Dr Sam Rowe
@SamMRowe
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Investigator in GSK’s Chemical Biology Team UK with expertise in covalent drug discovery and Direct-to-Biology workflows. Views my own.
Stevenage
Joined March 2021
Congratulations to @HarryWilders and the team for getting this exciting ‘Direct-to-Biology’ work out there!. We generate cysteine-targeting chloroactemide reactive fragments and screen them without purification to optimise inhibitors of SARS MPro.
onlinelibrary.wiley.com
Direct-to-biology workflows promise to accelerate hit optimisation for drug discovery. Here, we describe a direct-to-biology method for the efficient synthesis and screening of cysteine-reactive...
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A pleasure to act as @JessCrompton’s Industrial Supervisor over the past year or so. She is an incredibly hard-worker and it’s wonderful to see that work rewarded with this nice publication in @JOC_OL 😊 If you need cyclopropyl acids, look no further!
pubs.acs.org
Cyclopropanes are highly useful motifs that are often incorporated into drug candidates to improve potency, metabolic stability, or pharmacokinetic properties. An expedient method for the α-cyclopr...
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RT @BurleyResearch: Our latest paper in collaboration with @GSK describes how the reactivity of a series of SuFEx reagents influences coval….
pubs.acs.org
Here, we report a comprehensive profiling of sulfur(VI) fluorides (SVI-Fs) as reactive groups for chemical biology applications. SVI-Fs are reactive functionalities that modify lysine, tyrosine,...
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RT @scottlovell34: I'm searching for a PhD student to start in my brand new lab @UniofBath in Oct 2022. The project will use phage display….
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Great to see this nice piece of work out there! . Understanding the mechanisms of bacterial drug transport is going to be crucial in the coming years for overcoming the growing #antimicrobialresistance crisis.
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RT @KRHornberger: Time for another pharmacology tweetorial, this time on the distinction between IC50 and Ki. 1/
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Nice to be at my first in-person conference in over 2 years! Hearing great talks about peptide chemistry. Looking forward to applying some of these strategies to my own work #BiologicsUK.
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RT @Jake_T_Bush: Congratulations to Ross Thomas and the team for this great work published in @ChemicalScience on accelerating PhABit desig….
pubs.rsc.org
Methods for rapid identification of chemical tools are essential for the validation of emerging targets and to provide medicinal chemistry starting points for the development of new medicines. Here,...
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RT @ChemSocRev: Have you seen 'The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directi….
pubs.rsc.org
Bacterial infections caused by ‘superbugs’ are increasing globally, and conventional antibiotics are becoming less effective against these bacteria, such that we risk entering a post-antibiotic era....
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2nd dose done! Feeling very grateful and proud to be a scientist (not that I have anything to do with vaccines…)
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Really nice paper showing synthesis of enantioenriched amides through N-alkylation rather than N-acylation using a dual copper catalytic cycle.
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Really cool paper from the @FGagosz lab. A simple and versatile route to complex bicyclic pyrroles using neutral ynamides as the 3-atom component for (3+2) cycloadditions. Don't think I've seen a neutral species used for such cycloadditions before.
pubs.acs.org
While 1,3-dipolar cycloadditions have appeared to be a fertile area for research, as attested by the numerous synthetic transformations and resulting applications that have been developed during the...
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RT @derda_lab: Grad student @JeffYKWong and co. report phage display enabled discovery of proteolytically stable bicyclic inhibitors for pr….
pubs.rsc.org
In this manuscript, we developed a two-fold symmetric linchpin (TSL) that converts readily available phage-displayed peptides libraries made of 20 common amino acids to genetically-encoded libraries...
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RT @SamanthaMay64: There are few things more joyful than watching young stoats at play. I managed to approach this family on the track at t….
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