MAMATHA CHIVUKULA,MD,FASCP
@ChivukulaMd
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“Making life better for others than yourself “ Passions - my work and my running
Burlingame, CA
Joined February 2017
Immensely Proud of @carley, Anna Marie, MD, former fellow @UPMCnews @magee women’s Hospital of UPMC 👏🏼 https://t.co/T7H5ZPZTRV
thelibrarydistrict.org
Artist Statement: Connection to both nature and community is essential for the human condition. Modern society has a new virtual…
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Interesting data ..
Just out @Nature The 1st whole-slide digital pathology #AI foundation model pre-trained on large-scale real-world data, from over 1.3 billion images, 30,000 patients https://t.co/K3mKkHPdtu
@hoifungpoon @HanwenXu6 @Microsoft @UW @naotous @MSFTResearch
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Vamos @carlos Alcaraz @Wimbledon 🏆👏🏼🎉🎊at 20 yrs
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Thank you ; muchas Gracias 🙏🏽to all Medical Laboratory Professionals @rex_mls @ASCP_Chicago #National lab week 🔬🧪🧫
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There are differences in QIA approach. Some analyze areas of interest. Some analyze the whole tumor area. Some algorithm trained to adjust the HER2 FISH data.
Q7: What can we learn from the quantitative image analysis (QIA) studies evaluating HER2 interpretation? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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#her2low CAP guidelines on QIA of HER2 IHC were published in 2019
Q7: What can we learn from the quantitative image analysis (QIA) studies evaluating HER2 interpretation? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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@ASCP_Chicago @DrBuiPathology @ChivukulaMd @KhouryThaer A7: Since interobserver variability still occurs, QIA offers an objective and reproducible scoring method #HER2low #PathTwitter #BreastPath
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#her2low sTudies of QIA have shown reduced equivocal cases of HER2
@ASCP_Chicago @DrBuiPathology @ChivukulaMd @KhouryThaer A7: Since interobserver variability still occurs, QIA offers an objective and reproducible scoring method #HER2low #PathTwitter #BreastPath
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#her2low micro- papillary carcinoma retraction can be over scored by HER2 IHC
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A2: Future HER2 evaluation may include RNA-based methods such as RT-qPCR #HER2low #PathTwitter #BreastPath
Q2: What were some highlights from the recent review article “Emerging Landscape of Targeted Therapy of Breast Cancers with Low HER2 Protein Expression”? https://t.co/aj6osbCwsQ
#HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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#HER2low Daisy trail results presented at SABCS2022 and investigators found T-Dxd has clinically meaningful activity in HER2 positive, HER2low and HER2 zero advanced breast cancer,#breast path
Q6: What are some of the ongoing HER2-low breast cancer trials for patients? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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#her2low 4B5
A4. We did a survey study to identify the most commonly used antibodies, 4B5 came on top, which is the only FDA approved companion diagnostic indicated to identify HER2-low status in patients with metastatic breast cancer. #HER2low #PathTwitter #BreastPath
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A4. We did a survey study to identify the most commonly used antibodies, 4B5 came on top, which is the only FDA approved companion diagnostic indicated to identify HER2-low status in patients with metastatic breast cancer. #HER2low #PathTwitter #BreastPath
Q4: Which HER2 antibody assay(s) do you use in your lab? What is required to switch to a new assay or to run multiple assays in the lab? How are these assays different? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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A4: Another comparison of HercepTest and Pathway 4B5: more tumors were overscored as IHC 2 + by HercepTest https://t.co/s10PHXQOJ1
#HER2low #PathTwitter #BreastPath
Q4: Which HER2 antibody assay(s) do you use in your lab? What is required to switch to a new assay or to run multiple assays in the lab? How are these assays different? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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A4: Recent abstract from AACR about proficiency assessment of HER2-low scoring using different assays https://t.co/VroKbUtvy4
#HER2low #PathTwitter #BreastPath
Q4: Which HER2 antibody assay(s) do you use in your lab? What is required to switch to a new assay or to run multiple assays in the lab? How are these assays different? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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Q5: #her2low thin sections may result in false negative results of HER2
Q5: How do preanalytic and analytic variables impact the quality of HER2 testing? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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Q4: beware of crush and edge artifacts scoring HER2 by IHC #her2low
Q5: How do preanalytic and analytic variables impact the quality of HER2 testing? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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Q4: prolonged cold ischemic time can reduce HER2 IHC staining #her2low
Q5: How do preanalytic and analytic variables impact the quality of HER2 testing? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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Q5: How do preanalytic and analytic variables impact the quality of HER2 testing? #HER2low #PathTwitter #BreastPath
@DrBuiPathology @Baskotacytopath @ChivukulaMd @KhouryThaer
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