Dr Lucy MacDonald
@DrLucyMac
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PostDoc at @DrMariola lab @UofGSii 🏴 Researching synovial tissue macrophages & DC in RA with single cell & spatial transcriptomics 🧬🔬
University of Glasgow, UK
Joined October 2013
Yesterday I had my PhD graduation. Not ashamed to say I’m super proud of everything I’ve achieved this year - having a baby only 3 weeks after submitting my thesis and a week after my viva. But the highlight of my day was finding Alfie’s first tooth 🥹 Officially Dr MacDonald!
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RT @HaoYin20: Crescendo, a Harmony extension for #SpatialTranscriptomics #BatchCorrection at the level of individual gene counts. Generaliz….
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RT @GlasgowCC: Calving season is well and truly underway at Pollok Country Park 🐄. Check out these udderly cute baby coos running around th….
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RT @chiara_pirillo: Being a scientist as a woman means constantly balancing curiosity with courage, forging new paths in a world that wasn’….
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RT @UofGSii: 🆕 | Research led by @UofGSii scientists, including senior author @DrMariola Kurowska-Stolarska, as part of @Racegbn has pinpoi….
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RT @NatRevRheumatol: #ResearchHighlight ✨| Synovial dendritic cell subsets in RA. Read the original article here: .
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RT @mfgrp: Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response….
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Wow!.
Stanford Medicine scientists have developed an experimental topical vaccine, using a bacterium that naturally lives on human skin, that could pave the way for a needle-free protection against numerous toxins and pathogens.
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Diverse DC and T cell populations are depicted as colorful tiles forming patterns in the ST (mosaic floor) atop the bloodstream (central heating system, hypocaustum) from which DCs infiltrate the ST, determining the three conditions: health, disease, and remission.
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The discovery process is illustrated as a team of archaeologists uncovering the intricate patterns of a mosaic floor in an ancient Roman house (domus romana).
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We identify functional features of distinct ST-DCs that provide insight into the roles of these cells in immune tolerance and disease.
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MacDonald et al. investigate the role of synovial tissue (ST) myeloid dendritic cells (DCs) in health, active, and remission stages of rheumatoid arthritis (RA).
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RT @LabWaggoner: Synovial tissue myeloid DC subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthri….
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RT @UofGMVLS: New @UofGlasgow research has pinpointed key cells that could be targeted to prevent painful rheumatoid arthritis flare-ups, o….
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RT @ImmunityCP: Online now: Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in heal….
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This work was a collaboration between our lab @DrMariola at @Racegbn @UofGSii and @SteAlivernini lab @SYNGemBU 🏴🇮🇹 with lots of support from @ilyakorsunsky lab in 🇺🇸.
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