Achillefs Kapanidis
@AchillesKap
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Chemist who uses physics to study biology. Likes gene machines - preferably, one molecule at a time. Loves music, singing, cycling, his twins. Views? AK's own!
Oxford, England
Joined December 2016
We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.
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First post in a looong time but with our wonderful NAR story led by brilliant duo Anna and Abhishek, I could not resist! Great example of how sequence control function - here, in transcription. Seeing also this long awaited conformational change in real-time is special.
A small structural module blocks the path of nascent RNA during early transcription. Our work uncovers mechanisms for its displacement. Read more: ⤵️ @AchillesKap @anna_wang692 @Impratip96 #smFRET #transcription #proteindynamics
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The role of bacterial metabolism in antimicrobial resistance https://t.co/oIOX2QtfUR
nature.com
Nature Reviews Microbiology - In this Review, Ahmad et al. examine how antibiotics influence bacterial metabolism and how metabolism, in turn, affects drug efficacy and the emergence and evolution...
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So happy to see this AMR-related story from our 3-way collab!! Huge congrats to Alison + team, and thanks to @oxmartinschool.bsky.social for supporting it. Basic idea: deep "learning" ribosome distributions after antibiotic treatment rapidly classifies cells as resistant or not.
Our work on rapid detection of antibiotic resistant and susceptible cells using ribosome phenotypes is out today! We used fluorescent imaging and changes in bacterial structure to classify single cells with high accuracy. @AchillesKap @oxmartinschool
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Last call before its gone! Apply by Nov 25th...
We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.
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2 weeks to go! Apply for the 2 posts by Nov 25th - pls RT!
We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.
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We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.
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Cool paper from Peng Chen's lab with evidence (from tracking in live cells) for bacterial microdomains related to transcriptional regulation... Cellular Memory effects of transcription regulator−DNA interactions in bacteria | PNAS
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The buzz is still on! We had an A-M-A-Z-I-N-G time at SMolBac3 - exciting discoveries, cool new methods, lively debate at a Cotswolds setting. Thanks to all who joined and CU in 2-3 years for IV! 👍👍 @BiochemSoc for co-organising!
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11 days to go, **still some spaces left**! Great opp to hear the latest s-mol work in bacteria, network and pick up new techniques. Great location too - colleagues RT!
3 weeks to go... send us your single-molecule bacterial stories for our Cotswolds get-together!
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Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance | PNAS
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A whole lotta coupling (in Pol-II txn) going on.... RNA polymerases reshape chromatin architecture and couple transcription on individual fibers: Molecular Cell
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3 weeks to go... send us your single-molecule bacterial stories for our Cotswolds get-together!
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Self-quenched fluorophores attached to short DNA labels increase signal/resolution and reduce background in DNA-PAINT and DNA-STED. We are glad that this follow-up story (more fluors) is now out in JPC. Thank you @JPhysChem and our great Editor @JulieBiteenLab 🙏 @goetheuni
Self-quenching of organic fluorophores in short DNA oligonucleotides - brighter probes for protein labeling in super-resolution microscopy @HeilemannLab #SMLM #DNAPAINT #STED
https://t.co/yUqiQ17LIg
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What a location to start collaborations in bacteriology!
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Great speakers = great conference! Abstracts due July 30th... make your plans!
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New preprint! Congrats to @alisonefarrar for superb work on turning "ribosome maps" into a way to detect #antibioticresistance quickly! One more fruit from our "collaborative tree" (with @CNellaker & Nicole Stoesser @ModMedMicro) planted using @oxmartinschool seeds!
Can we tell whether a bacterial strain is sensitive or resistant to an antibiotic in 30 minutes, with a single image? Ribosome phenotypes let us see intracellular changes associated with antibiotic resistance in 1 image. #antibioticresistance
https://t.co/7uf5fAHiHY
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Can we tell whether a bacterial strain is sensitive or resistant to an antibiotic in 30 minutes, with a single image? Ribosome phenotypes let us see intracellular changes associated with antibiotic resistance in 1 image. #antibioticresistance
https://t.co/7uf5fAHiHY
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Huge congrats to @johan_elf_ and his lab for the prestigious award and for developing this very promising technology for rapid detection of #AMR!
bbc.co.uk
The winning test rapidly detects whether bacteria are causing an infection and identifies the best antibiotics.
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