Esashi Lab also @esashilab.bsky.social
@EsashiLab
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Fumiko Esashi Lab at @Dunn_School, @UniofOxford. Curious about DNA repair, replication and chromosome segregation, the things that make us who we are.
Oxford
Joined January 2020
Ever wonder what’s happening at centromeres in resting cells? Our latest study, led by @xssaayman and in collab with @nussenza, demonstrates striking enrichment of DNA breaks at centromeres in quiescent human cells. Excited to share this work @MolecularCell now!
Online Now: Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence
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Thank Dr. Wan for an exciting talk. This week, Dr. Fumiko Esashi @EsashiLab will discuss centromere instability. Sign up and check out the 2nd half of the year schedule at https://t.co/XaGM9Lt62q
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Huge thanks to everyone involved and the support from the community. We will be moving to another place 🦋- follow us there (@esashilab.bsky.social) if you are curious about what is going on in the Esashi lab!
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This study, conceived 8 years ago, was made possible by a global collab across the UK, USA, Japan and Turkey. The team efforts of Emily and Lucia, relayed by Brian, Jacob, Emoke and Ramazan @rguendogdu, and invaluable assistance from many others, brought this research to life.
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Note that the phenotype varies between cell lines (HCT116 vs RPE1), but in the big picture, we propose that homologous recombination and mismatch repair factors engage in a ‘tug of war’ at centromeres to maintain their functional resilience.
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We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. https://t.co/t6m0rEmZxj
cell.com
Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous cells through distinct mechanisms, partly counteracting the mismatch repair factor MLH1. In cancer cells,...
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We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: https://t.co/ysMXHk7ApK
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This is our contribution to the Special Issue 'Cutting Edge Perspectives in Genome Maintenance XI' @repair_dna, edited by Penny Jeggo. We thank Penny for this great opportunity!
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We find interesting DNA repair mechanisms that are regulated differently in quiescent cells. Excellent work by two talented PhD students, Brian and Jacob, who have contributed equally. There is definitely a lot more to learn and we welcome any feedback you may have!
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Quiescence differs from other non-dividing states, i.e. post-mitotic terminal differentiation and senescence, being able to return to the cell cycle when stimulated. How do they maintain genomic integrity?
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Great pleasure to share our unusual review article, discussing DNA repair in quiescent cells, out now online https://t.co/bQGbBiKEDy
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Programme: June 4, Cell Cycle Club meeting! PROGRAMME (digital & in-person) 4 talks: Barr, @PinesLab, @lab_baum, & Novak labs 1 Keynote: @EsashiLab IN-PERSON @TheCrick Tea/coffee & poster session Networking & drinks REGISTER (FREE) @abcam
https://t.co/nRQhljFVpJ
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Thrilled to be part of the project - big congrats to Dani & everyone involved!
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#1 Happy to share our work “Specialized replication mechanisms maintain genome stability at human centromeres” @MolecularCell from A. Scelfo, A. Angrisani and T. Wilhelm @institut_curie @CNRS where we provide the causes of centromere fragility. https://t.co/2nxkj1mFGm
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Happy to share our review article, discussing DNA strand breaks at centromeres🧬Are they all toxic? We explore their origins and impact across cell cycle stages and quiescence - open access⬇️ https://t.co/Z4lFD4uGqr
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🔬Excited to share the much-requested step-by-step exo-FISH protocol, now in @STARProtocols! Led by @xssaayman, meticulously tested by Emily & Brian, and enriched through peer reviews. 📝 DNA breaks at repetitive regions🧬 Let's advance together! 🚀🚀 https://t.co/fiChSyXsDj
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Our latest📰! Out today in @MolecularCell We used single-molecule imaging to directly observe human BRCA2 tumour suppressor in action! Spearheaded by @BelanOndrej & @LukeGreenhough. A thread. (1/10) https://t.co/hfn2uWSoOw
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🎓🎉 Huge congratulations to Emily on successfully defending her DPhil thesis! 🙌🥳Special thanks to the brilliant examiners, Peter Thorpe (@Thorpelab) and Chris Norbury (@NorbsOx), for their insightful discussion. Well done, Emily! 🍾🥂
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After many happy years at the University of Oxford, I am delighted to announce that I will shortly be joining the Genome Damage and Stability Centre, University of Sussex. Thank you @oxfordoncology, Hello @gdsc_sussex
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Looking for #postdocposition? Excited about R-loop biology? Still, 10 days to apply for an MRC-funded position in the Gromak Lab! @Dunn_School ⬇️⬇️
And another postdoc opportunity! Join the Gromak lab and help investigate the role of R-loop biology in health and disease. More info about the group here: https://t.co/SHWOvW3iQA Deadline: 12th May Advert: https://t.co/Ipo5a49j3H Please share!
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