Such an honor to be invited to give the Keynote address at this year’s inaugural 2024 #UFWhiteCoat PhD ceremony! Congratulations to all the newly minted PhD candidates on this important milestone! #GoGators https://t.co/nYKnWS8hXh

Congratulations @rprobinpark! Excited for many more productive collaborations as we continue to expand our head and neck #CancerResearch footprint here @MoffittNews.

We are thrilled to have @rprobinpark continue his career @MoffittNews and look forward to many exciting research collaborations! #HeadandNeck #CancerResearch

👇Publication Alert: Simple Blood and Mouth Rinse Tests for HPV-Related Throat Cancer. Our @MoffittNews team explored new, less invasive ways to detect and monitor HPV-related throat cancer using two easy-to-collect samples: 🩸 blood (cell-free HPV DNA) 🦷oral rinse/gargles

The MOSAIC microscope by @ABCUCBerkeley is out! Congratulation to Gokul and all the authors @Eric_Betzig @futianming!! Check out those extravasating tumor cells!! Amazing technology! https://t.co/hN6MuS5U11

https://t.co/GUeBni9wfl

News from @AmelioLab: Advanced #SalivaryCancer and developing glands share common #p53 pathway regulation. Pro-tumorigenic FGFR2 distinguishes foetal development from high-grade MEC. https://t.co/8y4XpwKvMj

4. Finally, we used computational and molecular analyses of human and murine salivary MEC tumors to reveal that alternative splicing of FGFR2 distinguishes C1/M2-positive MEC tumors from transcriptional programs operational in normal fetal development.

3. We developed an autochthonous mouse model of salivary MEC in which expression of the C1/M2 oncogene is targeted to Krt14-positive ductal cells in the murine salivary gland and confirmed that C1/M2 expression coupled with Tp53 loss drives progression to high-grade MEC.

2. While C1/M2 fusion positive salivary MECs generally harbor wild-type p53, we observed progressive elevation in MDM2 expression levels according to tumor grade suggesting that post-translational loss of p53 contributes to disease progression.

1. We performed a comprehensive integrated analysis of gene expression data, which revealed that activation of developmental signaling programs is a hallmark of high-grade salivary MEC. These analyses also revealed common p53 pathway regulation in development and tumorigenesis.

While low-grade MEC tumors can be successfully managed with surgical resection, patients with high-grade tumors have limited treatment options. Thus, understanding the signaling mechanisms involved in progression is crucial for identifying novel therapeutic vulnerabilities.

Mucoepidermoid carcinoma (MEC) is the most frequently occurring salivary gland malignancy. This tumor type is characterized by a t(11;19) chromosomal translocation, which generates the oncogenic fusion CRTC1-MAML2 (C1/M2).

Thrilled to share our most recent @oncogenejournal publication co-led by @adelemusicant and @JuliaBCancerSci. This study highlights oncofetal reprogramming in salivary tumor development & progression. @MoffittNews @CancerBiol_PhD #salivarycancer🧵👇 https://t.co/TTfeoHSRoP

🎓 Big congratulations to Julia Billington, PhD @JuliaBCancerSci on the successful defense of her doctoral dissertation entitled, “An FGFR-p53 Developmental Signaling Axis Drives Salivary Cancer Progression”. Julia was mentored by @AmelioLab during her PhD. Well done Julia! 👏🏼

Scientists propose the Human Proteoform Project—an initiative to describe a complete set of protein forms expressed from the ~20,000 genes encoded in the human genome—as a critical next step in disease research. Read more on #NationalProteinDay: https://t.co/hAnD508Zyf

Respawn! Representing #Racing in the #Mazda MX5 Cup at INDYCAR St. Pete Gran Prix! @iRacing & @Mazda took me from Sim2Reality almost a decade ago, and I’m So Proud and grateful to have iRacing on the hood for the death match that is MX5 Cup, against a lot of you pro drivers!

Thrilled to share our story out in Cancer Cell, led by the amazing Kay Hanggi (now on the job market). We show that necrotic forms of cell death and the subsequent release of IL1a drives myeloid-based immune suppression in models of breast cancer. (1/11) https://t.co/7cafJW2KSQ

The Vaishnavi Lab is hiring a new RAII! Interested in learning more about mouse models of lung cancer? https://t.co/tQwQdBUIch Please RT! #lcsm #AcademicChatter

I was honored to be the keynote speaker today at @BioFlorida’s #BioFL24 conference. My talk covered how @MoffittNews is boosting biotech in the sunshine state, including our leadership in #CellTherapy and our new #SperosFL campus under construction in Pasco County, FL. Thank

Basic science session on #HPV in cancer today! Thank you to the @IPVSociety #IPVC2024 meeting organizers for the opportunity to share our work on #spatial #multiomics profiling of immune infiltrates in our preclinical model of HPV+ OPC. @MoffittNews #COMET @lunaphore #biomarker