Tarek M. Ashkar (El-Achkar)
@AshkarLab
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Physician Scientist, Nephrologist. Interests: #AKI, #Uromodulin, Multiplex imaging & Spatial analytics, Immune mediated kidney injury. Investigator @KPMProject
Indiana, USA
Joined May 2017
Happy to contribute along with many other colleagues to the 2 Kidney papers bridging @KPMProject and @_hubmap that are just out today in @Nature and @NatureComms :.
nature.com
Nature - A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states,...
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Kudos to all the team @IUKidney and all the collaborators and especially the participant heroes from @KPMProject who made this work possible.
Kidney diseases are a leading cause of death in the U.S. They affect 14% of adults, often without knowing it. IU researchers are mapping kidney cell types to improve diagnosis and open the door to more precise therapies.
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Loss of THY1 and increase in PROM1+ PTs may be indicative of disease progression and can help stage kidney disease.Harnessing Spatial Biology- Protein and RNA.
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Our latest in @ScienceAdvances from a large collaboration through @KPMProject . We characterize a population of PTs in human kidney that express the regenerative marker THY1. THY1+ PTs are lost in kidney disease
science.org
The interplay in expression of the stem cell markers THY1 and PROM1 in kidney proximal tubules marks the timeline of disease.
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Very nice excited to see this work published and also the super well done editorial by @Vishal_D_Patel.
Kidney cells can protect themselves during injury, but the mechanisms were unclear. @AshkarLab & team @IUMedSchool now show oxidative stress induces an isoform of uromodulin that re-routes to the mitochondria to enhance energy production. View paper:
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Looking forward to this tomorrow!.
How do trillions of cells work together to form & maintain the human body? @AshkarLab & @sarahteichmann1 will guide you through 3D & 4D spatial imaging, uncovering how organs function, develop, & respond to disease. Join the discussion! #CellMapCrew
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Splice switching antisense oligonucleotide that enhance this splice Uromodulin variant can improve the course of acute kidney injury. Many thanks to all collaborators @IUKidney @KPMProject.
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Happy to share this work in @jclinicalinvest led by superstar Azuma Nanamatsu. We found a splice variant of Uromodulin directed intracellularly to mitochondria to enhance energy metabolism and protect TAL cells from injury.
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RT @LeicaMicro: From the 3D micro-environment of the kidney to 4D atlasing of human organs, explore how cutting-edge imaging & spatial tech….
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Way excited to be participate in this superb Spatial Biology forum! Should be a great discussion!.
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RT @_hubmap: Urine for a renal treat today & we're not being irrational! It is #worldkidneyday2025 & #PiDay, so it's time for a slice of ki….
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RT @AndreaLConroy: An exciting new paper showing elevated uric acid in severe malaria predicts short- and long-term mortality and cognitive….
nature.com
Nature Medicine - In two independent cohorts of Ugandan children with severe malaria, elevated blood uric acid was found to be common and linked to both acute and postdischarge mortality, as well...
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Want a hands-on virtual interactive workshop in kidney single cell and spatial transcriptomics? The IU O'Brien Center has a cool workshop!! 👇🔥. No matter your expertise level, you will find useful tutorials & amazing speakers!!.
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RT @G_GhajarRahimi: I’m thrilled to share my first-author paper has been selected for APSselect @APSPublications @AJPRenal . “Acute kidney….
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RT @AJKDonline: Sex, Acute Kidney Injury, and Age: A Prospective Cohort Study. . @GolestanehLadan @basalely @Ashkar….
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RT @rajmehrotra1122: Getting ready for Best of ASN Journals session Room 20B/C @JASN_News @CJASN @ASNKidney360 #KidneyWk
https://t.co….
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Thank you! @ASNKidney portfolio of journals has amazing leadership and a super bright future!!!!.
@AshkarLab outgoing Chair of ASN Pubs Committee. It is his vision that led to the creation of ASN Portfolio of Journals! Thank you for your service @ASNKidney @JASN_News @CJASN @ASNKidney360
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Great meeting and a big thank you to all the @ASNKidney journal editors and ASN staff. Superb portfolio under the leadership of @rajmehrotra1122! Great things ahead!.
The staff, the editors, and the Chair of Pubs Committee @AshkarLab that are leading the @ASNKidney Journal Portfolio to greater heights! Thank you all for another productive meeting!! @JASN_News @CJASN @ASNKidney360 @KidneyNews
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