Start the year learning about TrkB and mGluR5 teaming up in the hippocampus, choreographing synaptic changes. BDNF and G-protein-dependent crosstalk lead the intricate dance of receptor crosstalk. Thanks to everyone that made it possible #trkb #gpcr

Given the co-expression of TrkB and mGluR5 in the nervous system and their roles in synaptic plasticity. The enhancement of TrkB-driven synaptic plasticity by mGluR5 positive allosteric modulators offers promising avenues for advanced antidepressant treatments.

1. The identified crosstalk between TrkB and mGluR5 is facilitated through the cooperative action of Gbg, released from TrkB, and Gaq-GTP, released from mGluR5. This represents a novel and physiologically significant form of RTK/GPCR crosstalk.

2. This interplay results in a distinct form of BDNF-induced synaptic plasticity characterized by sustained, oscillatory Ca2+ signaling and enhanced MAP kinase pathway activation.

1. Our research describes a new RTK/GPCR crosstalk wherein mGluR5 amplifies TrkB effects to modify downstream signaling dynamics, leading to a unique form of BDNF-induced synaptic plasticity.

I am happy to share a pre-print about my project at at Dr. Francis Lee's Lab on a novel form of synaptic plasticity. Please don’t be shy and share your feedback. All this work was possible to an amazing team, thanks to @JihyeKimMD and the rest of the team

Proud to be part of this team 🥰

A class of #Alzheimers drugs that aims to slow cognitive decline, including the antibody lecanemab that was granted accelerated approval in the United States in January, can cause brain shrinkage, researchers report.

Happy International Women's Day! We're celebrating women who have changed the world. Here's all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award. Who are the women who inspire you the most? #IWD2023

Honored and excited to take on this Chair and advance our understanding of the relationship of physical and emotional trauma to mental health.

#UCalgary announces Dr. Matthew Hill as inaugural Chair of Mental Health Initiative for Stress and Trauma, exploring how the brain reacts to physical and emotional stressors https://t.co/ccL06lzy8O @HotchkissBrain @UCalgaryMed @UofCr4kids

Wow - Roche has announced that in addition to a new trial of tominersen, it is working on TWO different approaches - a small molecule huntingtin splicing modulator (a bit like PTC518) and a mutant-only huntingtin-lowering ASO (like the Wave approach)

Congratulations to Dr. Francis Lee on his appointment as the new interim Stephen and Suzanne Weiss Dean of Weill Cornell Medicine! @wcmresearch #weillcornellmedicine #werechangingmedicine

Anthony Fauci has become one of the most recognizable physician-scientists in the world. For a new #ScienceEditorial, @hholdenthorp sat down with the outgoing #NIAID director to talk about the challenges facing science and his plans for the future. https://t.co/YH4Zzcmwhk

Please RT. #Postdoc and Research Tech positions open @RajadhyakshaLab to study #addiction in animal models. Genetics, molecular, circuits, behavior. DM me.

🔴 Irrespirable + peligroso el aire y humo ahora mismo en Granada 😷 #Incendio #Granada #Guajares

Epstein-Barr Virus May Be Leading Cause of Multiple Sclerosis The risk of developing mutliple sclerosis increases 32 fold following Epstein-Barr virus infection. #multiplesclerosis #neuroscience #science #neurology https://t.co/TFbxbhDtNy

A new Science analysis of data from U.S. military recruits suggests multiple sclerosis—a disease considered of unknown etiology—is a complication of infection with Epstein-Barr virus. Learn more ⬇ https://t.co/cxayFOyU9n #SciencePerspective: https://t.co/DJvxFxMc5X

A pyramidal tract neuron in frontal cortex. That apical dendritic tuft 🔥. from Lingxiao Shao in the lab. Happy #FluorescenceFriday !

¿Ya te has dado cuenta de que no vas a enviar el paper antes de Navidad?