Nichlas M Engels
@EngelsNichlas
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Harris Lab, University of Arizona Ph.D student. B.S in Biology from UNC Chapel Hill Previously a research tech in Giudice Lab-UNC #S04 #GoHeels
Tucson, Arizona
Joined November 2019
It was very nice to welcome our muscle users @HesselAnthony @mikuehn8 @vivekpjani back after two years for @advancedphoton upgrade. BioCAT remains the state-of-art facility for muscle X-ray diffraction. Proposal for next run due in two days!
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As #BPS2025 nears, we wanted to highlight a recent publication in biophysics! 🔬 @HesselAnthony et al. investigated the role of MyBP-C in muscle 💪contraction and regulation with small-angle X-ray diffraction and #AuroraScientific 1600A system. https://t.co/tP8s3bRw0y
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Huge beamrun over at LiX beamline, NSLS II @BrookhavenLab. Last 96 hours with veterterans @EngelsNichlas / Rachel Sadler, Christine Delligatti @cdelligatti13, and the brilliant @KhoiD_Nguyen.
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@EngelsNichlas puts in the big effort at @advancedphoton @argonne and NSLSII @BrookhavenLab during monster data collection runs. Head down / stay positive. He w/ @sp_harris1 lab are uncovering the roll of MyBPC to the regulation of force production. Loads more projects incoming!
@EngelsNichlas, We are excited to see your presentation! You are making #MyBPC famous! @UArizonaCMM @UAZHeart @UAZHealth @UAZBIO5
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@EngelsNichlas, We are excited to see your presentation! You are making #MyBPC famous! @UArizonaCMM @UAZHeart @UAZHealth @UAZBIO5
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Day 12, 230am. It is Finished! We are out of samples! The monster beamline run is over! What a ride! So many things accomplished over 2 continents and beamlines. Mouse hearts, human hearts, various skeletal muscles, cardiac strips, zebra fish, MARP proteins...214 hours of work.
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Day 10/11. Heavy lifting back at NSLSII at BNL. Some hiccups on the way: RIP special ABs at Newark customs. But lots of success on several other projects! @KhoiD_Nguyen, @EngelsNichlas, Rachel Sadler, and Brad Palmer Crew working at max capacity! Final 40 hour push starts now.
Day 7/8 (what are 6 time zones among friends?). The @mikuehn8 crew are rolling hard at P03 beamline PetraIII, @desynews. Really interesting data from these sick mutant mouse muscles. Now on a plane back to the LiX beamline NSLS-II @BrookhavenLab for 4 more days!
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And we are three days in! So many pappilary muscles. Progress ok! Now a quick shower, pack a bag, prep a few more samples, and then straight to the plane for the Hamburg run at @desy! See you soon @mikuehn8!
T-0.5 days until our Xray beamrun. Build day! Long day of vpreparing. Tomorrow is showtime!
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T-0.5 days until our Xray beamrun. Build day! Long day of vpreparing. Tomorrow is showtime!
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Assistant Professor Weikang Ma pushes the boundaries of science, searching for ways to protect the heart against inherited cardiac diseases. Having received a $2 million grant from @NIH, Ma’s research is on the path to a new frontier. Discover Ma's impact: https://t.co/KHYCZUuA0e
iit.edu
When it comes to keeping hearts pumping, Illinois Institute of Technology Research Assistant Professor
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Researchers led by Dr. @HesselAnthony reported that fast myosin binding protein C knockout in #SkeletalMuscle 💪 alters length-dependent activation and myofilament structure. 📍 @CommsBio | https://t.co/SWLiO1PYfG
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This is how great science is made, by 75% Chinese rockets fuel @HesselAnthony @mikuehn8 @EngelsNichlas @vivekpjani
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This bike lock is/was available for sale on campus via Columbia's Public Safety department under their "Crime Prevention Discount Bike, Locker and Laptop Lock Program". See their flier with a discount here: https://t.co/cXudPIG70k
Deputy Commissioner Tarik Sheppard shows the chains used to secure Hamilton Hall at Columbia University. "This is not what students bring to school. This is what professionals bring to campuses and universities."
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Great visit with @HesselAnthony! Such a great scientist and colleague!
Just wrapping up an amazing few days with the @sp_harris1 lab! A little celebration of our new Nat Comm paper but already scheming for the bombshell follow-up paper being prepared by @EngelsNichlas. See you all at the myofilament meeting!
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@musclecellnews @EngelsNichlas @sp_harris1 Also @mikuehn8 and Dr. Weikang Ma at the BioCAT beamline, @advancedphoton @argonne
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Scientists including Drs. @HesselAnthony, @EngelsNichlas, & @sp_harris1 reported that myosin-binding protein C regulates the #sarcomere lattice and stabilizes the OFF states of #myosin heads. 👉 https://t.co/4Et1BuQVvm
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Just wrapping up an amazing few days with the @sp_harris1 lab! A little celebration of our new Nat Comm paper but already scheming for the bombshell follow-up paper being prepared by @EngelsNichlas. See you all at the myofilament meeting!
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So excited to share this work is now published in @NatureComms. It was great to work with @HesselAnthony throughout the process, and I look forward to sharing MyBP-C cleavage structural changes in active skeletal muscle in the next one!
Really excited to announce our work using controlled MyBP-C cleavage in skeletal muscle is now published open access in @NatureComms! @sp_harris1 and I agreed to this collab in September 2022 and now complete! Ask any Qs in the comments! 👨🔬👩🔬🔬💪 https://t.co/5TcwHF3fP2
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🫀🧑🔬💪Really excited to share that my first *cardiac* research project was accepted to Circulation Research! We study relaxed permeabilized papillary muscles before and after rapid 50% I-band titin cleavage with TEV protease. Below are the major findings.
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Hey @ArizonaMBB, Now we are and our runway is clear for takeoff! 🛫⛅️
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