Darren Poole
@DPSynthChemist
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Team leader @GSK high-throughput chemistry | New methodologies and enabling technologies for drug discovery | DPhil @DonohoeGroup | F1 Obsessive | Views my own!
Joined May 2021
New in Organic Letters! ⚡ eEtherification: A mild, versatile electrochemical method to synthesise sterically hindered ethers from common alcohols. 🎄 By @KLChemistry & team @UniofGreenwich @GSK #OrgLett
pubs.acs.org
Traditional etherification methods, although staples in synthetic chemistry, often fall short in the efficient construction of sterically hindered dialkyl ethers, especially under mild and practical...
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🎄 Christmas surprise by @CK_echem, @DPSynthChemist & team @UniofGreenwich @FESGreenwich @GSK ⚡ eEtherification ⚡: Rapid, efficient, and versatile assembly of sterically hindered ethers from readily available alcohols. #RealTimeChem #OrganoeChem
https://t.co/F2iu6bnqBK
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Check out @CK_echem and his cool new eEtherification in @JOC_OL! Another cool transformation enabled by electrochemistry in our @GSK collaboration with @KLchemistry @UniofGreenwich ⚡️
Looking forward to having an electrifying Christmas?🎄Discover our new⚡️eEtherification⚡️out in @JOC_OL ! https://t.co/pJhaqeeELv I am very happy to share this amazing work with @KLchemistry , @DPSynthChemist , @S_Kaltenberger , @daraydan1 and @MorlacciValerio !
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Congratulations to @HarryWilders and the team for getting this exciting ‘Direct-to-Biology’ work out there! We generate cysteine-targeting chloroactemide reactive fragments and screen them without purification to optimise inhibitors of SARS MPro. https://t.co/p9HAkxKHiJ
onlinelibrary.wiley.com
Direct-to-biology workflows promise to accelerate hit optimisation for drug discovery. Here, we describe a direct-to-biology method for the efficient synthesis and screening of cysteine-reactive...
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Redox-Tunable #RingExpansion Enabled By A Single-Component Electrophilic Nitrogen Atom Synthon (Mark D. Levin and co-workers) @LevinChem @group_levin @pqkellychem @UChiChemistry #openaccess
onlinelibrary.wiley.com
A novel hypervalent iodine reagent that allows electrophilic nitrenoid transfer is reported. α-amination of indanone β-ketoesters allows divergent ring expansions to either isoquinolones (thermal...
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"Farewell, ☠️KCN!" Meet #eCyanation: the safer, scalable way to perform nucleophilic & electrophilic cyanations! Incredible work by @MorlacciValerio &⚡ElectraTeam⚡at @UniofGreenwich! Transforming #GreenChemistry!#RealTimeChem #OpenAccess @DualFlowProject
https://t.co/UvS3Lve7pC
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We are pleased to open our recruitment for our collaborative @GSK/@StrathChem PhD Studentships starting Oct 2025 in the areas of Synthetic and Medicinal Chemistry. Students will be based at GSK, Stevenage. Full details below and at: https://t.co/MjROTV2YBi Deadline: 06/01/2025.
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📣 Session 12 – Dr. Pilar MANZANO-CHINCHON from @GSK is now on the stage for the talk titled “Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma Cruzi Proteasome Inhibitors”. Keep following us! 🔬💡 #EFMCISMC24 #MedChem
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📣Starting Session 3: “Novel methodologies in photo- and electrochemistry” in Room Pantheon chaired by Dr Lisa Candish, with a lecture from Ms Gemma Cook of @GSK on "The Application of Photochemistry to Accelerate the Discovery of Drug Candidates at GSK" #EFMCISMC24 #MedChem
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Steve (not on twitter) et al’s study on Rh(I)-Catalyzed Regio- and Enantioselective Ring Opening of Vinyl Cyclopropanes | Journal of the American Chemical Society
pubs.acs.org
We describe a Rh(I) catalyzed asymmetric ring opening of racemic vinyl cyclopropanes using aryl boronic acids as C-nucleophiles. When ferrocene-based chiral bisphosphines are used as ligands, the...
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I love this work from Asmaul and Tianxiao in the @Stahl_Lab . Sulfoxide synthesis without overoxidation? ✅. Simplest oxidant? ✅. @DPSynthChemist and I think the community will find this useful so check it out!
Asmaul and Tianxiao take us one step closer to eliminating peroxides and other undesirable oxidants in organic chemistry. Thanks to @DPSynthChemist @GSK for med chem contributions!
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Absolutely delighted to see this paper with Asmaul, Tianxiao and Shannon @Stahl_Lab appearing in @J_A_C_S! Thrilled to have been a part of this very enjoyable collaboration to selectively oxidise sulfur to sulfoxides electrochemically ⚡️
Asmaul and Tianxiao take us one step closer to eliminating peroxides and other undesirable oxidants in organic chemistry. Thanks to @DPSynthChemist @GSK for med chem contributions!
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Asmaul and Tianxiao take us one step closer to eliminating peroxides and other undesirable oxidants in organic chemistry. Thanks to @DPSynthChemist @GSK for med chem contributions!
pubs.acs.org
Oxygen-atom transfer reactions are a prominent class of synthetic redox reactions that often use high-energy oxygen-atom donor reagents. Electrochemical methods can bypass these reagents by using...
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Time to say “Goodbye for now” to @CK_echem who’s going to spend the rest of his PhD at @GSK with @DPSynthChemist! #RealTimeChem
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Awesome job, @Anderson_J_M!!
So awesome to see @Anderson_J_M’s PhD work on bridge substituted BCPs highlighted in Synthesis Workshop @MatthewHorwitz1! Well done Joe and the rest of the crew @GSK @StrathChem
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Today on Synthesis Workshop, Joe Anderson (GSK, University of Strathclyde) joins us to share his work on the synthesis of bridge-substituted BCPs! Link: https://t.co/jUEwVEiOlp Key paper: @ChemEurJ 2024, 30, e202304070. https://t.co/BIxFTshiPm
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Excited to see this video released which covers some of the work from my PhD @GSK and @StrathChem. Thank you @MatthewHorwitz1 for the opportunity to present, and to my supervisors/co-authors @DPSynthChemist, @NickMeasom, Prof. John Murphy, and @GemmaCharlotte3 for their support.
Today on Synthesis Workshop, Joe Anderson (GSK, University of Strathclyde) joins us to share his work on the synthesis of bridge-substituted BCPs! Link: https://t.co/jUEwVEiOlp Key paper: @ChemEurJ 2024, 30, e202304070. https://t.co/BIxFTshiPm
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So awesome to see @Anderson_J_M’s PhD work on bridge substituted BCPs highlighted in Synthesis Workshop @MatthewHorwitz1! Well done Joe and the rest of the crew @GSK @StrathChem
Excited to see this video released which covers some of the work from my PhD @GSK and @StrathChem. Thank you @MatthewHorwitz1 for the opportunity to present, and to my supervisors/co-authors @DPSynthChemist, @NickMeasom, Prof. John Murphy, and @GemmaCharlotte3 for their support.
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Check out “Utilization of HTE and ChemBeads Toward the Development of an Aryl Bromide and Benzyl Bromide Photoredox Cross-Electrophile Coupling.” Synthesis of diarylmethanes by @GSKUS (@Marty_Rauch, @ngcercizi, @tessacolameta, @jpatphelan, @AnnRowley_77) https://t.co/pPfybgwlXz
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