DziembowskiLab
@DziembowskiLab
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Laboratory of RNA Biology - ERA Chairs Group at @IIMCB_Poland, headed by @AndrzejDziembo1 #MOSaIC #ERAChairs #DziembowskiLab
Warsaw, Poland
Joined December 2022
Our recent study published in @Nature uncovers #TENT5A-mediated re-adenylation as a crucial factor in stabilizing therapeutic #mRNA and enhancing its immunogenicity in #SARS_CoV_2 #vaccines.
Happy to share with you our new @Nature story about the crucial role of TENT5A-mediated re-adenylation of mRNA COVID-19 vaccines in boosting their efficacy. We also show how important macrophages are in producing the antigen following vaccination. @
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RT @IIMCB_Poland: 📢The 2024 Parnas Award 🏆– the top distinction of the Polish Biochemical Society – goes to the IIMCB team led by Prof. And….
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RT @IIMCB_Poland: Scientists from the IIMCB described a new mechanism that improves the efficiency of mRNA-based therapies. The research fi….
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RT @pakraw: 🎉 Incredibly proud to share my first-author paper in @Nature! Heartfelt thanks to my mentor @AndrzejDziembo1 and the brilliant….
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RT @IIMCB_Poland: During the International Advisory Board meeting, we once again had the opportunity to celebrate a historic milestone – th….
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@nanopore #Ninetails is freely available for researchers worldwide (, opening new avenues to explore #RNA biology.
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@nanopore #Ninetails outperforms existing approaches as it avoids amplification artifacts and provides single-read (@nanopore) resolution of #polyA tail composition. It classifies non-adenosine residues with >93% accuracy and ~98% specificity.
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@nanopore For the #Moderna #mRNA1273 vaccine analyzed in time-course post-administration in #macrophages, #TENT5A-extended tails are rich in non-adenosines. More details in the paper which comes out in April. #StayTuned.
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@nanopore Notably, mitochondrial #mRNAs and #TENT5 polymerase substrates (the focus of our lab) are enriched in non-adenosines. This highlights that different #polyA #polymerases exhibit varying fidelities.
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The latest achievement from the lab, Ninetails, published at @NatureComms. This is the first fully #bioinformatics paper from the lab. Huge congrats to @nemithesaura. #RNA #nanopore #polyA #nonadenosines.
I am happy to share our most recent results published in Nature Communications. Ninetails - a pipeline for detection of non-adenosines in poly(A) tails of Oxford Nanopore Direct RNA Sequencing reads. Many thanks to LBR lab members for this work.
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RT @IIMCB_Poland: Our researchers secured MAESTRO 16 & SONATA BIS 14 grants from @NCN_PL ! 🎉.🔬 TENT5A & Hormonal Regulation – Prof. Dziembo….
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RT @IIMCB_Poland: 📢 Prof. @AndrzejDziembo1 elected to the @RNASociety Board of Directors! 🎉 This global organization unites over 2,500 memb….
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RT @A_Chacinska: Jutro 6.10: .1. Ogłoszenie Nagrody Nobla w Medycynie i Fizjologii .2. Najlepsi badacze z grantami ERC reprezentujący zaint….
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RT @NCN_PL: "Stan nauki w Polsce jest kwestią racji stanu i to od niego zależy przyszłość naszego państwa, nie możemy pozwolić, aby nauka i….
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RT @IIMCB_Poland: @AndrzejDziembo1 & his group plan to investigate ways to increase the stability of mRNA, allowing for their deeper integr….
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RT @drfigiel: Following up on our paper about AbiK and Abi-P2, we now present an in-depth characterization of the third Abi polymerase, Abi….
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RT @IIMCB_Poland: Join us and contribute to the long-term development of all core facilities at the IIMCB. As a Core Facility Technology Ma….
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RT @IIMCB_Poland: @DziembowskiLab is inviting applications for a Postdoctoral Researcher and a Research Assistant. Apply now: https://t.co/….
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