Bram De Laere
@BramDL
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Biochemical engineer, PhD medical science @karolinskainst and @ugent, #ProstateCancer, #LiquidBiopsy & @ProBioTrial researcher. Views are my own
Ghent, Belgium
Joined November 2016
Privileged seeing the @ProBioTrial published in @NatureMedicine . My sincerest gratitude for all the dedicated doctors, nurses, lab personnel, trial managers, and most importantly, the patients who made this possible🙏. Thank you @komop_tgkanker for making ProBio possible in🇧🇪.
🔥📢 The first results from the @ProBioTrial have been published in @NatureMedicine 🚀🌟. ARPIs outperform taxanes in metastatic #ProstateCancer: an outcome-adaptive randomized platform trial 🌟 [1/10].
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These findings could refine #PersonalizedMedicine and patient stratification in perioperative MIBC management and inform trials of FGFR inhibitors or alternative therapies. 🔍🎯🧬 . 👉check out the full study in @ESMO_Open: 5/5
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📉 CDKN1A mutations weren’t tied to NAC response but were linked to worse survival outcomes — hinting at prognostic value regardless of molecular subtype. #Biomarkers. 4/5
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Conversely, FGFR3 mutations were associated with poor response and inferior recurrence-free and overall survival — adding weight to growing evidence these patients may benefit from alternatives to NAC. ⚠️ #BladderCancer #FGFR3. 3/5
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Using a targeted sequencing approach on 110 MIBC patients, we found focal amplifications on chr6p22.3 — particularly E2F3 and SOX4 — were linked to pathologic response and no recurrences after 5 years. 📈 #Genomics #UroOncology. 2/5
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🚨 Our latest study in @ESMO_Open unveils key genomic alterations that could predict treatment response and outcome in #bladdercancer #MIBC patients receiving neoadjuvant chemotherapy (NAC) before cystectomy. 🧬🧪 #precisiononcology . 👉 1/5
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RT @EdmondMKwan: On the eve of #ASCO25, I am delighted to share results from the correlative analyses of the @ANZUPtrials phase II TheraP s….
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RT @piet_ost: @medoncodoc @DrSpratticus But if you ask the companies @Merck to provide drug for a biomarker selection trial like @ProBioTri….
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Proud to share the latest insights from the @ProBioTrial . Prognostic Value of the Circulating Tumor DNA Fraction in Metastatic Castration-resistant #ProstateCancer .🩸🧬. Full text available on @EurUrolOncol :
🚨 New Study Alert! 🚨. What if a blood test 🩸 could infer prognosis in advanced prostate cancer? Our latest #ProBio trial study reveals the prognostic power of circulating tumor DNA (ctDNA) 🧬 in #mCRPC. A thread 🧵👇 #CancerResearch #ProstateCancer. [1/8]
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RT @ProBioTrial: 🏅Secondary result:. We found a linear relationship between ctDNA 🩸 levels and outcome: . 📉 Every 10% increase in ctDNA fr….
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RT @ProBioTrial: 🏅Key result:. 🧬🩸 Compared to those with detectable ctDNA, men with undetectable ctDNA had . ➡️a 60% longer time before tre….
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RT @ProBioTrial: 🚨 New Study Alert! 🚨. What if a blood test 🩸 could infer prognosis in advanced prostate cancer? Our latest #ProBio trial s….
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RT @StrijbosMichiel: Important work from the ProBio team! Proud to be a contributor. #probio #prostatecancer .@BramDL @piet_ost @ReneeBulti….
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RT @urotoday: AR pathway inhibitors vs taxanes in #mCRPC #ProBio trial. @BramDL @ugent joins @zklaassen_md @GACancerCenter to discuss the #….
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A privilege to discuss our 🩸🧬 biomarker-driven @ProBioTrial together with @zklaassen_md . Thank you @urotoday for the invitation 🙏🏻. ➡️Visit or @ProBioTrial for more info!.
AR pathway inhibitors vs taxanes in #mCRPC #ProBio trial. @BramDL @ugent joins @zklaassen_md @GACancerCenter to discuss the ProBio trial, a groundbreaking platform study in metastatic prostate cancer. Findings show that AR pathway inhibitors often outperform taxane-based chemo in
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The very talented Dr @Sj0mpie about to embark on a new journey in his academic career. It has been a privilege to mentor you the past 8 years and advance #ProstateCancer research!.
There are a lot of people to thank because a PhD isn't a journey you travel alone. First, my jury members to critically assess my work (specifically @AdamSharpMedOnc for the great discussion)
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RT @piet_ost: Don’t forget the @ProBioTrial is an investigator-initiated trial! Crazy level of commitment of everyone involved.
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RT @ProBioTrial: Meet the @ProBioTrial consortium: healthcare professionals from 🇸🇪🇧🇪🇳🇴🇨🇭specialised in the treatment of men with metastati….
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