Today marks 3 big events: finishing residency, launching my lab @MountSinaiPsych @SinaiBrain, & receiving my 1st R01: @NIMHgov $4.2M BRAINS Award! Here’s to kicking off new beginnings + a warm welcome to my lab manager @sam_mbp_, grad student @emma_andraka & the growing team!🧠🐁

RT @SinaiBrain: Huge Congratulations to @neuromano, Orna Issler, @ScottRussoPhD @EricJNestler @BrianMSweis, et al. @IcahnMountSinai @Mount….

RT @MountSinaiPsych: A traditionally overlooked type of RNA plays an important role in promoting resilience to depression, but only in fema….

This speaks to the importance of cross-species research that is constantly forward & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in #psychiatry🧠

+ evidence that sensitivity to sunk costs & change-of-mind regret stem from a shared value function related to negative rumination & stress susceptibility. Congrats @neuromano @EricJNestler @ScottRussoPhD & team @IcahnMountSinai @SinaiBrain @MountSinaiPsych @ScienceAdvances 🧠6/6.

Here, we found LINC00473 in mPFC specifically altered change-of-mind decisions in female mice only, by enhancing sensitivity to sunk costs and how much re-evaluating recent mistakes influenced future choices. This is the 1st demo of non-coding RNA playing a role in cognition 5/6

Our collaborators recently found levels of the non-coding RNA LINC00473 were reduced specifically in mPFC 🧠 of women but not men diagnosed with MDD, based on post-mortem human 🧠 tissue studies. Expressing LINC00473 in mPFC promotes resilience to stress in female mice only. 4/6

Women are 2x as likely to develop depression than men. MDD can manifest w/ different symptoms b/t sexes, including alterations in negative rumination on the past. Combining clinical questions, behavioral neuroscience, & translational #neuroeconomics, we dove into this deeper. 3/6

We found striking sex differences in change-of-mind choices, but not initial value-based judgements, in 🐭 working for food rewards of varying costs (delays ⏰) & preferences (flavors 🧀🍌🍫🍇) on our neuroeconomic foraging task, Restaurant Row, while on a limited time budget 2/6

New paper!🚨📝. Paper: Press release: How the 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however🧵👇1/6.

RT @denisejcai: What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope!. Our new Miniscope2C is a dual-channel, open-source….

RT @morishih: Excited to share our review with our PhD student Ayako Kawatake-Kuno @SinaiBrain just out in @npp_journal . "Impact of early….

RT @AJIAorg: Physician-scientists turn lab breakthroughs into lifesaving treatments & make up a high portion of @NobelPrize, @LaskerFDN win….

RT @shlomitbeker: Hello, I’m looking to hire a post doc, to work on exciting projects on cognitive neuroscience of developmental disorders.….

RT @EngelTatiana: Our new paper with @chrismlangdon is just out in @NatNeuro! We show that high-dimensional RNNs use low-dimensional circui….

Conrgats @ScottRussoPhD, Tony, @neuromano and team!!!! @SinaiBrain.

RT @elisa_xu_: 🧵1/ Does depression recovery rewire the mind-body connection? Our latest from the Nash Family Center for Advanced Circuit Th….

RT @ProfBootyPhD: This is a really fascinating and important paper, on the mechanism of neurodegeneration in Huntington's disease. I often….

RT @GDunnArt: Aligning microetched plates before cutting them down to size. The margin of error in the microscopic etched mirrors is single….

RT @SaraMederos_: Thrilled to see our work published in Science today! Grateful for the opportunity to collaborate with an amazing team at….

RT @xiaosigu: Super excited to share this finding that just came out today in @NatMentHealth led by the @_SarahBanker, where we show import….