New organelle uncovered by in situ #cryoET: the #hemifusome, a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do. #CryoET #MembraneBiogenesis #Organelle. 🧵1/5

RT @NEIDirector: Meet the ‘hemifusome’:. A newly discovered vesicular organelle complex with a unique membrane topology. Could it play a ro….

RT @BrianRoemmele: “Scientists discover unknown organelle inside our cells”. Each new discovery changes how we perceive pharmaceuticals and….

5/5. This study was made possible by a fantastic team: @amirrasoultav and @HuShiqiong @NIH and @sehamebrahim @UVA.

4/5. We propose an ESCRT-independent mechanism for intraluminal vesicle and multivesicular body (MVB) formation. Via PND-driven vesicle generation, hemifusion, and internalization, hemifusomes act as hubs for building complex MVBs - no ESCRT machinery required.

3/5. Hemifusomes can exhibit lens-shaped hemifusion structures embedded within vesicle bilayers, mimicking "dead-end hemifusion" state from mathematical models. These are not fleeting intermediates, but long-lived structures with implications for protein and lipid sorting.

2/5. How do hemifusomes form? Not by canonical fusion alone. We propose a novel vesicle biogenesis pathway:.- Cytoplasmic proteolipid nanodroplets (PNDs) initiate the formation of hemifused vesicles.- These structures then remodel into hemifusomes

RT @sehamebrahim: From stem cell to structure-.This human colonoid shows the self-organization of intestinal epithelial cells in 3D—nuclei….

RT @sehamebrahim: 🧫 A gentle reminder that your gut is an actual work of art. #FluorescenceFriday #BeneathTheScope

RT @RockefellerUniv: Scientists in the @Alushin_Lab have figured out how cells build a structure that lets them migrate. Unpacking these “f….

RT @wonderofscience: A spectacular sight 1225m (4019 ft) beneath the waves off Baja California as EVNautilus encounter the amazing Halitrep….

RT @ben808080: Our latest paper is out and we have just released an update of CryoVesNet code for automatic segmentation of synaptic vesicl….

RT @bcarra2: First short article on the CZII CryoET Data Portal: .Comments/feedback welcome.

RT @Alushin_Lab: Pleased to present our latest work, where we show that the cell-cell adhesion protein afadin coopts mechanically-regulated….

RT @Madam_Mito: Crosstalk between mitochondria–ER contact sites and the apoptotic machinery as a novel health meter: Trends in Cell Biology….

RT @embl: Scientists at EMBL Heidelberg and @UVA have discovered a new adaptation to starvation in yeast, in which ribosomes attach to the….

RT @jomaa_lab: Happy to share our little discovery with @SimoneMattei19 team on how ribosomes hibernate upside down on mitochondria during….

RT @biorxiv_cellbio: Cytoplasmic ribosomes hitchhike on mitochondria to dendrites #biorxiv_cellbio.

RT @EspenLab: Standing room only for the first ACB-Physiology combined seminar series given by Dr Ebrahim from @UVA. She educated us on how….

RT @HHMIJanelia: 🎉Congratulations to Janelia Research Scientist Andy Moore (@aaandmoore) on 2 honorable mentions in the 2024 #NikonSmallWor….