom Meeting ID: 856 4424 9945 Passcode: 123789 | Welcome to join! https://t.co/XPAuCRxEVy
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@kat_kurtovic in our New Phytol: auxin has effect on regeneration in Chara braunii, at least one its PIN is PM localized with auxin-transporting activity and distribution correlated to acid bands in Chara cells. IAA application induces MAPKs within minutes https://t.co/hj3eq9zFRn
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Congratulations on your brilliant defense Aline! All the best for your future endeavours! Thanks to all the committee! Check out Aline's work on TMK1 interactors @biorxiv_plants
https://t.co/YiIIKCREKQ
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New edge to canonical auxin signalling – cAMP acts as second messenger - now on @nature
https://t.co/2KJ0v1vBLU
nature.com
Nature - cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin...
New paper by the @FrimlLab, Huihuang Chen @ISTAustria and more out in @Nature revise our knowledge about the auxin signaling mechanism in plants.
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🚅Advance Access: How polarized tissue repair is achieved upon excision? Using a bryophyte Physcomitrium patens, Han Tang et al. revealed that the proper polarization of PIN-FORMED #auxin exporter is a key process🔑 https://t.co/3jyfsZ9OM2
#cellreprogramming #plantsci
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BREAKTHROUGH REPORT: Super-resolution expansion microscopy in plant roots (Michelle Gallei, Sven Truckenbrodt, Caroline Kreuzinger, et. al.) https://t.co/LjjoZBqVrY
@ASPB #PlantSci
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Another day, another preprint from our lab! Congrats to @kulich_ivan and colleagues: here is the news on ROS burst regulation. Now on @biorxiv_plants
https://t.co/jgMspDjEsp
biorxiv.org
Reactive oxygen species (ROS) have been implicated repeatedly in multiple signaling processes in plants but the underlying mechanisms and roles remain enigmatic. Here, we developed live imaging of...
ROS bursts after auxin, RALF, eATP or mechanical bending? We monitored them all. What triggers them and what are they good for? Many surprises! Read our new preprint, a second one in a row. Thanks ISTA and Biology Centre CAS for amazing environment. https://t.co/77XmnmX0J4
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New year, new preprint from @kulich_ivan : AROs as key plant-specific players in plant CNGC function and Ca2+ signaling https://t.co/CN6o0hH5Ol
biorxiv.org
Plant cells respond to a wide range of stimuli through intracellular calcium (Ca2+) signaling. Cyclic nucleotide-gated channels (CNGCs) are a major class of plant Ca2+ channels, with 20 homologs in...
Armadillo Repeat Only proteins enable function of multiple, if not all CNGC channels. These are essential for plethoha of calcium signals triggered by stresses, hormones and pathogens. Read our new perprint. https://t.co/bhkLLKn2Zd
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Time is ticking! ⏰ The call for our PhD program ends in a few days! Apply now to join us at ISTA next fall! 🔗 https://t.co/V424G3PuuJ
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