Johannes Kaesmacher
@CheesemakerMD
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INR/Clinician scientist @inselgruppe @ScanNeuroradBE | Neurovascular Research Team | Stroke
Bern
Joined November 2019
🚀Breaking news🚀We would like to welcome the @DOIT_trial study teams in Ulm, Leipzig, Ludwigshafen, and Bad Neustadt to the @DOIT_trial community!🥳 we are thrilled to have you on board, actively screening and recruiting patients!
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This topical review by Campbell et al. discusses the optimization of #stroke reperfusion trials, key imaging research priorities, and improved definitions for macro vs microvascular reperfusion. https://t.co/XZC21WAUZQ
@GeorgeHarston @PoojaKhatriMD @FishingNeurons @NguyenThanhMD
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Presented at #SVIN25: CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: https://t.co/ZHLCV9ukNU Editorial:
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🧠Study of patients who underwent intracranial stenting after EVT found no differences between those with vs. without IVT in: 🗓️90-day mRS shift 🗓️90-day mortality 🕐 24h sICH rates Read more here👇 https://t.co/n24CGgcs2P
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Excelente oportunidade e grande iniciativa!! 👏👏👏 @sheilambrasil @FishingNeurons
📣 Calling all stroke specialists in Latin America! Join us in São Paulo, Dec 2–5 2025, for the first Latin America Stroke Summer School from University of Bern in partnership with Rede Brasil AVC and ESO, endorsed by WSO. 🎥 Check out Urs Fischer’s invitation and get ready for
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The DO-IT study is gaining momentum in Europe, and Canada is next! 🇨🇦 Are you ready to DO IT? 👍💪💉
🔊 Exciting DO-IT Trial Update!🔊 📈 🌍 The trial continues to expand, with 24 sites actively recruiting across Europe and 33 patients enrolled so far! - 27 in🇨🇭 - 3 in the 🇳🇱 - 2 in 🇧🇪 - 1 in 🇪🇸 👏 A big thank you to everyone contributing! 💉🧑⚕️Recruit. Care. Cure. DO-IT!
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In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone. DO NOT ADD ASS TO (D)OAC for chronic CAD https://t.co/gD41INxSv0
nejm.org
Original Article: Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC trial) https://t.co/vHYyFalktf
#Cardiology
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🔊 Exciting DO-IT Trial Update!🔊 📈 🌍 The trial continues to expand, with 24 sites actively recruiting across Europe and 33 patients enrolled so far! - 27 in🇨🇭 - 3 in the 🇳🇱 - 2 in 🇧🇪 - 1 in 🇪🇸 👏 A big thank you to everyone contributing! 💉🧑⚕️Recruit. Care. Cure. DO-IT!
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Cancer-related strokes are difficult to manage, synonym of bad prognosis and still poorly understood, which is why I did my clinical PhD on this exciting topic. It is now published online, check it out!😉: https://t.co/MXBX4F0WMR
@StrokeBern @MedFacultyUniBE
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🚨new paper! Should stroke patients with tandem lesions undergo stenting during EVT? And does prior IVT matter? Find out below 👇 https://t.co/22yxXNbLDq
#stroke
@manonkappelhof @kiliantreurniet @CheesemakerMD @FishingNeurons
ahajournals.org
BACKGROUND: Equipoise persists whether patients with stroke with carotid tandem lesions undergoing endovascular treatment (EVT) should undergo acute carotid stenting, and whether intravenous thromb...
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Please apply
📢 Postdoc opening working with routine health data and clinical trial data in Bern, Switzerland. The candidate should also have interest in meta-research. See
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This graph sums it up. In acute stroke with tandem lesions (ICA + intracranial occlusion), acute carotid stenting during EVT was associated with better 90-day outcomes than EVT without stenting. Outcomes were similar with or without prior IV thrombolysis (IVT). Caveat:
Acute Carotid Stenting for Tandem Lesions in Patients Randomized to Endovascular Treatment With or Without Thrombolysis: Results From the IRIS Individual Participant Data Meta-Analysis | Stroke
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Disappointing negative outcome from the THEIA trial of IV alteplase vs aspirin in CRAO, albeit underpowered. Similar outcomes reported at ESOC 2025 in the yet published TenCRAOS trial of IV tenecteplase. Is intra-arterial thrombolysis the answer here? 🤔 https://t.co/aEW7NxBhNQ
thelancet.com
Intravenous alteplase administered within 4·5 h of CRAO onset was not associated with a significant improvement in visual acuity compared with aspirin, despite a higher rate of improvement in the...
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🚨Exciting DO-IT Trial Update!🚨 Co-funding has been granted from PHRC-N for France. A big thank you to Guillaume Turc and their teams for this great accomplishment.
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Acute Carotid Stenting for Tandem Lesions in Patients Randomized to Endovascular Treatment With or Without Thrombolysis: Results From the IRIS Individual Participant Data Meta-Analysis | Stroke
ahajournals.org
BACKGROUND: Equipoise persists whether patients with stroke with carotid tandem lesions undergoing endovascular treatment (EVT) should undergo acute carotid stenting, and whether intravenous thromb...
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The October episode of the #StrokeAlert Podcast is now available. Host @NAsdaghi highlights articles in the Oct. issue of #Stroke and interviews @TotoMynell on "Intravenous Thrombolysis in Patients With Recent Intake of Direct Oral Anticoagulants." https://t.co/xgnRbPibfh
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✨September was a busy and successful month for the @DOIT_trial ✨Another 3 centers are now active and recruiting.🎉 Thank you to the trial teams in Valladolid, Leuven, and Schleswig! We are thrilled to have you on board and welcome you to the @DOIT_trial and community.
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Bridging thrombolysis with tenecteplase versus endovascular thrombectomy alone for large-vessel anterior circulation stroke: a target trial emulation analysis https://t.co/11RLfw3xAi
jnnp.bmj.com
Background Whether bridging thrombolysis with tenecteplase is beneficial compared with thrombectomy alone in patients who had a stroke with large-vessel occlusion remains unclear. Methods This is a...
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