Dr. Brianne Barker
@BioProfBarker
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Teach and mentor undergrads at #DrewU. Fascinated by battle between viruses and the immune system. #TWiV and #Immune podcaster. 1x Jeopardy champ. She/her
Madison, NJ
Joined April 2012
Was just looking at the @CellCellPress Table of Contents in my email and was baffled when I read the title of this paper. Then I realized that the second word was not “poutine”
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Also “Are there any pathogens that have ubiquitin inhibitors to evade Class I?” The students were really on fire today.
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Another question today (and yes I know the answer to this one but I was still impressed by the question): wait, so if a self-protein got an amino acid change from a mutation like what would happen in a cancer cell, would that now be presented and act as a foreign antigen?.
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Another student came to my office after class to talk more about viruses and Class I. In part of our conversation, I suggested he look at @JonYewdell ‘s work on PubMed and he is so excited to spend the afternoon investigating some papers.
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Do any MHC Class II molecules with CLiP make it to the cell surface in a normal individuals? If so, are they recognized by T cells? Are there any microbes that have a CLiP mimic peptide to evade Class II presentation?.
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Some of today’s fantastic questions (admittedly all answerable by thinking about pathogens as containing many epitope peptides or by thinking of MHC molecules presented by a cell as a population but cool nonetheless…).
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Today’s question: Do other animals have autoimmunity? What are some examples/what are they like? (My answer was yes but I didn’t know examples).
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From earlier this semester: If someone has a severe bone break, will they have self reactive B cells leak out of the bone marrow before they can go through central tolerance, putting them at increased risk of autoimmunity?.
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My @DrewUniversity undergrads taking Immunology are asking some FANTASTIC questions this semester, so I thought I would start a thread for Immunologists to ponder and/or crowd source answers. #DrewU.
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RT @BrodinPetter: Amazing to join @profvrr @stephanielangel @CindyLeifer @BioProfBarker to talk sex-hormones & immunity, Life history theo….
microbe.tv
Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men).
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Dear Mammoths: I feel you. Each spring, it feels like hay fever will wipe me out too.
Hay Fever Helped To Wipe Out Mammoths In Post Ice Age Ecosystem, Study Claims.
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My Fall 2024 Immunology Course has started and I finally worked out my tech issues so you can follow along here:
youtube.com
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Just figured out that the lecture videos I have been making this semester (aka Immunology Lectures 1-5 so far) have not been posting to YouTube like they are supposed to and are ending up somewhere in the ether. Awesome.
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A definite perk of living in the future: can stream all the top college field hockey games from my couch. A highlight of my fall. Also, Go @DukeFH!.
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Went with same arm based on my memory of our discussion of @victora_lab’s work on #Immune and GC responses. Have also seen the earlier study that someone else mentioned here…and realistically, I probably over thought it.
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At CVS getting some vaccines. Pharmacist says I have to decide on arm while he preps the vaccine. Don’t think he realized he was talking to an immunologist who would put farrrrr too much thought into it. (What about that paper that said…).
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Also, as I get ready for being all Ms. Frizzle while delivering this lecture (How can you teach “Cells and Organs of the Immune System” without props?), I seem to be short a basophil. Perhaps this will help my allergies
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