Shyam
@Dr_Shyam_S
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Pediatric Oncologist / Thinker / Husband / coffee ☕ lover / 🍻 Addict / Lark person / தமிழன்.
Mumbai, India
Joined April 2022
🚨 New study alert! @Dr_Shyam_S @DrGauravNarula @DHCA11 Using fixed low-dose nivolumab (40mg D1 & D15; ~1.2mg/kg) + bendamustine, we achieved 88% CR after 2 cycles in high-risk pediatric rrHL. Full article: https://t.co/bU5tyHU8Zf
#PedsOnc #HodgkinLymphoma #Immunotherapy
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Highlights: 1) Cost of therapy: $4454 per newly diagnosed AMLs (~100 times less compared to west) 2) Cost per DALY averted: 24% of India's GDP per capita rendering Rx as "cost-effective" 3) NGOs and government schemes essential for improving access to affordable healthcare
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Is treating childhood AML cost effective in India ? Read our latest publication from @TMC_Varanasi
https://t.co/uRHfqyHaz1
@kidzcancerdoc @WorldSIOP @pho_india @INPHOG @ShaliniJatia @cspramesh
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"Due to vip movement out of Mumbai there is air traffic congestion and we are awaiting for a confirmation as to when we can land". We eventually ended up flying around in Mumbai's turbulent weather for an hour before landing. Unbelievable!!! @nvpatkar
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Yesterday, we took a flight from Nagpur to Mumbai which was already delayed due to bad weather conditions. The aircraft did not land for an hour (close to midnight) in Mumbai. To everyone's shock it was not due to the weather and the announcement made from the cockpit was....
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Our Findings on risk factors for MTX neurotoxicity in Pediatric Leukemia/Lymphoma published @BrJHaem in a large cohort of 622 patients https://t.co/I1FGeBu1Bx older children with Cns leukemia and developing tumor lysis may be at higher risk, led by @ThirumalaR85052 @drajaysankar
onlinelibrary.wiley.com
Methotrexate (MTX), although an indispensable part of contemporary treatment protocols for childhood acute lymphoblastic leukaemia (ALL)/lymphomas (LBL) in improving outcomes, can lead to serious...
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India’s first CAR-T cell therapy is developed through collaboration between the Indian Institute of Technology, Bombay and Tata Memorial Hospital in association with industry partner ImmunoACT. So, we have two of India’s pioneering research institutes in their respective fields,
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📢Excited to share our commentary on the influence of 𝒊𝒎𝒎𝒐𝒓𝒕𝒂𝒍 𝒕𝒊𝒎𝒆 𝒃𝒊𝒂𝒔 on osteonecrosis and survival outcomes in childhood ALL! 📚 Explore our insights from the recent analysis of the COG ALL0232 trial, now featured in @LeukemiaJnl. https://t.co/KA7t7yNcrb
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Another PBC must-read: KIT exon 17 mutations are predictive of inferior outcome in pediatric acute myeloid leukemia with RUNX1::RUNX1T1 #PedsHemeOnc #PHODocs #PHOAPPs
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📢Exon 17 KIT mutation associated with⬆️relapse risk &⬇️overall survival in childhood RUNX1::RUNX1T1 AML. 🌟A high KIT VAF (>33%) correlated with poor survival. ❓Alternative strategy. https://t.co/WOoJLgCSdk
@DHCA11 @DrGauravNarula @nvpatkar @Gaurav_C42 @TataMemorial
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Precision medicine for children with cancer: 📚 Essential Reading: Dive into Ian F Tannock's Latest Comment! 🔍 #MustRead @TheLancet @csoncol @ASCO @myESMO @OncoAlert
https://t.co/cnq3yamgXW
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Glad to share our work on Methotrexate induced neurotoxicity in pediatric ALL https://t.co/dqBDNLUytA Long story short, safe re-challenge is possible! @NirmalyaRoyMoulik @DrSwamiPeds @Dr_Shyam_S @DrGauravNarula @ChetanDhamne @DrKalasekhar @vasudev16101985 @BadiraP
tandfonline.com
Methotrexate-induced neurotoxicity is a well-defined side-effect of high-dose and intrathecal methotrexate with characteristic clinico-radiological findings and transient nature. Our experience in ...
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Tailored strategies and targetted immunotherapies - need of the hour in LMICs for managing Pediatric relapse B ALL. Happy to be part of this study from @TataMemorial @DrGauravNarula @Dr_Shyam_S @venkymd @Subramaniamrdr @deepakbansaldr1 @dhariwal_nidhi
https://t.co/eJ4kCllmCI
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Granulocyte may be the answer for treating MDRO sepsis in children with cancer. Glad to be part of this study from @TataMemorial , Mumbai. @DrGauravNarula
@DHCA11 @BadiraP @DrKalasekhar
@venkymd @dhariwal_nidhi
@Dr_Shyam_S
https://t.co/eX4SWlmHPy
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Check out our latest publication in @AjHematology: https://t.co/0nMx8oyAVR We assessed MRD by high-sensitivity NGS-based assay for IG/TCR vs. standard of care PCR for BCR::ABL1 in patients with newly diagnosed Ph+ ALL. #ALLsm
@NicholasShortMD @DrHKantarjian @MDAndersonNews
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In this study, the addition of blinatumomab to standard chemotherapy improved disease-free and overall survival among infants with KMT2A-rearranged ALL, with minimal additional toxic effects.
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Hepatoblastoma- treatment outcomes and prognostic factors @TataMemorial Congrats for a nice paper in this month’s PBC. #ShyamS @BadiraP #SajidQureshi #NehalKhanna #SiddharthLaskar #GirishChinnaswamy #MayaPrasad and team
onlinelibrary.wiley.com
Background Not all the significant progress made in the management of children with hepatoblastoma (HB) has translated into improved outcomes in limited-resource settings. There are limited data on...
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Two days of interactive academic sessions at Pediatric solid tumour workshop @TataMemorial Mumbai. More than 200 attendees and 30 faculty ( national and international) @pho_india @INPHOG @vasudev16101985 @DrKalasekhar
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