TACT-ETN
@EtnTact
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Twitter account of the Marie-Curie-funded European Training Network 'Targeted Anti-Cancer Therapies' (Grant Agreement Number 859458).
Joined October 2020
Last week the @EtnTact squad got reunited to present each #ESRsโ project depicted in the graphics by Lison Bernet in the classy location of the Palais Universitaire de #Strasbourg and passionately introduced by our project leader @ChaubetGuilhem #Cancer
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๐จPhD Opportunity:๐จ Come and join us and @VijayChudasama_ at UCL Chemistry investigating new chemical methods for empowering antibody conjugates partnered with @GSK! ๐งช See https://t.co/qiPX93pOmV for more info: https://t.co/jul9fxS07u
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Very proud to share our latest collaborative paper with @BakerGroupUCL where we disclose the chemo- and regio-selective differential modification of cysteines on a native antibody; a first-in-class strategy! Led by the fantastic @yapyongyi! @UCLChemistry
https://t.co/ssC308zyk1
pubs.rsc.org
Protein modification has garnered increasing interest over the past few decades and has become an important tool in many aspects of chemical biology. In recent years, much effort has focused on...
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๐ Happy International Women's Rights Day! ๐ Today, as we celebrate the incredible achievements of women worldwide, let's also reflect on some important numbers with the different TACT members. #IWD2024 #WomenInSTEM
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The Nitrile Bis-Thiol Bioconjugation Reaction | Journal of the American Chemical Society @vijaychudasama_ @UCLChemistry #Thiol #Nitrile #Bioconjugation
pubs.acs.org
Electron-poor aryl nitriles are promising reagents for bioconjugation due to their high electrophilicity and selectivity for reaction with thiols, albeit generally in a reversible manner. A transient...
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It's @LorenzoTurelli_ viva! ๐ฎ๐น Because it's confidential, we had to use our mad Photoshop skills to hide his fantastic work. Can you identify which parts have been edited?
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Congratulations @ChaubetGuilhem and @IKoutsopetras for a great work developing the Ugi reaction for site-selective protein modification! ๐ A great TACT collaboration too involving the ESRs @Maraniach from LSMBO and @yagmurersy from TUM! @MSCActions
"๐ป๐๐ ๐ผ๐๐ ๐บ๐๐๐๐๐๐ ๐ฉ๐๐๐" Extremely proud to report our follow-up study on the application of the Ugi reaction to protein conjugation, this time with โจ๐ฌ๐ข๐ญ๐-๐ฌ๐๐ฅ๐๐๐ญ๐ข๐ฏ๐ ๐๐จ๐ง๐๐ข๐ญ๐ข๐จ๐ง๐ฌโจ https://t.co/BR6MEBsv43
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Let us introduce you to the first two Doctors of the TACT project: @Loic_H10 and @Maraniach! Congratulations to both for their hard work and impressive accomplishments, concluded with an outstanding defense. We wish them all the best for the future! @MSCActions #PhinisheD #TACT
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Extremely happy to have this one out! Huge thanks to @baukevon, Floris and @VijayChudasama_ . Thanks and congratulations to you @RochetLea on this. We finally made it. Thank you @EtnTact for this opportunity- almost half the consortium contributed to this work!
I could not have been more happy with the outcome of this work! Congratulations to @IreneShajan @ORC_PhDs @VijayChudasama_ and many others! Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry | Bioconjugate Chemistry
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I could not have been more happy with the outcome of this work! Congratulations to @IreneShajan @ORC_PhDs @VijayChudasama_ and many others! Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry | Bioconjugate Chemistry
pubs.acs.org
Bispecific antibodies as T cell engagers designed to display binding capabilities to both tumor-associated antigens and antigens on T cells are considered promising agents in the fight against...
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Congratulations @RochetLea and team @VijayChudasama_! Very happy for you to see this one out! With bits of @IKoutsopetras in it, too ๐
Huge congratulations to @RochetLea on her work on the use of pyridazinediones for tuneable & reversible covalent cysteine modification, a highly collaborative project with @BakerGroupUCL @dr_mike_porter @DKBucar Molly Stevens & Abil Aliev, plus many more!
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Very happy to finally have this paper out on one of my main PhD work! Huge thanks to everyone who contributed esp Calise Bahou @jono_wojfor for their precious help in developing this study on tuneable pyridazinedione for cysteine modification! Very grateful to @VijayChudasama_ -
Huge congratulations to @RochetLea on her work on the use of pyridazinediones for tuneable & reversible covalent cysteine modification, a highly collaborative project with @BakerGroupUCL @dr_mike_porter @DKBucar Molly Stevens & Abil Aliev, plus many more!
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Congratulations to our ESR @RochetLea and @VijayChudasama_ โs group for this excellent work on the use of pyridazinediones for tuneable & reversible covalent cysteine modification. ๐ก๏ธ ๐ #TACT #Mariecurie #Horizon2020 #UCL
https://t.co/LfZwtIalz5
pubs.rsc.org
Reversible cysteine modification has been found to be a useful tool for a plethora of applications such as selective enzymatic inhibition, activity-based protein profiling and/or cargo release from a...
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"๐ป๐๐๐๐ฆ, ๐ผ ๐โ๐๐ข๐๐ ๐กโ๐ ๐ด๐ข๐ก๐๐๐๐ก๐๐ ๐๐ฆ๐๐กโ๐๐ ๐๐ ๐๐ ๐๐ก๐๐๐โ๐๐๐๐๐ก๐๐๐๐๐๐๐ฆ ๐ถ๐๐๐๐ข๐๐๐ก๐๐ ๐ด๐๐ก๐๐๐๐๐๐๐ !" Glad to report another work from our former PhD @VLehot in collaboration with the group of Tomรกลก Etrych at @IMC_Prague!
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Every time a speaker is introduced as "did PhD in the lab of X, then post-doc in the lab of Y", it conveys that what matters is to land in some big shot lab. What if instead we introduced; "during PhD he/she discovered X, then during post-doc contributed significantly to Y..."?
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What a nice way to start the week-end! Very thankful to the @LcsoLab ๐จ๐ญ for another fruitful collaboration, spearheaded on our ๐ซ๐ท side by Ilias ๐ฌ๐ท and Rania ๐ฒ๐ฆ from @LSMBO_MassSpec! Truly international work, with the help of @MSCActions, who funded pur @EtnTact ๐ค
EBZ adds a new dimension to biomolecule functionalization with hypervalent iodine, an amazing collaboration between Abhaya @MishraAbhayaK and Ilias @IKoutsopetras at the Chaubet group! @ChaubetGuilhem @BFC_UMR7199 just accepted @ChemEurJ @ERC_Research
https://t.co/Kc27ytlbni
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Check out this new paper resulting from the collaboration between our ESRs @IKoutsopetras (@BFC_UMR7199), @Maraniach (@LSMBO_MassSpec) and @LcsoLab - a new tool for biomolecule functionalization! Congratulations on everyone involved! ๐๐
EBZ adds a new dimension to biomolecule functionalization with hypervalent iodine, an amazing collaboration between Abhaya @MishraAbhayaK and Ilias @IKoutsopetras at the Chaubet group! @ChaubetGuilhem @BFC_UMR7199 just accepted @ChemEurJ @ERC_Research
https://t.co/Kc27ytlbni
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