Start the year learning about TrkB and mGluR5 teaming up in the hippocampus, choreographing synaptic changes. BDNF and G-protein-dependent crosstalk lead the intricate dance of receptor crosstalk. Thanks to everyone that made it possible #trkb #gpcr

Given the co-expression of TrkB and mGluR5 in the nervous system and their roles in synaptic plasticity. The enhancement of TrkB-driven synaptic plasticity by mGluR5 positive allosteric modulators offers promising avenues for advanced antidepressant treatments.

1. The identified crosstalk between TrkB and mGluR5 is facilitated through the cooperative action of Gbg, released from TrkB, and Gaq-GTP, released from mGluR5. This represents a novel and physiologically significant form of RTK/GPCR crosstalk.

2. This interplay results in a distinct form of BDNF-induced synaptic plasticity characterized by sustained, oscillatory Ca2+ signaling and enhanced MAP kinase pathway activation.

1. Our research describes a new RTK/GPCR crosstalk wherein mGluR5 amplifies TrkB effects to modify downstream signaling dynamics, leading to a unique form of BDNF-induced synaptic plasticity.

I am happy to share a pre-print about my project at at Dr. Francis Lee's Lab on a novel form of synaptic plasticity. Please don’t be shy and share your feedback. All this work was possible to an amazing team, thanks to @JihyeKimMD and the rest of the team.

Proud to be part of this team 🥰.

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