Feltham Lab
@FelthamLab
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We smash & trash; we #PROTAC and attac 💣 We discover new drug targets & hijack the #ubiquitin system to remove them💊 Tweets by PI @BekkyFeltham @WEHI_research
Melbourne, Victoria
Joined November 2019
@FelthamLab managed to get a pic all together today. Love this one ☺️ @WEHI_research #EnjoyingScienceTogether
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Heads up for those working in ubiquitin biology and targeted protein degradation—Lorne Ubiquitin 2025 is happening 20–23 November in Lorne, Victoria, Australia. Late abstracts are still being accepted—worth checking out!!! 🦘🦘🦘
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Had an exciting morning of #TargetedProteinDegradation at the launch of Ternarx! @ternarx49306 Fantastic to have strong support from @Mark_Butler_MP and the incredible team @WEHI_research. 🔗 Explore our journey and vision: [WEHI Announcement]( https://t.co/1nFGCFRSDD)
wehi.edu.au
Australia has cemented its role in becoming a major player in the next-generation of medicines with the launch of Ternarx
Ternarx is the first biotech company of its kind in Aus. focused on developing targeted #proteindegrader medicines for hard to treat #cancers. A great partnership with WEHI, @MonashUni & @KidsCancerInst, backed by $15m in #MRFF @healthgovau funding. https://t.co/AgyNA0jqXu 🧵2/2
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🔬2024 Lab Update! 🌟 Farewell to incredible team members, @DanielSimpsonAU and Anna Gabrielyan. Wishing them success as postdocs!💙Excited for new faces and opportunities in 2024. Here's to innovation, collaboration and new discoveries🚀 #LabLife #NewBeginnings #Science2024
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Unlocking the secrets of the E3 ligase MIB2!🕵🏻♂️ Our new paper @PNASNexus unravels the mysteries of MIB2 in mice with the cpd mutation, and its unexpected role in wound healing 🐁🩹 An excellent study we're thrilled to share!#wehiresearch #MIB2Discovery
https://t.co/AC4rt1cZYL
academic.oup.com
Abstract. Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype drive
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Abstract submissions for 2024 @LorneProteins, incl. the Satellite Meeting on "Ubiquitin signalling: Molecular mechanisms, biology and targeted protein degradation" are closing soon. If you work on #ubiquitin, ubiquitin-like modifiers, #PROTACs or #TPD, we want to hear from you!
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Great talk from @mediocre_jake today talking all things E3 ligase, a favourite topic in the @FelthamLab @WEHI_research
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Well done Anna Gabrielyan for a fantastic talk for @AusCellDeathSoc @WEHI_research today. Great story and really interesting data 🤓😎
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The Vervoort and @FelthamLab @BekkyFeltham are looking for an enthusiastic Research Assistant who wants to join our labs for a year to kickstart an exciting new project on degron therapeutics in cancer. Check it out and please share:
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WEHI researcher Dr @BekkyFeltham was always intrigued by biochemistry. These days Dr Feltham heads up a #UbiquitinSignalling laboratory searching for new therapies to treat #InflammatoryDiseases Discover more in the new edition of Illuminate
wehi.edu.au
At university, Dr Rebecca (Bekky) Feltham knew there was something special about biochemistry.
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@FelthamLab Christmas Shenanigans continued @CargoRestaurant with our end of year awards. The best mistake award this year going to @BekkyFeltham #MerryChristmas
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@FelthamLab Christmas Shenanigans @archiebrothers, great afternoon of arcade game fun 😁 #festiveseason #MerryChristmas
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Well done @TamerAly_Tam for an excellent PhD confirmation seminar today @WEHI_research #PhDconfirmed #phdlife
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Paper free to read in @nchembio: https://t.co/SLYPihMSAl.
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#cIAP1-based %degraders induce #degradation via branched #ubiquitin architectures | Nature Chemical Biology
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An expanded Lexicon for the Ubiquitin code by @idikic @IBC2_GU & Brenda Schulman @MPI_Biochem 😳 New types of #Ubiquitin modifications on serine, threonine, lipids, sugars, also on ADPR..opportunities for innovative #therapeutics
https://t.co/ZmKq2iaj4d
https://t.co/uRE77AbeIP
nature.com
Nature Reviews Molecular Cell Biology - Recent studies have expanded our understanding of the mechanisms and functions of ubiquitylation. Pathogens rewrite ubiquitylation to promote infection...
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Wow!!! Congratulations @Nurix_Tx for having achieved a complete (!) response in a patient with aggressive Non-Hodgkin's Lymphoma using their using a small molecule degrader. So wonderful to see these clinical data emerge with targeted protein degradation! https://t.co/y5afQmLNHY
ir.nurixtx.com
Complete response observed and ongoing in a patient with multiply relapsed/refractory diffuse large B cell lymphoma (DLBCL) Dual BTK degradation and immunomodulatory activity achieved by day 8 and...
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A big mystery solved? Endogenous function of the CRBN Ligase revealed by Christina Woo et al @Nature!! Spoiler…it’s all about protein quality control. CRBN recognizes damaged proteins with cyclic di-peptides that mimic IMiDs! So cool👏👏
nature.com
Nature - C-terminal cyclic imides are physiological degrons that enable the ubiquitin E3 ligase adapter protein cereblon to target substrates for degradation.
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