The more exercise in mid- and late-life, the less Alzheimer's and all-cause dementia, adjusted for all known risk factors https://t.co/BJlSqpEIIj

2/ Observed PEP rate: 5 vs 9 events; 0.31 vs 0.6/100 PY; RR 0.56, 0.19-1.65 Sample size required at observed rates: >11084 What can one learn from a trial with total of 14 PEP events and 12 stroke/SE events over 3 years of follow-up?

I agree with @drjohnm’s perspective on LAAC. As an additional piece of orthogonal evidence: Our group, as well as multiple others, have shown that AI-ECG can predict AF from sinus ECGs. When you apply these models or try to directly train an AI-ECG model to predict stroke, they

Presented at #AHA25: In patients with atrial fibrillation after successful ablation, rivaroxaban therapy did not lead to a significantly lower incidence of a composite of stroke, systemic embolism, or new covert embolic stroke than aspirin therapy. Full OCEAN trial results:

Ok you all, here is my take of the CLOSURE AF trial. On @theheartorg https://t.co/WppsVncNfi Teaser: this may herald cardiology's biggest medical reversal. Nonindustry funded, non-biased trial. LAAC clearly inferior to best medical therapy (usually DOAC, but 10% no AC.) #AHA25

LAAC vs best medical care Thrombotic events - higher Bleeding events -- higher (counting procedure; also see AVERROES) CV death -- higher (please don't dare tell me that it was noise because if you do, let's relook at PROTECT and PREVAIL LAAC done in experienced labs

look forward to seeing the data

thank you @Theodorou_Aik

SCIENCE: In a 25-year study of over 25,000 women in the United States, adherence to the Mediterranean diet was associated with a 23% reduced risk of mortality. (Source: JAMA Network)

finally a dedicated RCT looking at stroke as primary endpoint. let's be cautiously optimistic until longer outcome data is available

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits. https://t.co/Se4XnZyuNE

𝗣𝗿𝗲𝗽𝗮𝗿𝗶𝗻𝗴 𝗧𝗿𝗮𝗶𝗻𝗲𝗲𝘀 𝗳𝗼𝗿 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗨𝗻𝗰𝗲𝗿𝘁𝗮𝗶𝗻𝘁𝘆 Uncertainty is ubiquitous in medical practice yet is often viewed as a regrettable phenomenon to be tolerated or eradicated. To prepare trainees for practice, teachers need to reframe uncertainty

Terry Rozier guilty as hell 😭😭😭

This!! No evidence that adding aspirin to AC in patients with both afib and athero is better than AC alone, And inc risk of hemorrhage.

Early Tirofiban Infusion after IV Thrombolysis for Stroke In this trial of >800 AIS pts (mostly small vessel, all not EVT eligible), infusion of this GP 2B/3A inhibitor anti platelet agent after IVT significantly improve the likelihood of good outcome (mRS 0-1) — with a small

Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity: @NEJM 🥸 Oral Ozempic will be followed by an oral Zepbound 😱 OASIS-4 results 👇👇👇

Opinion: As a heart surgeon, I chased excellence. It cost me my body and my mind /via @globeandmail

5 breakthroughs in medicine this week 1. Highly effective obesity pills are nearly here Eli Lilly’s oral Orforglipron and Novo Nordisk’s oral semaglutide both achieved ~10% weight loss in phase 3 trials Here’s how they compare to the rest of the pipeline:

4. Apple watch FDA-cleared to detect high blood pressure Hypertension is the 'silent killer', because it usually causes no symptoms — but it's the leading risk factor for stroke This could help increase diagnosis of high blood pressure, and make it a little less ‘silent’

The 2024 revisions of the McDonald criteria for diagnosis of #MultipleSclerosis are out ▶️