Thank X (Twitter) for providing us a nice platform to spread our scientific news. But we decided to stop maintaining our X account and move to Bluesky.

Another step in bringing ceramide lowering therapies to patients with muscle disease. Congratulations to Johanne, Ioanna, and @Tanes_Lima for your valuable contributions https://t.co/vZUWVGF3cb

We were selected again as a “Highly Cited Researcher” in 2024 by @Clarivate. Thanks to all graduates for the hard work that enabled our continued success!

Congratulations to Andrea Ablasser, Johan Auwerx @Auwerx_Lab, Gioele La Manno @GioeleLaManno, and Matthias Lütolf @TheLutolfLab, who have made @Clarivate's #HighlyCited2024 list! https://t.co/qoxehzyNTc

Researchers at @Auwerx_Lab (@epflSV) have discovered that inhibiting the ACMSD enzyme can boost vital NAD+ levels, reducing liver inflammation and fibrosis in MASLD/MASH. This could pave the way for new treatments https://t.co/OeSDtR53Oe

Une nouvelle piste pour lutter contre la stéatose hépatique

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Our work on the role of NAD+ de novo synthesis in MASLD is out in Journal of Hepatology! @JHepatology Inhibiting ACMSD boosts liver NAD+ levels and reduces fibrosis, inflammation, and DNA damage in both mice and human liver organoids. Paper:

Congrats to @YasmineJLiu & team for demonstrating ACMSD inhibition reduces liver inflammation and early fibrosis in MASLD! Boosting NAD+ and reducing DNA damage in the liver are key to its effects. Paper,

Following the exciting news of the 2024 Nobel Prize in Medicine awarded to Gary Ruvkun and Victor Ambros for their groundbreaking discovery of microRNA, particularly in the worm C. elegans, I’m thrilled to share a new resource we’ve just published at hashtag#CellReports! :D

Explore emerging research with field leaders @KeystoneSymp Mitochondrial Biology in Health and Disease, this January in Taipei! https://t.co/yoTFVCuD4D #KSMitochondria25

Explore emerging research with field leaders @KeystoneSymp Mitochondrial Biology in Health and Disease, this January in Taipei! https://t.co/HCSrpFTf7L #KSMitochondria25

An interview by CQFD about our latest work Comment la génétique influence-t-elle notre santé métabolique?

🧬🔬Our researchers at @epflSV developed a metabolic health score using diverse mice strains, uncovering key genetic factors influencing metabolic health. Validated in human data, this study paves the way for personalized MetS treatments.

Nos chercheurs ont développé un score de santé métabolique dévoilant des facteurs génétiques clés influençant la santé métabolique. Validée par des données humaines, cette étude ouvre la voie à des traitements personnalisés.

Li et al. derive a continuous biomarker for metabolic homeostasis, the Metabolic Health Score (MHS), which they find associated with 2 genetic loci in BXD mice, and identify TNKS and MCPH1 as modulators of MHS in human datasets @XiaoxuLi_8 @Auwerx_Lab

The work of @XiaoxuLi_8 and collaborators defines a simple continuous and composite trait, termed the metabolic health score, that is more accurate in defining metabolic homeostasis and predicting future disease incidence

Thanks to all the current and past collaborators which made this happen - #1 in Switzerland https://t.co/imbqjlOLfa

Alessia de Masi and colleagues identify with Cyclo-His-Pro (CHP), a compound that improves muscle function in mouse models of Duchenne Muscular Dystrophy and Sarcopenia. Anti-inflammatory and anti-fibrotic mechanisms underpin this effect of CHP.

Big thanks to Professor Johan Auwerx @Auwerx_Lab for the insightful talk on mitochondria & aging at @KispiZuerich. We enjoyed that you highlighted the power of mouse data to enable human health trajectories. Your expertise in metabolism and genetics has left us inspired 🧬