🎉 Our #GWAS of gestational diabetes in #FinnGen is now available on medrxiv! We disentangle the genetic relationship of GDM with Type 2 diabetes using new methods we think could be much more broadly useful. A brief thread 🧵 1/7 https://t.co/VEJISlCyXX

In 2018 we published a non-linear Mendelian randomisation (NLMR) study in @ObesitySociety and it is now clear the method we applied is deeply flawed, so in October we published a Perspective correcting it. A 🧵on the cautionary tale of NLMR https://t.co/GZ5D071dEZ

We’re excited to share a preprint on the cardiovascular impact and genetics of pericardial adiposity. Key findings in 🧵 below and all results at: https://t.co/MAaMuDdGJy. (1/n)

Understanding Complex Trait Susceptibilities and Ethnical Diversity in a Sample of 4,145 Russians Through Analysis of Clinical and Genetic Data https://t.co/yMlbfpZsOM #bioRxiv

Calling all computationally-minded #postdocs! Join us in studying the link between gut #microbiome, intestinal permeability, and #endotoxemia to explore #arthritis onset and activity. Plus, you'll work in #Finland, the happiest country in the world 🇫🇮 https://t.co/cCldcTRjfO

Pleased to share our latest preprint. We extended the SuSiE model originally developed by the @mstephens999 Lab to a cross-population fine-mapping method. Led by the talented @KaiYuan1990 with @hailianghuang @RyanLongchamps @AFPopgen + many others. https://t.co/RUWhfatwCh

Thanks to the many amazing people who were part of this important work! Elisabeth Widén, @dalygene, @APalotie, @raymondkwalters, @MattiPirinen, @mitja_kurki. And thanks to @SarnoffCardio. We are grateful for the @FinnGen_FI community, biobanks, and Finns who donated samples. 7/7

The findings pave the way toward understanding GDM and its role in the development of #T2D. More data is needed to further distinguish diabetes mechanisms acting predominantly in pregnancy that could be used to develop targeted interventions to prevent and treat #GDM. 6/7

GDM signal is enriched in brain cells and nuclei not seen in T2D, along with a more shared enrichment in pancreatic cells. Our novel loci that are more GDM-predominant highlight a potential role for glucose-sensing neurons that express the estrogen receptor. 5/7

Genetic features distinct from #T2D were found at both the locus and genomic level. We're able to classify GDM-associated loci into two categories, beginning to separate mechanisms affected predominantly during pregnancy versus those in T2D polygenic risk. 4/7

We conducted the largest genome-wide association study of #GDM to date, with 12,332 cases and 131,109 female controls in the FinnGen Study. We successfully identified 13 GDM-associated loci, including 8 novel loci. 3/7

#GestationalDiabetesMellitus (GDM) affects over 16M pregnancies yearly and increases the risk of Type 2 Diabetes (T2D). A genetic link is suspected, but genetic data is limited. #GWAS #GDM 2/7

Can a community-based social support program reduce MDD rates among adults in a high-stress environment? Learn more about the impact of social support programs on reducing depression in Nepal https://t.co/exaZwmPA1b

Excited to share our latest manuscript on complex trait fine-mapping across diverse populations! This is a collaborative effort across BioBank Japan @FinnGen_FI and @uk_biobank with mentorship from Hilary Finucane @dalygene @okada_yukinori. Here is 🧵 1/n https://t.co/lnRWRXjrTA

Really interesting read from @patrickaturley @SilviaHBarcell1 @leandroscarvalh that uses genetics as an epidemiological tool when considering how shifts in public policy can have have longterm effects.

New working paper with @SilviaHBarcell1 and @leandroscarvalh "The Effect of Education on the Relationship between Genetics, Early-Life Disadvantages, and Later-Life SES" https://t.co/ypbbmEk753

Former President Bush congratulates President-elect Biden on his win and says while Trump has the right to pursue legal challenges, the 2020 election was "fundamentally fair" and its outcome was clear https://t.co/6IrCIAveAy

This is it –– today is the last day to vote. If you haven't already, find your polling place at https://t.co/mKUaPPw7MV.