Dmitriy M Chudakov
@ChudakovM
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Structure-based prediction of T cell receptor recognition of unseen epitopes using TCRen. Yes, it works: https://t.co/A2XJe9Erbt
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And one more manuscript from our team, also focussed on Treg. Purely repertoire-based as we like)) Beautiful (!) data from Prof. Rudensky. Long work, short read.
pubmed.ncbi.nlm.nih.gov
Suppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II. However, it...
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Happy to report our development for scRNA-Seq analysis. Employs splicing information at the level of clustering and dimensionality reduction. Readily revealed beautiful aspects of Treg and Th1/CD4+ cytotoxic biology. Try!
biorxiv.org
Single-cell RNA sequencing (scRNA-Seq) provides invaluable insights in cell biology. Current scRNA-Seq analytic approaches do not distinguish between spliced and unspliced mRNA. RNA velocity paradigm...
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Targeted depletion of TRBV9+ T cells induces remission in a single ankylosing spondylitis patient, with significant improvements in functional and mobility metrics #Immunotherapy #AnkylosingSpondylitis
nature.com
Nature Medicine - Targeted depletion of TRBV9+ T cells induces remission in a single patient with ankylosing spondylitis, with significant improvements in functional and mobility metrics.
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We started this work ~15 years ago. Now it is on the 2nd phase clinical trial. With all the circumstances, things evolve towards new generation immunotherapies, to make life happier on our small fragile planet.
Targeted depletion of TRBV9+ T cells induces remission in a single ankylosing spondylitis patient, with significant improvements in functional and mobility metrics #Immunotherapy #AnkylosingSpondylitis
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Spectacular finding from Dmitryi Chudakov group (time to get a Twitter handle!) @CEITEC_Brno. Blind moles are special, they #live #long and prosper, now we know, at least in part, why. It goes down to the organisation of their adaptive #immune #system. 👏
Izraelson et al. @CEITEC_Brno, @immunology_s reveal that the adaptive immune system of the long-lived blind mole rat is organized differently over its lifespan from other rodents. Read it here:
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Great Misha's work
Our collaborative project (@pogorely, @elisarosix, @BensoudaMeriem, @an_franke, @ChudakovM and others) about longitudinal #TCR repertoire sequencing after #SARSCoV2 infection is now also on biorxiv. https://t.co/LtcOmFJPth
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https://t.co/qwRbiiyhm5 Admiration, envy, hope, inspiration ... altogether. And love for Andrew Sewell and his way of thinking. Ultimately - inspiration.
nature.com
Nature Immunology - Identifying selective tumor-associated molecules that can act as targets for T cells is a major goal of immunotherapy. Sewell and colleagues demonstrate that the nonclassical...
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https://t.co/XaV37HvsCq Yet many things unclear, but was a great pleasure to dig. SupplTable1 tries to summarize clinically relevant things, some controverisal. Great work by George Sharonov. Intersting what people say on IgG1/IgG3 difference hypothesized on Fig. 3.
nature.com
Nature Reviews Immunology - This Review discusses the various ways in which B cells, plasma cells and antibodies shape the immune response in cancer. B cells can have both protumour and antitumour...
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TCGA RNA-Seq analysis reveals strong association between Tumor-infiltrating B-cell antibody isotypes and survival in lung adenocarcinoma carrying specific driver mutations. https://t.co/OwWCnPZbxq
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Comprehensive analysis of antiviral adaptive immunity formation and reactivation down to single-cell level
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Our latest study on immune responses to the flu vaccine and B cell memory in human tissues is out today and featured on the cover of @ScienceTM! @TheDohertyInst @UniMelbMDHS
https://t.co/EnzG1u34rY
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CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients https://t.co/wFtYgjhVPi
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New from Andrew Sewell lab: "Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations" https://t.co/bWTqXfV167
@J_Immunol
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Story of Alexander (Sasha) Rudenksy, recipient of 2018 #VilcekPrize in Biomedical #Science, discoverer of regulatory T cells #FOXP3 #Tregs
https://t.co/A8gpurY7Ux
@UW @HHMINEWS @sloan_kettering @Ludwig_Cancer @UWalum #Proudimmigrant #UWalmamater #immunology
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Antigen receptor repertoire profiling from RNA-seq data
nature.com
Nature Biotechnology - Antigen receptor repertoire profiling from RNA-seq data
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T cell immunity does not age in a long-lived rodent species
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