Harry Giles
@Beandoc2
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Nephrologist (kidney doc) with a passion for kidney advocacy and especially home dialysis
United States
Joined June 2019
If you want to grow your home dialysis program then do urgent start PD. Check out the @RPANephrology white paper out on doing just this. Retweet to your fellow nephs. https://t.co/CIkWco5aNX
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It is so cool seeing images of Rich standing on stage and presenting this It was only 15 years ago I sat in his clinic and we had little more than RAASi and fish oil for pts with IgA Nephropathy Now an explosion of therapies precisely targeting the mechanisms disease #KidneyWk
Presented at #KidneyWk: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. Full ORIGIN phase 3 trial results:
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I told you IV iron was safe and effective. Now we have a observational evidence (propensity matched study in about 15,000 pts with MRSA infections and 27,000 with pneumonia) that it may be beneficial.
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A step-by-step algorithm for the optimal assessment and management of hypertension among patients on dialysis ca. 2024 from @JASN_News @AgarwalRajivMD
#Nephpearls 👉 https://t.co/FYcUlEVPFN
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Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney InjuryThe BICARICU-2 Randomized Clinical Trial https://t.co/xkjxvcn9ko
jamanetwork.com
This randomized clinical trial examines whether sodium bicarbonate infusion decreases day 90 all-cause mortality for patients with severe metabolic acidosis and moderate to severe acute kidney injury.
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I learned injectafer (a version of IV iron) can cause severe hypophosphatemia in as high as 50-70% of patients because it increases intact FGF23, which is a hyperphosphorylated protein. My heme attending hated injectafer.
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Epoetin: From life-saving to dangerous therapy in dialysis 1989-2005 This is a clinical history of the 5th biologic protein approved by the FDA under the brand name EPOGEN. Use of epoetin had an immediately life-saving impact on management of anemia in CKD patients. 1/
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Nephrology is evolving fast—AI, new care models & Medicare updates are reshaping kidney care. 💡 RPA leads with advocacy, policy engagement & innovation. Stay informed and shape the future. 🔗 https://t.co/nu7UmHysem
#RPA #Nephrology
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Now online in @NDTsocial Eculizumab for rapidly progressive glomerulonephritis 🧐Eculizumab, by rapidly suppressing complement attack and inflammation during the active phase of RPGN, may serve as a promising add-on therapeutic agent. ▶️ https://t.co/XBNQKAEiMQ
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After the success of FLOW in the CKD DKD population exciting to see this encouraging data in ESKD GLP-1 RA use associated with: 📉 weight loss ⚖️ lower BMI 🪦 lower mortality 📜 higher chance of kidney tx waitlisting https://t.co/PBogYa5Yqt
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📢 New in CJASN: pooled analysis of all completed phase 2/3 RCTs in #IgAN 🔹 4 drug classes (steroids, B-cell, complement, non-immunological) 🔹 All ↓ proteinuria ≥30% 🔹 All improved GFR slope 🔹 Biggest benefit: B-cell therapies https://t.co/NZBl0kIKZQ
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That's definitely the best source in order to deeply understand acid-base in clinical practice. Highly reccomended. https://t.co/d4yzJ4IrYZ
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Decongestion Secrets ("ammo" for rounds): In a multicenter study of 283 acute heart failure patients, changes in renal filtration markers (cystatin C or creatinine) with aggressive diuresis were not associated with changes in markers of renal tubular injury (NAG, NGAL, or KIM-1)
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Pfizer discovered the antifungal fluconazole - a cure for candida infections and deadly fungal meningitis Pfizer discovered the tetracycline antibiotic which cures a wide range of infections Pfizer massively scaled up penicillin production and curing millions from infection
Congratulations to Pfizer on 176 years in business and still not a single cure. Zero cures, billions in profit.
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Are you using 0.9% NaCl or balanced salt solutions such as Lactated Ringer's or Plasmalyte to resuscitate your patients with DKA? This paper suggests that we should be using the latter. 🎩 tip to the authors. https://t.co/Sfr6vCn6le
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Fluid accumulation syndrome, a term coined by these authors, definitely sounds nicer than "drowning your patients." Either way, stop drowning your patients. 🎩 tip to the authors, including @Manu_Malbrain
https://t.co/Sfr6vCn6le
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I was today years old when I learned that HHD only started in mainland China in April 2020 https://t.co/5HnjqEh8P1
bmcnephrol.biomedcentral.com
Background Observational studies have shown home hemodialysis (HHD) to be associated with better survival than facility hemodialysis (HD) and peritoneal dialysis (PD). Patients on HHD have reported...
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🧵1/ Hypovolaemia is the most overdiagnosed concept in medicine. We say it reflexively — especially in sepsis. But here’s the uncomfortable truth: We can’t measure blood volume. We infer it. Often wrongly. Let’s unpack why that matters. 👇 #MedTwitter #FOAMed
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We use diuretics every day in the ICU. Prescribing them is never a one-size-fits-all approach. This paper reviews different strategies we can utilize with our patients. 🎩 tip to the authors! https://t.co/wtiQFg1wGN
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He begins by citing research that Americans pay less (on average) for unbranded drug than the OECD, and 90% of our Rx’s are generic. However, the research points out overall the US pays an astounding 278% more for drugs. There’s no justification for that, and Cowen knows that.
“Let me explain—to the president and anyone else curious—why [U.S. drug prices] are higher and why lowering, controlling, and otherwise browbeating down the prices of pharmaceuticals is a fool’s errand.”
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