GDEatUTSW
@GDE_UTSW
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Siegwart Research Lab | Program in Genetic Drug Engineering @ UTSW | Student-run
Dallas, TX
Joined December 2023
Congrats to Erick for presenting his poster on investigating the functional contributions of phospholipids in SORT LNPs at the 23rd International Nanomedicine and Drug Delivery Symposium! #Nanomedicine #LNPs #DrugDelivery
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Last week, Dan gave two talks at NACFC 2025 on LNP design for durable CFTR gene correction in lung stem cells and dual SORT for multi-organ base editing, advancing targeted, long-lasting gene therapies for CF and beyond! #NACFC2025 #GeneEditing #CysticFibrosis #LipidNanoparticles
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The @UTSWGradSchool and the @UTSWmstp collaborated to showcase the strengths of our programs and institution during the 2025 @UTSWMedCenter Research and Health Conference. Thank you, Maddie and Sofia, for your dedication and time. We’re truly grateful to partner with you.
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Congratulations to our lab's outstanding poster presentations at #BMES2025! Read more: https://t.co/a7Pr8rDalL
https://t.co/5FQjpfR3IF
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🎉Registered and ready for #BMES2025 @BMESociety! Stop by @utswbme Booth #315 today, 6–7:30 PM. We can’t wait to meet you, chat about your research and career interests, and share the exciting opportunities at @UTSWGradSchool @utswbme! #FollowYourSpark at @UTSWMedCenter
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🚀Congrats to Lisa and the team on our new publication in ACS Bioconjugate Chemistry! The study shows that mannose-conjugated cholesterol can guide LNPs to Kupffer cells & liver endothelial cells. Read more:
pubs.acs.org
Lipid nanoparticle (LNP) delivery of mRNA to specific cell types is a necessary task for the development of safe and effective medicines. LNP delivery to the liver is largely driven by the binding of...
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Professor of Biomedical Engineering @DJSiegwart, Ph.D., is the speaker for @UTABME's weekly seminar series this Friday, September 12 from 12-1 p.m. He will present on @GDE_UTSW's development of SORT lipid nanoparticles and SEND mRNAs.
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🚀 Congrats to Erick and the team on our new publication in Biomaterials! The study reveals how phospholipids in SORT LNPs enhance mRNA delivery via improving endosomal escape and inducing LNP morphological rearrangements. Read more: https://t.co/N4nf4xXNA5
#LNP #mRNATherapy
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This #throwbackthursday, we are throwing it back to last Friday to celebrate Graduate Student Researcher Joshua Robinson in the @GDE_UTSW Lab, who successfully defended his dissertation. Congratulations, Dr. Robinson!
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@JudgeClayJ @utswbme Thank you Judge Jenkins @JudgeClayJ ! It was an honor and pleasure to host you and your colleagues at @UTSWMedCenter @GDE_UTSW @utswbme . I look forward to working with you and our community to advance healthcare research that impacts our region and beyond.
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Great visit last week to @DJSiegwart, Ph.D., research lab at @utswbme! His groundbreaking work on lipid nanoparticles for alpha-1 antitrypsin deficiency offers hope to thousands affected by this rare genetic condition. Learn more: https://t.co/c11eoYv4t3
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🚨 Breakthrough in #GeneEditing! Congrats to Yehui Sun, winner of the 2025 Ida M. Green Award 🎉 Her pioneering work uses lipid nanoparticles + SORT delivery to correct faulty genes in 70% of lung stem cells—lasting nearly 2 years. A potential one-time treatment for CF!
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Congrats to our team on publishing in ACS Nano! We engineered LNPs to target kidney tumors via vitronectin binding, boosting mRNA delivery 952x in vitro and 42x in vivo. #CancerResearch #LNP #mRNA Read more:
pubs.acs.org
Although the delivery of genetic therapies to tumors using nanoparticles remains challenging, targeting may be enabled via plasma membrane receptors overexpressed on certain cancer cells. Here, we...
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Transforming medicine, one discovery at a time! Yehui Sun, a @UTSWGradSchool student and this year’s Ida M. Green Award recipient, is utilizing lipid nanoparticles to deliver gene-editing tools, offering hope to patients with cystic fibrosis. https://t.co/PRqTv8czoi
#MedEd
utsouthwestern.edu
Yehui Sun, a graduate student in the Siegwart Lab, has been honored with the 2025 Ida M. Green Award for research developing lipid nanoparticles that deliver molecular gene editing machinery to lung...
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Congrats to Yehui for winning the 2025 Ida M. Green Award at UT Southwestern! Her work offers new hope for cystic fibrosis patients. A true leader in science and the student community! #WomenInSTEM #GeneTherapy #LNP #UTSouthwestern Read more:
utsouthwestern.edu
Yehui Sun, a graduate student in the Siegwart Lab, has been honored with the 2025 Ida M. Green Award for research developing lipid nanoparticles that deliver molecular gene editing machinery to lung...
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🎉 Huge congratulations to our graduate student, Victoria Yang, for her publication in Nature Biotechnology on "Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes". Read more: https://t.co/pWZUiOPppj
#GeneEditing #NatureBiotechnology
nature.com
Nature Biotechnology - Ribonucleoproteins, nucleic acids and proteins are delivered into target cell types with nanosyringes.
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Our lab member Yufen @YufenXiao gave a fantastic talk on her recent publication: "High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated mRNA therapeutic delivery." at the #CRS2025! Congrats! 🎉 #mRNA #LNP
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Yehui Sun, PhD candidate in @GDE_UTSW Lab, was presented with the Ida M. Green Award on Friday, July 11 during a small reception. Congratulations to Yehui for her commitment to research excellence, the well-being of fellow students and community service!
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🚨 Exciting news! Dan is giving a talk on the development of selective organ targeting (SORT) lipid nanoparticles (LNPs) for genome correction of disease-causing mutations. @DJSiegwart @CRSScience
#CRS2025 #Nanomedicine #LNP #GenomeEditing
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