Arutha K
@aruthak
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Clinical-oMx Lab Head, Frazer Institute, UQ. Scientific Director, QLD Spatial Biology Centre. (Views my own)
Brisbane, Queensland
Joined May 2009
Let's get behind this amazing collaboration between @XboxANZ @Xbox @CureCancerAu to raise vital funds for early career cancer researchers @UQMedicine @UQ_News @TRI_info @Qld_SBC! 💪❤️ #GamingForACure #CancerResearch #MakingADifference 🎮🔬👩🔬
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RT @JCO_ASCO: Response-Adapted Surgical and Radiotherapy De-Escalation in Resectable Cutaneous Squamous Cell Cancer Using Pembrolizumab: Th….
ascopubs.org
PURPOSEThe high rates of pathologic complete response (pCR) after neoadjuvant immunotherapy have generated interest for a risk adaptive surgical and radiotherapy-free management approach to reduce...
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Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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RT @NEJM: Images in Clinical Medicine: E-Cigarette– or Vaping-Associated Lung Injury . #Pulmonology #CriticalCare h….
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RT @AgingBiology: Hallmarks and mechanisms of cellular senescence in aging and disease.
nature.com
Cell Death Discovery - Hallmarks and mechanisms of cellular senescence in aging and disease
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RT @oncodaily: A Non-Invasive Approach to Monitor Dynamic Changes in Tumour and Immune Signatures in NSCLC - @aruthak . .
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RT @RManochakian: ‼️Today is #WorldLungCancerDay. It’s an “ERA OF #HOPE” for #Patients with #LungCancer. We celebrate the great progress,….
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RT @LukasValihrach: Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in….
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RT @LAGurwitch: #WorldLungCancerDay2025 It's my 5 year cancerversary this year. A great time to remind that anyone with lungs can get lung….
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🧩 Adaptive Lasso (ALasso) regression with the Stabl algorithm, a method developed by #SurgeCare @NatureBiotech, was used to determine feature selection (false discovery corrected). A four protein signature panel was found to be predictive of overall survival.
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Baseline proteomic signatures were predictive for response to immunotherapy, with elevated IL-6, IL-2RA, SSP1, CD200R1 and CCL19 in non-responders. Novel associations with response were seen for CD21, IL-24, AGER and CD276.
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Biomarkers of tumour recurrence after surgery included FCER2, FCRLA, SLITRK2 and COX7A2L. Plasma detectable proteins diverge from tumour tissue studies underscoring a need to understand circulating proteins for translational relevance.
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💥 Post-surgery samples had a reduction in pro-inflammatory cytokines such as IL-36G, and CLEC3B, and elevated mediators of wound healing such as SHC1 and THBS3. Check out the paper for more differential markers showing blood detectable changes with surgery.
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🚩We found cross platform correlation for key chemokine (CCL28, CCL17, CXCL2, CCL5), extracellular matrix proteins (MMP1) and angiogenesis (PDGFA, PDGFB, ANGPT1) markers showing a complementary strength in biomarker discovery.
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📍A high-plex panel designed by SomaLogic and a high sensitivity panel designed by Alamar Biosciences were used to probe samples from NSCLC patients before and after surgery and before and after immunotherapy.
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🐦🔥 Plasma proteomic offers a non-invasive approach to monitor dynamic changes in tumour and immune signatures. We profiled patients with non-small cell lung cancer (NSCLC) to generate signatures associated with treatment response and prognosis✨. 🫁🩸
researchsquare.com
Objectives. Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with limited biomarkers to guide surgical and immunotherapeutic intervention. This study aimed to...
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RT @nucleai_ai: 🎓Nucleai Academy returns this September!.Dr. Ettai Markovits shares findings from a study with UQ & Yale revealing a metabo….
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RT @HaoYin20: #EpigeneticAging.DNA Methylation Ageing Atlas Across 17 Human Tissues😎.(Sorry No blood vessels. 😣). Meta-analysis of 15k hum….
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