Colin Nichols Lab @colinnicholslab.bsky.social
@ColinNicholsLab
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Posting from Colin Nichols' electrophysiology lab at @WUSTL. Focused on ion channels biophysics & role in physiology and pathology.
Saint Louis, Missouri
Joined March 2023
Follow us on @bluesky ! https://t.co/TmX4i9j5kF
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Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome @vesselman @ColinNicholsLab @JCI_insight
https://t.co/2qDAflvnTq
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The study has important implications both for monogenic KATP channel diseases and for more common brain pathologies. 4/n
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We reveal the dramatic effects of either increasing or decreasing SUR2/Kir6.1-dependent KATP activity on NVC, whether pharmacologically or genetically induced. 3/n
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In this study, we demonstrate the striking role of SUR2- and Kir6.1-dependent ATP-sensitive potassium (KATP) channels in control of NVC in the sensory cortex of conscious mice, in response to mechanical stimuli. 2/n
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Check out our new publication "Control of neurovascular coupling by ATP-sensitive potassium channels" @Nyorkster91 @SageJournals
https://t.co/A5SsHdzAZu A 🧵 1/n
journals.sagepub.com
Regional blood flow within the brain is tightly coupled to regional neuronal activity, a process known as neurovascular coupling (NVC). In this study, we demons...
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We show that insulin secretion can be restored when intracellular Ca2+ is artificially elevated by increasing extracellular Ca2+. 4/n
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In this study we examine this phenomenon, demonstrating that the lack of insulin secretion is the result of an apparent reduced sensitivity to Ca2+. 3/n
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While loss of function mutations in KATP have been associated with insulin hypersecretion, KATP KO animals exhibit reduced secretion and glucose intolerance. 2/n
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Check out our new publication "Loss of β-cell KATP reduces Ca2+ sensitivity of insulin secretion and Trpm5 expression" @Nyorkster91 @ADA_Pubs
https://t.co/HlYykfxmrf A 🧵 1/n
diabetesjournals.org
Loss-of-function mutations in ATP-sensitive potassium (KATP) channels cause hyperexcitability and insulin hypersecretion, resulting in congenital hyperinsu
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Excellent thesis defense by Dr. Gao! Congratulations Jian, we are very proud of you! 🥳
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Congratulations to Drs. Irfan Lodhi, Jeffrey Millman, Maria Remedi, and Julie Silverstein on achieving full professorship in their careers! Learn about each of their journeys: https://t.co/tikXeoPGLY.
@JeffreyRMillman @LodhiLab @WUDeptMedicine
endocrinology.wustl.edu
Congratulations to Irfan Lodhi, PhD; Jeffrey R. Millman, PhD; Maria S. Remedi, PhD; and Julie M. Silverstein, MD of Washington University’s Division of Endocrinology, Metabolism and Lipid Research …
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The specific location of the variant also reveals an unrecognized functional role of the first glycine in the signature motif of the nucleotide binding domains in NBD1 of SUR2 subunits. 4/n
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