RT @JasmineNephro: 🫘Approach to proteinuria and hypertension on VEGFi therapy. @CKJsocial

🧬 Type III RPGN = Pauci-Immune RPGN. ⚔️ No immune deposits on IF (pauci = few).🔍 Most common cause = ANCA-associated vasculitis.🧪 IF: Negative.🔬 Biopsy: Crescentic GN + necrosis, no immune deposits.🧭 Clues:.🔴 Hematuria, ↓GFR, systemic signs (e.g., fever, weight loss).🛠️.

RT @SethiRenalPath: Membranous nephropathy has undergone a paradigm shift due to the discovery of unique MN antigens. MN has gone from idi….

🧬 Type II RPGN = Immune Complex–Mediated GN.🧫 Immune complexes deposit in glomeruli → inflammation & crescents.🔬 IF: Granular staining (IgG, IgA, C3 depending on etiology). 🧭 Clues:.🔴 Hematuria + RBC casts.📈 Rising creatinine.🧪 Moderate proteinuria (subnephrotic).🧾

RT @NatRevNeph: Pregnancy-associated acute kidney injury — consensus report of the 32nd Acute Disease Quality Initiative workgroup https://….

🧬 Type I RPGN = Anti-GBM Disease. ⚔️ Autoantibodies attack the glomerular basement membrane (GBM).🔬 IF: Linear IgG.🫁🩸 If lungs involved → Goodpasture’s syndrome.🧭 Clues:.🚀 Rapid Cr rise.🔴 Hematuria. 😮‍💨 Hemoptysis (if pulmonary hemorrhage). 🛠️ Treatment (start ASAP!):.💊

RT @NephJC: #NephJCshorts . ✂️🌱Cutting the renin-angiotensin axis from the angiotensinogen roots using RNA interference via zilebesiran. ✍️….

RT @hardik4u24: 🩺Diagnosis and Mx of AKI on immune checkpoint inhibitors?. 🔪When to biopsy?.💉 Steroid or spare?.💊Mycophenolate vs inflixima….

💡Your ICU Diuretic Playbook. 🚫 Albumin won’t rescue a failing loop diuretic. 💊 Start with loop diuretics, monitor response. 🧱 Hit resistance? → Use sequential nephron blockade (add thiazide, acetazolamide). ⚠️ Diuretic response ≠ volume status — it reflects tubular

🔬 Pigment Casts in AKI: Heme or Muscle?.On H&E, hemoglobin & myoglobin casts look alike—pink to brick-red, globular or rope-like. But stains tell the story:.🔹 Prussian Blue = degraded hemoglobin (not intact).🧪 IHC:.✔️ Hemoglobin+ → supports hemolysis.✔️ Myoglobin+ → supports

RT @hardik4u24: 🤔Did you know your gut bugs 🦠 may hold the key to healthy kidneys?🫘. Gut dysbiosis = 🔥↑Inflammation, ↑CKD risk.SCFAs = 💪🛡️p….

RT @edgarvlermamd: Peritoneal Dialysis (PD) Catheter INFLOW FAILURE #Nephpearls . ✅ Heparinized Saline 20 mL flush.✅ Heparin 500 units/L.✅….

RT @drpriyajohn: 📉 CKD-MBD is common in CKD and worsens with progression. 📈 FGF23, phosphate, PTH rise.📉 Klotho, Vit D fall.➡ Leads to bioc….

RT @Rheumat_Aravind: 🧵 “10 Renal Clues to Autoimmune Disease You Should Never Miss”. The kidneys often reveal the first signs of systemic i….

🧠 How does therapeutic plasma exchange (TPE) actually help in acute & acute-on-chronic liver failure?.🧪 This review explains the MOA:.🔹 Removes cytokines (IL‑6, TNF‑α), DAMPs, endotoxins.🔹 Clears ammonia, bilirubin, bile acids → ↓ encephalopathy.🔹 Replenishes

🧬 Adult-onset IgA Vasculitis (IgAV) — rare, often misdiagnosed, yet more aggressive than in children. 🩸 Presents with palpable purpura, GI symptoms, arthralgia, and often nephritis. 🧪 Renal involvement in up to 63%, with ESKD risk ~30%. 🧠 Histology overlaps with IgA