Cristobal Onetto
@CristobalOnetto
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Scientist immersed in the field of genomics and wine science. Fungi enthusiast.
Adelaide, South Australia
Joined September 2011
Cells are fast and crowded places. Numbers help us make sense of them. Here are five of my favorite "bionumbers." 1. ATP synthase spins 134 times/second. That is much faster than the propeller on most piston airplanes, and about half the r.p.m. of a Boeing 737 jet engine.
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Great @SA_genomics event last night with @nanopore @UniofAdelaide. A huge THANK YOU to our speakers (@CristobalOnetto, @jafarjabbari and Dr. Kevin Fenix) for telling us about their research. And thank you to everyone who attended.
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Can the propensity of Shiraz to develop peppery characteristics such as Rotundone be due to identifiable genomes variants? See this recent article in the Australian Journal of Grape & Wine Research published on 11 May: https://t.co/h70hlWT2Wt
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The genomic landscape of wild Saccharomyces cerevisiae is shaped by complex patterns of admixture, aneuploidy and recombination. | bioRxiv
biorxiv.org
Cultural exchange of fermentation techniques has driven the spread of Saccharomyces cerevisiae across the globe, establishing wild populations in many countries. Despite this, most modern commercial...
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Some serious psychedelic art going on here. Putting the sticker was definitely harder than doing a library 😝. @nanopore
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The AWRI has just published a reference genome for Shiraz, and intriguingly, the data point towards a genetic basis for the pepper compound, rotundone. Read the open access article in @JournalGrape here: https://t.co/b0ZykVg13z
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Happy for this work to get published. A comprehensive investigation of the relationship between copper and SO2 in S. cerevisiae. https://t.co/uIv38dgrir
journals.plos.org
Author summary Completing a commercial wine fermentation is a tough job for a yeast. Grape juice is a highly variable environment and to cope with that variability, a large number of different yeast...
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More thoughts on the demise of disruptive science. Take Fred Sanger, 2x Nobel Prize winner. Sydney Brenner wrote about him in an obituary that multiple times in Fred's career, he went 10+ years without publishing as he was working on 'disruptive' science. https://t.co/Y5JkuTPLHc
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New Nature paper provides evidence that science has become less innovative since the 1950s. The authors suggest reversing the trend by: 1. reading widely, 2. focusing less on quantity of papers, & more on research quality, 3. taking year-long sabbaticals. https://t.co/oYV5JCXRl8
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This paper is mind blowing in both its conclusions and its execution. Both conserved and rapidly evolving functions of a telomere protein unveiled by swapping it between species. End capping function conserved but TE control function changed.
elifesciences.org
Evolution strictly preserves telomere stability but rapidly diversifies telomere length regulation in Drosophila.
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And we finally have a Shiraz genome. Tonight’s glass of red is going to be tastier than ever 🍷. @nanopore making my life easier. Check out the preprint at bioRxiv https://t.co/BpcwDV7D0C
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New #wine research: Onetto et al @CristobalOnetto @The_AWRI sequence grapevine #pathogen Eutypa lata isolates They find high gene-flow & sexual recombination, demographic expansion, & dynamic secondary metabolite production #fungus #Genetics #Genomics
https://t.co/71B9yG3bYS
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10 years ago today a @ScienceMagazine online paper with an obscure title turned out to be the beginning of the most important life science breakthrough in many decades: #CRISPR genome editing https://t.co/y23NPGumVV
@carlzimmer
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A fully synthetic chromosome designed with pan-genomic elements of the baker’s yeast Saccharomyces cerevisiae. @NatureComms @nanopore @The_AWRI
https://t.co/g62bSaDGjC
nature.com
Nature Communications - The Sc2.0 consortia is reengineering the yeast genome. To expand the Sc2.0 genetic repertoire, the authors build a neo-chromosome comprising variable loci from diverse yeast...
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@CristobalOnetto from the @The_AWRI speaking about two of my favorite topics, wine and @nanopore sequencing
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'Pore' yourself a glass of wine for this talk. At #NanoporeDay, South Australia, @CristobalOnetto will discuss how the @The_AWRI are using #nanopore sequencing to improve the production of wine. Register here:
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