Two sides of hypertension: kidney-driven and beyond https://t.co/HqpPbpcq09 🆕 🆓 #HTN #BP #NephX #MedTwitter #IM

How the exposome drives hypertension—linking life’s exposures to blood pressure biology https://t.co/HqpPbpcq09 🆕 #HTN #BP #IM

🔥#Complement system: the silent orchestrator in #kidney #transplant 🧬Classical→ AMR, C-disease relapse 🌿Lectin→ IRI via DAMPs 💥Alternative→ Xeno & innate triggers ⚙️C3/C5 cleavage→MAC→injury 🛡️Regs: C1-INH, Factor H/I, CD46, CD55, CD59 🔗 https://t.co/3OI5YvFpvh #CKD

🧐NDT Insights on Regulatory T Cells: 🥳Celebrating the Nobel Prize in Physiology or Medicine 2025 ♥️To celebrate the 2025 Nobel Prize winners, NDT has selected papers on regulatory T cells, which prevent immune cells from attacking our own body 👇👇👇 https://t.co/v8R4NkPhs2

🔥#Complement in renal allograft injury— immune path of graft loss: 🧬#IRI→ Lectin (MBL/MASPs), DAMP–TLR → cytokines, NK ⚔️#TCMR→ C3a/C5a amplify T/B cells, Th1/Th17↑, Treg↓ 💣#AMR→ DSAs→ classical path→ C4d, MAC, VWF→ injury 🔗 https://t.co/3OI5YvERFJ #Tx #NephX #MedX

🔥#Klotho—the longevity molecule linking #CKD & cognition 🧬Deficiency → fibrosis, inflammation, ↓Vit D, ↓EPO, Wnt/β-catenin↑ 💊Boosted by SGLT2i, RAASi, mTORi, Vit D, PPAR-γ agonists 🧠Neuroprotective & anti-aging potential 🔗 https://t.co/4FEs6hsPsW #Nephrology #CKDMBD

🩺 Don’t Ignore a Rise in Serum Creatinine! Even a small increase — just 0.3 to 0.5 mg/dL — can mean your kidneys are under serious stress. It may reflect a 30–50% loss of kidney filtration capacity. ❌ Don’t think “It’s just 1.5” That “small” number could be your body’s early

🔥#KetogenicDiet in #CKD—not always “clean fuel” for #kidneys: 🍳Dyslipidemia→ ↑LDL, apoB, saturated/trans fats ⚡Acidosis→ animal protein load, ketone oxidation 💎Nephrolithiasis→ ↓urinary citrate, ↑oxalate, low hydration 🔗 https://t.co/5wcRfx5FXQ #Nephrology #Nutrition

🥤#KidneyStone prevention — diet that protects your #kidneys 👇 🔗 https://t.co/EB2CBXdydU #Nephrology #Urology

🔥#MRAs targets fibrosis, inflammation, albuminuria & endothelial dysfunction across heart, kidney & vessels besides BP control 💊Protective in non-diabetic CKD—reducing organ damage & arrhythmia risk. 🔗 https://t.co/SpjhQ363ky #CKD #Nephrology #CRS

💧#Urinalysis: The Liquid #Kidney Biopsy💧 #Urine is a window to the kidneys🫘 From white to purple, maple syrup to musty, and RBC casts to crystals—every hue, scent, and cell tells a story! 🤩Infographics by Dr @nephromythri 🔗 https://t.co/GS38iwCxj0 #Nephrology #Pathology

🩸 I²M² approach to manage anemia in HD-CKD: 🔍 Investigate – Hb, ferritin, TSAT, TIBC 💉 Initiate – IV FCM 15 mg/kg 📊 Monitor – Hb every 4 wk 🔁 Maintain – reassess iron profile q3 mo 🔗 https://t.co/UJ4M4nzV2i #CKD #Anemia #Nephrology #FCM #NephX #MedTwitter #IDA

💉 Iron Deficiency Anemia in HD-CKD: 🔹 Screen: Ferritin <200 or TSAT <30% 🔹 Treat: IV FCM 15 mg/kg 🔹 Maintain: 100–200 mg q2–4 wk 🔹 Monitor: Hb monthly, ferritin & TSAT q3 mo 🧠 Indian Expert Consensus 🔗 https://t.co/UJ4M4nzV2i #IDA #Anemia #HD #CKD #IJN #NephX #MedTwitter

💊bDMARDs & tsDMARDs in #RheumatoidArthritis: -TNF-α inh:Adalimumab, Etanercept, Infliximab, Golimumab, Certolizumab -B-cell:Rituximab -Co-stim:Abatacept -IL-6 inh:Tocilizumab, Sarilumab -JAKi:Filgotinib, Baricitinib, Tofacitinib, Upadacitinib 🔗 https://t.co/boUU0uuPrL #RA #IM

🔥IgA Nephropathy has 2 faces: 🩸Inflammation→ proteinuria, hematuria, crescents, rapid eGFR fall 🧱Fibrosis → slow decline, TIF/TA, minimal hematuria 🎯Tx: steroids, budesonide, iptacopan➝ SGLT2i, RAASi, DEARA 🔗 https://t.co/2Qsexmnhtg 🆕@NDTsocial #IgAN #CKD #Nephrology

🚨Preventing HF post-MI needs multidimensional care— 🔹Reperfusion, antiplatelets, lipid-lowering 🔹ACEi/ARB, β-blockers, MRAs 🔹SGLT2i in CKD/DM 🔹Lifestyle, rehab, tobacco cessation 🔹Early follow-up & GDMT if HF 🔗 https://t.co/EckswSBkU9 #Cardiology #HeartFailure #MI

🚨#Kidney #Transplant #Rejection Mx: 🫘 🔹#TCMR: High-dose steroids → escalate to thymoglobulin if no response/severe. Optimize immunosuppression 🔹#ABMR: Plasmapheresis + IVIG + steroids ± Rituximab/Eculizumab (per DSA/chronicity) 🔗 https://t.co/6s0Q4WdAZB #Nephrology #Tx

🫘 #ADPKD genetics: 🧬#PKD1 (~67%): truncating=severe, non-truncating=milder 🧬#PKD2 (~15%): later onset, slower course ➕Minor genes (<0.5–2%): ALG5/9, DNAJB11, GANAB, IFT140, NEK8 🔹Rare: ALG6/8, PKHD1 🔗 https://t.co/BuNB5WZvdY #Nephrology #Genetics #MedTwitter #NephX

🚨Not all kidney cysts = #ADPKD 🫘 Mimics include: 🔹Alport (COL4A) 🔹ADTKD (MUC1, REN, UMOD) 🔹ARPKD (PKHD1) 🔹Tuberous sclerosis (TSC1/2) 🔹VHL, NPH, Bardet-Biedl, HNF1B Accurate dx needs phenotyping + genetics. 🔗 doi:10.1053/j.ajkd.2025.05.010 #Nephrology #CKD #Genetics

🚨#APOL1 & Collapsing Glomerulopathy - 🔷Emerging Rx & 🔹Pathways: JAK-STAT ↑APOL1, ER stress, lysosomal autophagy, mito injury ⚡Na⁺ influx→podocyte swelling & death 🔗 https://t.co/Lo9pmOFyfw #Nephrology #MedTwitter