Bin Yu
@BioIntelligeNet
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Postdoc at Caltech; UCSD, U-DUB (UW) alumni
Pasadena, CA
Joined November 2021
š§µ1/ Excited to share our new paper: "Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimerās Disease" We built a single-cell multi-omic atlas (DNA methylation + 3D genome) from AD and control brains. Paper:
biorxiv.org
Alzheimerās disease (AD) is the most common neurodegenerative disorder, yet the molecular mechanisms underlying its regionā and cell-type-specific pathogenesis remain poorly defined. Here, we...
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Excited to share that the main part of my PhD thesis is now published in @ScienceMagazine! I am grateful for my amazing mentorās @takaki_komiyama guidance and the contributions of all co-authors!
Our new paper is out in Science. We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change. Congrats to Bin and the team! https://t.co/aZiXE1cNXh
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Today in @ScienceMagazine: How do our brains bring our attention on one sense over another? UC San Diego researchers have discovered the group of neurons responsible, with implications for various health disorders and AI research. https://t.co/ZUhKnPERI2
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Thrilled to share my postdoc work from @takaki_komiyama lab, showing how motor learning reshapes thalamic influence on motor cortex to enable learned movements. Hats off to our collaborators and co-authors for their incredible contributions! https://t.co/CvU6DkPtz7
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Our new paper is out in Science. What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons. Congrats Jake! https://t.co/uNdopSBrvw
science.org
Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of...
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New paper led by @S_Blumenstock shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntingtonās disease mice. A great collab with @IrinaDudanova
biorxiv.org
Huntingtonās disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral...
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663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that she left us. https://t.co/hEbu4OfH1E
biorxiv.org
During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated...
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University of Washington biochemist David Baker has won the 2024 Nobel Prize in Chemistry for his pioneering work designing new proteins that can neutralize viruses, target cancer cells, and more. Read more from @uwmedicine: https://t.co/PU7AM1ETvA
#NobelPrize #GoHuskies
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton āfor foundational discoveries and inventions that enable machine learning with artificial neural networks.ā
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I am excited to announce that a part of my thesis work with @takaki_komiyama is out on bioRxiv! Summary š§µā¬ļø. Thanks to all the co-authors' contributions!
Our new paper by @BioIntelligeNet showing that olfactory bulb-projecting cholinergic neurons enhance odor representations in a context- and modality-specific manner https://t.co/21F3nyBOvq
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Excited to share our latest research published in @Nature! We explored how working memory representations evolve and stabilize with practice, using simultaneous volumetric imaging of more than 73,000 neurons. Big thanks to my amazing team and collaborators! Special appreciation
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A bit late announcement on twitter: I will move to šļøFloridaš next month to open my lab as an assistant professor @UFScripps My lab will study decision making, RL, number sense, autism using VR tasks for mice. I am recruiting postdoc/student/tech!!! Email or DM me if interested.
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Super proud to share that Oscar Arroyo, a @UNC_GMB PhD student in my lab has been awarded a prestigious HHMI Gilliam fellowship. We are both looking forward to working with #GilliamFellows program to promote inclusive graduate training. Congratulations, Oscar!!
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Thrilled to share our latest work from @JoeEcker lab, using cutting-edge snmC-seq3 and snm3C-seq technologies to generate 301,626 methylomes and 176,003 mC+3C multiome profiles from 117 dissected regions throughout the adult mouse brain. (1/n) https://t.co/APlIJSW7VP
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āMy advice to grad students and post-docs is to have a secret project. Donāt tell anyone about it, especially not your advisor.ā šš
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It is with great sadness that we mark the passing of Krishna Shenoy. He was a pillar of our community, a brilliant scientist and a beloved mentor and colleague. We share our condolences with Krishnaās family, trainees and colleagues. Details to come on a planned memorial service.
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Monday morning 2 komiyama lab posters! P14 āAdaptive top-down control of sensory gain by long-range cholinergic projections to the olfactory bulbā by Bin Yu @BioIntelligeNet.
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We are recruiting postdocs. If you are coming to the SfN and want to chat, please reach out. Motor learning, olfaction, decision making.
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