Jesus Corria-Osorio
@CorriaJesus
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MD PhD Oncoimmunologist @Ludwig_Cancer @OncoUNILCHUV Proud Cuban, proud physician, developing next-generation ACT for cancer immunotherapy in Switzerland
Lausanne, Switzerland
Joined April 2019
RT @GCIR_Unige: #ID2024 Immunology Day in Geneva is happening now! . We're enjoying great presentations from biotech & @unige_en research g….
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RT @IanParish_AU: Big thanks to Katharine Block & Steve Jameson @Jamequistlab for this brilliant and thoughtful commentary on our recent @I….
cell.com
The mechanisms that make and break CD8+ T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8+ T cells rapidly adopt an epigenetically...
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RT @EricTopol: "The maximal lifespan [of people and 347 mammalian species] is strongly associated with an epigenetic signature that is larg….
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RT @LabWaggoner: Cellular architecture is a predeterminant of early TCR signaling and subsequent cell fate decisions of individual naïve T….
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RT @carmonation: The under-appreciated non-linear effects of transcription factors dosing on cell fate. Fascinating work presented by @Bart….
biorxiv.org
Reprogramming approaches often produce heterogeneous cell fates and the mechanisms behind this heterogeneity are not well-understood. To address this gap, we developed scTF-seq, a technique inducing...
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RT @carmonation: Happy to share an exciting work from the lab in collaboration with François Kuonen and team!.Many studies have established….
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RT @neuromichael: Previously unseen details of human brain structure revealed. Featured image: a single neuron with ~5,600 of the nerve fib….
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RT @oncodaily: The results of our study on the effect of prostaglandin E2 on T cells - @MMorotti (@Ludwig_Cancer / @chuvlausanne). https://….
oncodaily.com
Matteo Morotti: The results of our study on the effect of prostaglandin E2 on T cells / Alexandre Harari, Alizee Grimm, Alizee J. Grimm, antitumour potential,
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RT @JBoettcherLab: We are thrilled that our study on PGE2-mediated impairment of TCF1+ stem-like CD8+ T cell responses in cancer, with (tw….
nature.com
Nature - Tumour-derived prostaglandin E2, signaling through its receptors EP2 and EP4, is shown to restrain the responses of tumour-infiltrating stem-like TCF1+CD8+ T lymphocytes, and...
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RT @MMorotti: Proud to share the results of our study on the effect of prostaglandin E2 on T cells, which was just published in Nature in w….
nature.com
Nature - Prostaglandin E2 from the tumour microenvironment impairs interleukin-2 sensing by tumour-infiltrating lymphocytes, restricting proliferative response and promoting T cell death via...
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RT @EvanWeberPhD: Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors dri….
nature.com
Nature - The transcription factor FOXO1 has a key role in human T cell memory, and manipulating FOXO1 expression could provide a way to enhance CAR T cell therapies by increasing CAR T cell...
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RT @OncoUNILCHUV: 💡NEW study from Barras et al. in melanoma patients shows T cell-myeloid cellular networks mediate response to adoptive T….
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RT @carmonation: In most biomedical studies that use single-cell omics, the biological replication unit is the whole sample/tissue and not….
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Semi-supervised integration of single-cell transcriptomics data | Nature Communications. A great scRNAseq Integration tool. Highly recommended .
nature.com
Nature Communications - Batch effects hinder multi-sample single-cell data analyses. Here, authors present STACAS, a scalable single-cell RNA-seq data integration tool that uses prior cell type...
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RT @carmonation: Happy to share the peer-reviewed version!⛺️.Now including additional analyses of i) impact of celltype composition imbalan….
nature.com
Nature Communications - Batch effects hinder multi-sample single-cell data analyses. Here, authors present STACAS, a scalable single-cell RNA-seq data integration tool that uses prior cell type...
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RT @carmonation: In scRNA-seq analysis, "overcorrection" of batch effects is a frequent cause for loss of important biological variability.….
biorxiv.org
Single-cell sequencing technologies offer unprecedented opportunities to characterize the complexity of biological samples with high resolution. At the same time, variations in sample processing and...
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