Childers Lab
@ChildersLab
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We apply biochemistry, synthetic biology, and chemical biology to study how phase separation organizes the bacterial cytoplasm and how bacteria make decisions.
Pittsburgh, PA
Joined August 2018
Together with Michael Collins, @schraderlab, @DylanTomares, @iamvidyadhar we examined how the phase separation of BR-bodies is logically wired to the enzymatic functions of a key client - PNPase
nature.com
Scientific Reports - RNase E biomolecular condensates stimulate PNPase activity
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RT @_SaraMolly: New Preprint Out from the Molinari Lab!.We’re thrilled to share our latest work on engineered living materials in collabora….
biorxiv.org
Microbial fermentation provides a renewable route to a wide portfolio of fuels, chemicals, and therapeutics, yet product recovery is still dominated by energy-intensive biomass-removal operations....
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RT @fried_lab: Just presented for the first time today by April @ProteinSociety who received their young investigator award! #ProudPI #Frie….
biorxiv.org
The native states of globular proteins are typically viewed as being the most stable conformations on their respective proteins’ soluble free energy landscapes. This view, known as the Thermodynamic...
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RT @davidrliu: I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthro….
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RT @Pitt_Chemistry: Congratulations to the recipients of our department's inaugural best paper awards! This round of awards recognizes out….
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RT @CmuScience: Carnegie Mellon biologists have discovered the mechanism behind telomere elongation, which has implications for treating ca….
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RT @arohan_s: Many thanks to @APSPhysiology #TPhysMag for featuring us in this month's "Under the Microscope". Was fun to do this intervi….
physiology.org
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RT @angew_chem: Controlled Protein-Membrane Interactions Modulate Self-Organization of Min Protein Patterns (Katja Zieske and co-workers) @….
onlinelibrary.wiley.com
Self-organization of proteins is a fundamental process in living systems. The Zieske research group at the Max Planck Institute for the Science of Light in Erlangen now reconstituted snowflake-like...
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RT @lingchongyou: 1. Excited to share our new study, just published in Cell. First off, link to paper:
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RT @SaurabhLabNYU: 🔬🦠 Read our latest review in @PLOSPathogens on bacterial condensates, their role in stress sensi….
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RT @MuirLab: Check out our latest paper in @nchembio, where we developed our CAGE split intein platform to study signaling events using pro….
nature.com
Nature Chemical Biology - Time-resolved synthesis of target proteins via proximity-triggered protein trans-splicing has now been shown to enable the activation of a diverse set of proteins upon the...
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RT @MoffittLab: So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulat….
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RT @ThanbichlerLab: Membrane binding properties of the cytoskeletal protein bactofilin. We characterize the membrane-binding motif of bacto….
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RT @RSocPublishing: Published in #OpenBiology: Bacterial division ring stabilizing ZapA versus destabilizing SlmA modulate FtsZ switching b….
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RT @C__Ellison: Excited to share my lab’s first preprint! We found that increasing DNA binding by type IV pili in an Acinetobacter pathogen….
biorxiv.org
Bacteria take up environmental DNA using dynamic appendages called type IV pili (T4P) to elicit horizontal gene transfer in a process called natural transformation. Natural transformation is widesp...
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RT @ChemEurope: Pick of the Week, out #OpenAccess in @ChemSystemsChem by @ChildersLab:. Biomolecular Condensates: From Bacterial Compartmen….
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RT @DDasLab: Just online @NatureComms cationic peptide nanotubes can bind weak hydride transfer agents to facilitate efficient reduction of….
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RT @ChemSystemsChem: Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter-to-Li….
chemistry-europe.onlinelibrary.wiley.com
This review examines discoveries of biomolecular condensates as compartments in bacteria. Insights from bacterial cell biology and systems chemistry reveal intricate connections between chemical...
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RT @JenalLab: Our c-di-GMP sensor story is finally out in @NatureComms: Including new data demonstrating cdGreen2….
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RT @JacobsWagnerLab: Thrilled to share our latest preprint about asymmetric division in E. coli! Work led by the amazing @ThappetaYashna &….
biorxiv.org
Bacteria often experience nutrient limitation in nature and the laboratory. While exponential and stationary growth phases are well characterized in the model bacterium Escherichia coli , little is...
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RT @ShorterLab: Proteomic composition of eukaryotic and bacterial RNA decay condensates suggests convergent evolution: .
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