Lorenzo Brunetti
@BrunettiLab
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Associate Professor of Hematology @UnivPoliMarche. Husband of @GeorgiaColle, father of 👶🏼.
Ancona, Marche
Joined May 2012
Hematology X biophysics = new leukemia pathogenesis paradigm! Our collaborative work with @RibackLab on NPM1c-mutant leukemia is live @CellCellPress! Multiple oncoproteins form similar nuclear condensates that massively drive leukemia-gene transcription!
(1/10) How do diverse leukemia mutations converge on the same molecular program? In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).🫧
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@Gandhar_Datar joined the lab when the world was shutting down, having just gotten started with guidance from @therealDrGundry and @BrunettiLab, who then moved on in their careers. Tough work in isolation until @RibackLab joined @bcmhouston, when informal chats got us thinking
(10/10) Thank you to everyone in the @RibackLab and @Goodell_Lab, especially to @sciencyelmira, for this amazing work, and to @theNCI, @CPRITTexas, @LeukemiaRF, Searle Scholars, Ted Nash Long Life Foundation, and @BCM_MSTP for essential funding support.
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Calorie restriction + aerobic/resistance #exercise is the winning combo in older adults with #frailty & #obesity: it improves body composition & insulin secretion. CNTF & IGF-1 might play a role! Grateful to @ESPENorg & @EASDnews Rising Star grants
clinicalnutritionjournal.com
Obesity exacerbates age-related changes in metabolic and physical function. The effect of distinct exercise modalities combined with diet-induced weight loss on insulin secretion in older adults with...
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Excited for our session on critical trial appraisal here at #EHA2025 in Amber 7&8 - @Capt__Kirkwood on randomisation - @ComeBommier on surrogate endpoints - me on postprogression care & overall survival - Fabio Efficace on patient reported outcomes #lymsm
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A/Prof @Capt__Kirkwood give us some great examples from within haematology of the importance of randomization & types of bias that can crop up in its absence (and occasionally in its presence!) #EHA2025 @young_eha
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Full room at the second session of YERM, chaired by @BrunettiLab and Alyssa Cull. Starting with @Nina_CabezasW lecture showing very cool data on the crosstalk between the HSC/bone marrow and the heart #EHA2025
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Dr Stefano Rivella @ChildrensPhila with the first session on #erythroppiesis. Join us in Brown Hall 2! #EHA2025 #YoungEHA
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Face-to-face meeting of the @young_eha committee, today in The Hague (NL) ! Lots of ongoing and future projects to serve young hematologists and help them achieve their full potential. You wanna be part of this adventure ? Please apply on the @EHA_Hematology website !
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Before you go on Xmas holidays remember 👇👇👇 Deadline for abstract submission to join us at #EHAReCon2025 in Malaga on March 17-20 is January 8th !! I will be chairing the session on Transcripitional control with this fab lineup of speakers 🤩 @young_eha
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1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in @NatureCellBio! https://t.co/3lIKztpOdg. 🧵 below:
nature.com
Nature Cell Biology - Kodali, Proietti et al. report that increased numbers of P-bodies in leukaemia cells account for sequestration and prevention of tumour-suppressive mRNAs from being...
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Our team @SCICambridge is expanding and we have now a very exciting opening for a Laboratory Research Technician/Assistant!!! More positions to be announced very soon. Help us spread the word 👇👇🔬🔬 https://t.co/U4qdvpvFWx
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Today, at TLH, we summarise a decade of hard work. We wish to thank all colleagues, patients and relatives, who helped us during this amazing journey. https://t.co/CIzVqbLH3m
thelancet.com
Chimeric antigen receptor (CAR) T cells have transformed the way that multiple haematological malignancies are managed. In the EU, six products manufactured by four marketing authorisation holders...
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"We are convinced that #academic CAR T-cell therapy will play an increasingly important role in cancer therapeutics... It would be unfair to leave our patients to their own devices when there is so much we can do for them" In Focus #CARtx @hospitalclinic
thelancet.com
Chimeric antigen receptor (CAR) T cells have transformed the way that multiple haematological malignancies are managed. In the EU, six products manufactured by four marketing authorisation holders...
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We are proud to have had you as our Chair @MandyNLauw! Thank you so much🙏🏼 for all your hard work advocating for the role of #YoungEHA🌱 in @EHA_Hematology and #earlycareer professionals in #hematology, and look forward to continue your great work with our new Chair @drnborges !
#EHA2024 was a special #Congress! Presenting 2 lectures, but above all my last one as Chair of @young_eha🌱 Such a rewarding experience representing the #earlycareer community. Special thanks to #committee friends,@EHA_Hematology office & Board🙏🏼 #future of #hematology is bright!
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Lots of #MRD studies presented at #EHA2024 Many investigators consider MRD as a surrogate endpoint, although not validated in many indications. Please read/share this review. Might help understand concept and current evidence. Agree @VPrasadMDMPH ? https://t.co/Y7YXReNTU5
ashpublications.org
Surrogate end points are markers that can be measured early which correlate with long-term outcomes to allow more rapid assessment of efficacy in clinical
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#EHA2024 was a special #Congress! Presenting 2 lectures, but above all my last one as Chair of @young_eha🌱 Such a rewarding experience representing the #earlycareer community. Special thanks to #committee friends,@EHA_Hematology office & Board🙏🏼 #future of #hematology is bright!
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An entire session dedicated to #palliativecare at #EHA2024. Proud of what we have achieved with the @young_eha committee! 🌱@EHA_Hematology
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Just got a coffee at #EHA2024 (thanks @sanofi ) and I was told I was the first person to ask for a coffee in a reusable cup. So come on everyone, bring your own cups next year to reduce waste and create a more sustainable congress ! @young_eha @EHA_Hematology
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