Slav Bagriantsev
@SlavBagria
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Philosopher / Wizard, Yale University.
New Haven, CT
Joined July 2017
This October I’m drawing 1 molecule a day inspired by proteins in pdb @buildmodels #Inktober2025 Day 17/31 Prompt ORNATE Pdb: 9MME For the Escher fans! An ornate molecular cage made entirely of RNA. Next: DEAL Suggestions?
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This October I’m drawing 1 molecule a day inspired by proteins in pdb @buildmodels #Inktober2025 Day 15/31 Prompt RAGGED Pdb: 2W8M A rugged nuclease D212 from a virus that preys on archaea in the scalding waters of hot springs. Next: BLUNDER Suggestions?
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Our new paper is finally out today. An exciting collaboration with the Buhrlage lab. We report an allosteric activator of USP7. https://t.co/FPLPWt3jWI
pnas.org
Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and o...
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This October I’m drawing 1 molecule a day inspired by proteins in pdb @buildmodels #Inktober2025 Day 13 Prompt DRINK Pdb: 7BTW A pair of mitochondrial outer membrane β-barrel SAM complexes from Saccharomyces cerevisiae, the yeast used to make beer. Next: TRUNK Suggestions?
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Researchers investigated aging mechanisms in the nervous system and found that glial alkalinization caused by the loss of the pH-regulating CLH-1 channel promotes longevity, increases stress resistance, minimizes neuronal damage, and prolongs health. https://t.co/xBddcfCtAL
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This October I’m drawing 1 molecule a day inspired by proteins in pdb @buildmodels #Inktober2025 Day 12 Prompt SHREDDED Pdb: 6TUB β-Endorphin. The protein precursor POMC is shredded by proteases into multiple peptide hormones, including β-endorphin. Next: DRINK Suggestions?
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This October I’m drawing 1 molecule a day inspired by proteins in pdb @buildmodels #Inktober2025 Day 11 Prompt STING Pdb: 6MZT Scorpion venom protein Urotoxin. Next:SHREDDED Suggestions?
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This October I’m drawing 1 molecule a day inspired by proteins in pdb @buildmodels #Inktober2025 Day 10 Prompt SWEEP Pdb: 7NAP Proteasome: the cleanup machine. It breaks down damaged or unneeded proteins, keeping the cell neat and efficient. Next: STiNG Suggestions?
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This October I’m drawing 1 molecule a day inspired by proteins in pdb @buildmodels #Inktober2025 Day 9 Prompt HEAVY Pdb: 4DL6 Heavy metal therapy. Platinum-based cancer drug cisplatin damages DNA but DNA polymerase eta copies it past the lesion. Next: SWEEP Suggestions?
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Our paper in @ScienceAdvances. The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in C. elegans #aging #Huntington #stress #alkalinity #glia #autophagy #ionchannel #pH
science.org
Alkalinization of glial cells mediates longevity, stress resistance, and protection from polyQ aggregation in C. elegans.
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Our latest paper is out ahead of print in PNAS today. Check it out and spread the word. https://t.co/6ZMT2prqN8
pnas.org
Hao–Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7)...
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Fish somatosensory system detects pressure, velocity and vibrations without the receptors typical of amniotes. Our new story by Ke Tan. Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system. https://t.co/Ly69TVT5R6
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Octopuses sense environmental microbiomes to drive predatory and parental behaviors. Artwork by Lily Soucy. #evolution #sensation #microbiome @CellPressNews
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Molecular mechanism of activation of kainate-subtype ionotropic glutamate receptor GluK2 in complex with auxiliary subunits Neto2. In both closed/apo and open states, ligand-binding domain layer has 2-fold symmetry! @shantigangwar @MariaKarela3 @LauraYen42
https://t.co/r4RWqXB5rV
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Happy to share structures of kainate receptor channel GluK2 in complex with auxiliary subunits Neto2, which slow receptor kinetics, in apo closed and open conducting states, both with 2-fold symmetrical LBD layer! @shantigangwar @MariaKarela3 @LauraYen42
https://t.co/r4RWqXAxCn
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New drawing! Ubiquitin-specific protease 7 (pdb 4M5W) It’s been a while since I last drew anything. Forgot how fun it is.
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@CoreyAHAllard et al asks how “solar-powered” slugs maintain stolen chloroplasts from their diet for photosynthesis and starvation resistance. @CellPressNews, @MCB_Harvard, @harvardmed
https://t.co/6dllQEtSAR
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More from Rebecka Sepela on how octopuses sense environmental microbiomes to drive predation and material care behavior: https://t.co/mtBZppgJbJ
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