Sophie Dumont
@DumontLab
Followers
3K
Following
2K
Media
30
Statuses
279
Mechanics of cell division @UCSF
San Francisco, CA
Joined May 2015
Excited to share our work out in @CurrentBiology today! We find that NuMA acts as a spindle "glue" - independent of its partner dynein. Congrats to student Nathan Cho who led the work, and thanks to Merve, Aryan and @Yildiz_Lab for in vitro help.
cell.com
Cho et al. show that NuMA plays a dynein-independent role during mitosis, passively reinforcing spindle poles. NuMA’s length and self-interactions are important for its ability to protect spindle...
1
9
37
Excited to share NuMA preprint #2/2! We report structural and functional insights into how NuMA activates and regulates dynein at cell division. Congrats to Merve Aslan @Yildiz_Lab, @AmicoEnnio @Carter_Lab and Nathan Cho from our lab. And others inc. Maddie Blaauw from our lab.
0
4
9
Excited to share NuMA preprint #1/2! We find that NuMA mechanically reinforces the spindle independently of its partner dynein. Congrats to student Nathan Cho who led the work, with Merve Aslan and @Yildiz_Lab.
biorxiv.org
Both motor and non-motor proteins organize microtubules to build the spindle and maintain it against opposing forces. NuMA, a long microtubule binding protein, is essential to spindle structure and...
0
4
19
@alexandraflong Alex was a postdoc with Tim @StearnsLab & Jessica Feldman
0
1
3
Congrats to Alexandra Long @alexandraflong, the second student from our lab to start their own lab! Her lab is in Univ. Kentucky's Biology Dept, studying the evolutionary cell biology & biophysics of cellular organization. Check it out!
alonglab.org
Long Research Group - Univ. Kentucky
1
2
13
Excited to share our work out in @CurrentBiology ! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux
1
10
27
Nominate a colleague or yourself for the Motility and Cytoskeleton Early Career Award at the 2025 Biophysical Society Meeting! To do so fill out this form and email Radhika Subramanian and I your CVs by Dec 1 2024:
docs.google.com
We are soliciting nominations for the Biophysical Society's Motility and Cytoskeleton Subgroup Early Career Award which will be awarded at the subgroup session in February 2025. The Early Career...
0
22
30
Christina was a postdoc with Alex Dunn @Dunn_Lab. And wrote a book with Rob Phillips, The Restless Cell: Continuum Theories of Living Matter. Wow ...
0
1
7
Congrats to Christina Hueschen @clhueschen, the first student from our lab to start their own lab! Her lab is in UCSD's Cell & Dev Bio Dept, studying the physical biology of parasites. Can't wait to see what science they do. Check it out!
5
6
82
With this work we are sad to say goodbye to postdoc Miquel @RosasSalvans who is returning to Barcelona. We will miss Miquel's intellect, generous spirit, and all the fun times doing science together. Best of luck!
0
1
8
Excited to share a preprint! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das.
1
7
19
Nominate a colleague or yourself to speak at the Motility & Cytoskeleton Subgroup at the 2025 Biophysical Society Meeting! Radhika Subramanian and I are organizing the subgroup and looking for nominations by July 8th: https://t.co/Ld4JIdspTX.
docs.google.com
We are soliciting nominations for speakers for the Motility and Cytoskeleton Subgroup session at the 2025 Biophysical Society meeting. Nominees should be individuals who have not spoken at the BPS...
1
14
27
Excited to share our work @JCellBiol! We find that torques within and outside the spindle oppose each other to limit spindle twist during anaphase. Congrats to @LilaNeahring who led the work! Thanks to Nathan Cho, @Caleb_J_Rux, @Yildiz_Lab, Upadhyayula and Subramanian Labs.
1
8
47
Excited to share our work @JCellBiol! We find that chromosome size-dependent spindle forces impair mammalian mitotic error correction of long chromosomes. Congrats to graduate student @megan_chong who led this work! With Miquel @RosasSalvans @VannaTran5
https://t.co/mSBj0Rs25G
3
29
100
Excited to share our work out in @PLOSONE with @goga_lab showing that expressing an oncogene protects spindle poles from fracturing in mechanically confined environments. Congrats to first authors @RenaldoSutanto and @LilaNeahring and all authors!
journals.plos.org
The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic...
1
10
45
Congratulations to graduate student @megan_chong from our lab who received a UCSF Dean’s Award for Excellence in Mentoring! Megan is an inspiring mentor to many in our lab and out. And congrats to all other awardees! @UCSFGradDiv
1
6
60
Thanks to Nathan Cho, @Caleb_J_Rux and collaborators @Yildiz_Lab, Upadhyayula and Subramanian Labs!
0
0
2
Excited to share a preprint! We find that torques within and outside the human spindle oppose each other to limit spindle twist during chromosome segregation. Congrats to @LilaNeahring who led the work!
biorxiv.org
At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale spindle. Many mitotic motors step helically around microtubules in vitro, and most are predicted to twist...
1
9
50
Our lab is exicted to be at @ASCBiology
#cellbio2023 in Boston. Come check out what we've been up to! @c3STC
0
5
43