The Babak Lab HK
@Babaklab
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Integrating chemistry, molecular biology and experimental oncology
Hong Kong
Joined June 2020
📸 Image generated using Sora by OpenAI. Article link:
science.org
A GPCR and a moonlighting transcription factor together drive metastasis in breast cancer.
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New in @ScienceMagazine: HOXC12 identified as a key driver of β₂-adrenoceptor–dependent invasion in triple-negative breast cancer. A potential new target to block TNBC progression. Link in the comments 👇.#TNBC #BreastCancer #HOXC12 #OncologyInnovation #CancerResearch
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📸 Image generated using Sora by OpenAI. Article link:
ai.nejm.org
Objective structured clinical examinations (OSCEs) are a critical but resource-intensive means of training medical students and assessing their clinical competence. The potential of artificial inte...
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New in NEJM AI: GPT-4 powered ASCE training outperforms traditional OSCE prep — higher scores, less stress, more realism for med students. Link in the comments 👇. #NEJMAI #MedEd #AIinHealthcare
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New in @Nature: 30-year study of 100k+ people finds plant-rich diets boost odds of living longer in good health. Link in the comments 👇. #HealthyAging #NutritionScience #PlantBasedDiet #Longevity #PublicHealth #NatureMedicine
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📸 Image generated using Sora by OpenAI. Article link:
nejm.org
Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system. In this phase 3, open-label, randomized tria...
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New in @NEJM: High-sensitivity troponin testing can quickly rule out MI in many chest pain cases — reducing unnecessary hospital admissions. Link in the comments 👇.#Cardiology #Troponin #HeartAttack #NEJM
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📸 Image generated using Sora by OpenAI. Article link:
science.org
In exclusive chat with Science, Loreen Willenberg describes remaining HIV-free even after immune-suppressing therapies for brain and lung tumors
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New in @ScienceMagazine:.Cancer therapies may unlock HIV remission. New cases suggest the immune system, under specific conditions, can suppress HIV without lifelong treatment. Link in the comments 👇.#HIV #CancerTherapy #Immunology #ScientificWednesdays
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New in @NEJM: HPV-related cancers remain highly preventable — but global vaccine access and uptake still lag. A call to simplify dosing, expand coverage, and close equity gaps. Link in the comments 👇.#HPV #CancerPrevention #PublicHealth #NEJM #ClinicalMondays
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📸 Image generated using Sora by OpenAI. Article link:
science.org
Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such...
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New in @ScienceMagazine:.Multimodal AI is revolutionizing biology — integrating imaging, omics & clinical data to unlock complex systems. A shift from prediction to discovery. Link in the comments 👇.#AI #Biology #MultimodalModels #Neuroscience #Genomics #MachineLearning
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📸 Image generated using Sora by OpenAI. Article link:
nejm.org
On the basis of phase 2 studies, trastuzumab deruxtecan was approved for patients with human epidermal growth factor receptor 2 (HER2)–positive metastatic gastric cancer or gastroesophageal junctio...
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New in @NEJM:.T-DXd improves survival vs. ramucirumab + paclitaxel in HER2⁺ gastric cancer (2L). OS: 14.7 vs 11.4 mo.ORR: 44.3% vs 29.1%.Manageable safety. Link in the comments 👇.#HER2 #GastricCancer #TDXd #Oncology #ClinicalTrials
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Still celebrating @JArakelyan28092 big moment — she's officially Dr. Jemma!.So proud of everything she's achieved 🎓.#TeamScience #womeninSTEM #academiclife
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📸 Image generated using Sora by OpenAI. Article link:
nature.com
Nature - Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
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New in @Nature: Tumor necrosis isn’t just passive — it’s driven by neutrophils! 🧬 NETs form clots in tumor vessels, trigger hypoxia, necrosis, and fuel metastasis. Targeting NETs may reduce spread. Link in the comments 👇.#Neutrophils #Metastasis #TumorMicroenvironment
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@NEJM 📸 Image generated using Sora by OpenAI .Article link:
nejm.org
Perioperative FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) is a standard therapy for resectable gastric and gastroesophageal junction adenocarcinomas, but recurrence rates remain hig...
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