#OPENACCESS: A higher ATP concentration turns thick myosin filaments into an ON state, leading to altered cross-bridge kinetics. These X-ray data correlate low ATP levels to the inactivated myosin state observed in certain heart diseases.

Our symposium is just around the corner—don’t forget to register to receive the Zoom link for the event. We look forward to seeing you there. https://t.co/cjcmuyaCT6

Excited to share BioCAT P30 grant received an outstanding overall impact score of 16! Grateful that the Fiber Core, which I lead, earned a perfect score of 10—a testament to the incredible work of our team and user community. We look forward to serve the field in the years ahead.

The “sound” of the heart beats!

The PI of BioCAT, Thomas Irving, will give a talk today at 3:15-4:30pm CST titled “30 years of Muscle Diffraction at BioCAT - What have we learned about muscle contraction?” Welcome to join https://t.co/iGtVT2fvym

It was very nice to welcome our muscle users @HesselAnthony @mikuehn8 @vivekpjani back after two years for @advancedphoton upgrade. BioCAT remains the state-of-art facility for muscle X-ray diffraction. Proposal for next run due in two days!

A definition of a long haul. Very glad to see this one came through after years of work.

Very productive run at @CHESS_user with @vivekpjani and Marcus. We collect patterns from human heart tissue (HFpEF, HFrEF, HCM, SVD) probably for the first time ever there, and more patterns from animal hearts. Looking forward to come back soon!!!

Very nice to see this project in the press!

Congrats @vivekpjani well deserved

First decoration at the new Fulton Lab

We are glad to share that we got all the beam we expected from the new @advancedphoton into our experimental hutch, ~4 × 10^13 photons/sec at 250um ×250 um unfocused. We expect to welcome users back in the near future after the scientific commissioning.

Kyrah L. Turner (@wsusbs) et al. discovered that the structural and functional effects of myosin regulatory light chain #phosphorylation are amplified by increases in sarcomere length and [Ca2+] 💡 📜Read the #Research here: https://t.co/2wKxbdVMdN

Thick filament structural changes in the presence of calcium. From Saffie Mohran, Weikang Ma & colleagues @MuscleX_Lab @illinoistech showing that calcium has a direct effect on thick filament activation in porcine myocardium: https://t.co/1ZxVzf5CPk #Myofilaments #CardiacMuscle

These advancements will unlock exciting new possibilities for us to better serve the scientific community. We are currently undergoing technical commissioning, followed by scientific commissioning, before opening to general users. Stay tuned for further updates!

After a 17-month hiatus, we are excited to announce that BioCAT has received its first X-ray light from the upgraded APS. We anticipate a 50-fold increase in flux density from the APS upgrade, with an additional 100-fold increase following upcoming beamline optics enhancements.

Calcium has a direct effect on thick filament activation in porcine myocardium, say Saffie Mohran, Weikang Ma @MuscleX_Lab @illinoistech and colleagues @FMoussaviHarami @LabRegnier @UW_CTMR @UWBioE: https://t.co/fy8wkcenm4 #CellMotility #Myofilaments #CardiacMuscle

Job opportunity: @MuscleX_Lab's Weikang Ma and myself over @AMBiotechTeam are looking to create an "industry postdoc" position. Part time work for IIT/BioCAT and part time work for AMB. All publishable research science with potential of independent research. DM us if interested!

Here is a great opportunity for a PhD in Muscle Biophysics/Physiology in London @KclPhysiology @KCLBMBioscience

Very nice to see the work between @MuscleX_Lab at @illinoistech and @LabRegnier @FMoussaviHarami at @UW finally published in @JGenPhysiol. It has been a very long and productive collaboration and more papers in the making!!!