Bajpayee Lab
@BajpayeeLab
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Bioengineering lab led by Dr. Ambika G. Bajpayee. Drug delivery to charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes.
Boston, MA
Joined June 2019
These key barriers include cartilage, the blood–brain barrier, the GI tract, the eye, and the skin, and the effects on PK and tissue transport. We also present engineering design principles to enhance EV targeting and overcome these barriers for more effective therapeutics.
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Our new review, led by Helna, which examines how extracellular vesicles (EVs) interact with key biological barriers, is online now! https://t.co/L7WCAtUbDC
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Encapsulation within alginate-core polymeric microparticles (AlgPLGA-MP) extended pain relief to approximately one week, while avidin surface modification further enhanced joint retention and shows promise for prolonging analgesic effects even further.
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We demonstrate that Neosaxitoxin (NSTX) is a potent analgesic for osteoarthritis (OA) associated pain but is limited by rapid joint clearance and short therapeutic duration when delivered as a free drug.
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We are thrilled to share our latest work led by @Henry2833884 titled “Extended osteoarthritis pain relief with neosaxitoxin using alginate-core polymeric microparticles” published in @nanoscale_rsc Link: https://t.co/pwCWF6D3iz
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Come see us at ICRS 2025 18th World Congress in Boston! Dr. Bajpayee and Helna Baby will present our works on Extracellular Vesicles (EVs) at session 1.1 elEVate Your Game of ICRS 2025 (Sat 10/11) #ICRS #Cartilage
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Congratulations to Dr. Timothy Boyer @Boyer_TL for successfully defending his doctoral thesis! Tim’s work has focused on designing cartilage targeting cationic fusion proteins for the treatment of OA. Tim is heading to Rush University for his postdoc! He will be missed very much!
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Congrats to the Authors! @billlhakim, @Boyer_TL, @ChakraSrirupa, and @AmbikaBajpayee. @NUBioE1 @cilsinstitute
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By combining experimental and computational approaches, we investigated the contribution of charge and hydrophobicity arrangement on cationic peptide’s intra-cartilage transport. We found that there is an optimum cationic peptide's residue configuration for cartilage targeting.
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We are thrilled to share our latest work titled "Spatial charge-hydrophobicity configuration modulates cationic peptide transport in cartilage," published in @BiophysJ Free access: https://t.co/OUQKwJHrCL
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Congrats to Tim on his first first-author paper, and co-authors Olivia Chao, @billlhakim, Luke Childress, @meslier_q (shoutout for first lightsheet image), and computational help from @MJchemist and Suhasini Iyengar. @AmbikaBajpayee @cilsinstitute @NUBioE1
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In collaboration with Dr. Ryan Porter at UAMS, we demonstrate Cationic Peptide Carriers (CPCs) target the deep layers of rabbit knee cartilage, even in inflamed joints, and can be utilized to substantially improve intra-joint retention of DMOADs.
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Calling all Disease-Modifying OA Drugs‼️ We are excited to share new work led by @Boyer_TL now published in @OACJournal on evaluating Cationic Peptide Carriers for drug delivery of DMOADs in an animal model of post-traumatic osteoarthritis. Free Access: https://t.co/vlyPxpvIzA
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Congrats to our fantastic @Northeastern students and faculty at the Academic Honors Convocation. https://t.co/l3rqbdLZiO
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Excited to share that an editorial was published on our recent paper by Dr. Chris Evans on IL-1RA delivery to chondrocytes via surface-engineered exosomes! Huge thanks to the editors @OACJournal for the spotlight! Check it out! https://t.co/J9f2b059Bn
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Meet us in Chicago! Bajpayee Lab is excited to share new work on cationic drug delivery for osteoarthritis treatment #SFB2025 @SFBiomaterials #DrugDelivery #GeneTherapy #OAtreatment
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We are thrilled to share our latest work on surface-engineered exosomes for sustained interleukin-1 receptor antagonist (IL-1RA) delivery to cartilage via electrostatic interactions, now published in Osteoarthritis and Cartilage! @OACJournal Check it out! https://t.co/rwGv6kcGwu
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Two Bioengineers Win Presidential Early Career Awards @AmbikaBajpayee
news.northeastern.edu
Ambika Bajpayee and Eno Ebong both received the prestigious award for their innovative work in bioengineering.
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We're excited to share our work at #ORS2025 - come chat with our folks about their latest research! @ORSsociety
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