Avraham Ashkenazi Lab
@AvrahamLab
Followers
464
Following
2K
Media
30
Statuses
893
The Ashkenazi Lab studies the cell biology of protein misfolding and neurological disorders.
Tel Aviv University
Joined May 2019
๐
Our article is now published๐: TMEM16F regulates pathologic ฮฑโsynuclein secretion and spread in cellular and mouse models of #Parkinson's disease. Aging Cell. @TAUMedFaculty @of_sagol
https://t.co/8J3jzVYh9P
onlinelibrary.wiley.com
Parkinson's disease pathology is associated with cell-to-cell transfer of the aggregate-prone protein ฮฑ-synuclein (ฮฑ-syn). Using patient genetics, murine, and cellular disease modeling, we reveal...
7
9
55
Thrilled to share that my postdoc reserach about #TDP-43 local synthesis in #ALS is now published in @NatureNeuro! Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models | Nature Neuroscience @LabPerlson More details in thread.
9
5
20
Korsten et al employ live cell imaging and expansion microscopy to show that nuclear polyQ aggregates associated w/ #HuntingtonDisease induce nuclear envelope (NE) blebbing & cause NE ruptures. https://t.co/jTMvjwghf4 ๐ Intermediate Filaments collection: https://t.co/3mHq5u2QLy
0
14
44
We had the honor of welcoming our dear friends to our campus today for an inauguration that made history! Read more about it:
I was proud to join @TelAvivUni in honoring the Gray Foundationโs extraordinary giftโled by the formidable Mindy and Jon Grayโto the Faculty of Medical and Health Sciences. This remarkable act of generosity will power breakthrough research and train future medical professionals,
1
7
13
Excited to share our preprint: "๐๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐จ๐ฆ๐ข๐๐ฌ: ๐๐-๐๐ซ๐ข๐ฏ๐๐ง ๐๐๐๐ฉ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ซ๐๐ฏ๐๐๐ฅ๐ฌ ๐ง๐จ๐ฏ๐๐ฅ ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ ๐ข๐ง ๐ก๐ฎ๐ฆ๐๐ง ๐ง๐๐ฎ๐ซ๐จ๐ง๐ฌ"
๐๐๐ข๐ฌ๐ข๐จ๐ง-๐ญ๐ซ๐๐ง๐ฌ๐๐จ๐ซ๐ฆ๐ฌ-๐๐๐ฌ๐๐ ๐จ๐ซ๐ ๐๐ง๐๐ฅ๐ฅ๐๐ซ ๐ฉ๐ก๐๐ง๐จ๐ญ๐ฒ๐ฉ๐ข๐ง๐ ๐ฎ๐ง๐ฏ๐๐ข๐ฅ๐ฌ ๐ก๐ข๐๐๐๐ง ๐๐๐ ๐ฆ๐๐๐ก๐๐ง๐ข๐ฌ๐ฆ๐ฌ! ๐งต Thread on ๐๐๐๐ (๐๐ฆ๐ถ๐ณ๐ฐ๐ฏ๐ข๐ญ ๐๐ณ๐จ๐ข๐ฏ๐ฆ๐ญ๐ญ๐ฐ๐ฎ๐ช๐ค๐ด ๐๐ช๐ด๐ช๐ฐ๐ฏ ๐๐ต๐ญ๐ข๐ด)๐๏ธ our deep-learning model trained with
1
6
28
Very excited to share the first paper from my lab. We engineered a new PTEN sensor that permits dynamic imaging in living cells. We showed that this allows to visualize PTEN activity with subcellular resolution in the intact brain. Now published in Nature Methods
20
40
271
A HUGE Cuervo Lab effort exploring sex and age differences of CMA activity was published in @NatureAging today! Check out the publication https://t.co/tenXmP08xF and the @EinsteinMed press release https://t.co/v42EzYt2uN !!
nature.com
Nature Aging - Using single-cell imaging of a fluorescent chaperone-mediated autophagy (CMA) reporter and RNA sequencing data, the authors present a resource on basal CMA activity across organs,...
4
29
92
Today we are saying goodbye to our amazing student Fatima Amer-Sarsour who will start her postdoc training at @Cambridge_Uni with an @EMBO Fellowship๐ ๐. We took a sunny break for a farewell picnic. Fatima, we will miss you! @TelAvivUni @TAUMedFaculty
2
1
20
Sometimes we also go off campus and leave our labs... We are all so glad to celebrate Professor Asaf Madi @madi_lab and Professor Avi Ashkenazi @AvrahamLab being promoted to Associate Professors. Friends, family and colleagues got together for special beer ๐บ๐บ๐บ
2
1
20
Now published the final version Thanks to our PhD student Tamar๐and collaborators. #Parkinson #neurotoxin @TAUMedFaculty @of_sagol
https://t.co/eCBDvkFdQG
0
0
1
Our recent study is out ๐ฅณ. Thanks๐, PhD student Tamar for this exciting research and to our collaborators. This is part of our ongoing effort to elucidate vulnerability mechanisms in #Parkinson's disease outside the brain supported by @CDMRP. https://t.co/jneebNSjSc
2
4
14
Some good news๐ฅณin these difficult times: today I got a call from my dean letting me know I got tenure and promotion to Associate Professor๐ thanks so much to my lab members, colleagues, mentors, and my family for all the support @TAUMedFaculty @of_sagol
26
12
255
Congratulations Stav ๐, our amazing PhD student for leading this study together with our clinical and pre-clinical collaborators @TAUMedFaculty @TelAvivUni
Is there a way to stop #Parkinsons disease at its source? TAU researchers discovered a potential new target for developing treatments for this terrible ailment, affecting nearly 10 million people worldwide. Read more: https://t.co/AIgJ9vl5Gx
1
2
13
More about our new paper๐: Protein variant presents a potential new target for developing effective treatments for #Parkinson's disease https://t.co/wT9vz6YSZ8 via @medical_xpress @TelAvivUni @of_sagol @TAUMedFaculty
medicalxpress.com
Researchers at Tel Aviv University (TAU) discovered a new factor in the pathology of Parkinson's disease, which in the future may serve as a target for developing new treatments for this terrible...
0
2
18
We are proud to welcome Prof. David Rubinsztein as an affiliated faculty member at the Faculty of Medical & Health Sciences!
0
1
9
Congratulations Stav ๐ our amazing PhD student for leading this project together with our lab team, pre-clinical and clinical collaborators. We found a new gene contributing to #alpha-synuclein pathology in #Parkinsonโs disease
0
0
4
๐ขOur Commentary on the exciting research by Africano et. al is out. @MolTherapy @CCHSNetwork @TAUMedFaculty. A drug candidate for a rare polyalanine disease targeting the protein quality control:
0
2
5
Celebrating a sad birthday of 5 years old redhead Ariel Bibas who is in captivity in Gaza with his family. Bring them home now!
1
3
3
Ubiquitin system mutations in neurological diseases: Trends in Biochemical Sciences
0
2
9