https://t.co/xBivKM7PLJ

Comparative single cell analysis reveals complex patterns of cell type and cell signaling innovations at the fetal-maternal interface

New preprint! I’ve been thinking about genetic toolkits and convergent evolution.

Check out our updated single cell atlas of Nematostella, by @AlisonCole: https://t.co/sfoQPJldbW It was completely remapped on the new chromosome scale genome and gene annotation (PMID: 38092765), but also contains new data and analyses. Great work, Alison!

Thanks to funding by @FWF_at we will put worm snails in the limelight of evodevo and omics research! 2 fully funded PhD positions being announced soon. Feel free to spread the word and send inquiries directly to me if interested. 🐌🪱

#Jobs available: 3-year #PhD and #postdoc in our lab at @BioUHoh! We've got the infrastructure and now need the people. Very happy to discuss projects. Please RT widely! #DevBio #EvoDevo #Genomics #Insects #Evolution #GeneRegulation https://t.co/njlYo5RxEM https://t.co/tewWODzrcj

13 years ago this month, my son was diagnosed with brain cancer. I promised him that I would do everything I could to help kids with #ChildhoodCancer. It’s the only thing he asked us to do. Not to help him, but to help others. I would be grateful for a follow or a RT to spread

Medusozoans like the scyphozoan Aurelia undergo metagenesis from the asexual polyp to the sexual medusa. What are the changes in cell types? Check out our Aurelia scRNAseq atlas of this crucial body plan change:

Great summary of a cool project. Happy to have played a small part!

Regrettably, Daniel Thiel isn't on Twitter. But this is the result of 4 years of his postdoc work and our great collaboration during this time at the Jekely lab. We've identified numerous receptors in Nematostella and discovered many interesting things 1/n https://t.co/ArLGE2J7Uk

The #Aiptasia life cycle is closed! A prerequisite to settlement of larvae is actively hunting prey, not #symbiosis. Thus, carnivory likely is an ancestral feature in the cnidarian gastrula life stage:

Ctenophores or sponges? We identified chromosomal changes that support ctenophores as the sister group of all other animals. In @Nature w/ @beroe @DanRokhsar et al. Support from @MBARI_News @NSF @ERC_Research 🔗 https://t.co/bSf0hwJHwU

We propose the ectodermal muscle may be a novel anthozoan muscle cell type. The single cell data is housed on the UCSC @cellbrowser! Thanks to @UlrichTechnau and all co-authors for making this possible. 4/4

This convergence is driven by the expansion of a family of bHLH transcription factors, and subsequent recruitment of the fast-retracting gene module between germ layers. Using CRISPR to disrupt the ectodermally expressed paralog, we eliminate the ectodermal muscle cell type 3/4

We document an association between contractile speed and differential use of paralogous gene sets across the four principal muscle fields. We further identify transcriptomic convergence of the two fast retracting muscles derived from separate germ layers. 2/4

Fruits of a great collaboration with @TechnauLab and @PRHSteinmetz now available from Nature Communications: https://t.co/u1VzAMn17a In this paper we demonstrate the presence of both fast and slow contractile muscles in a sea anemone. Thread 1/4

Work from @BabonisLeslie shows a simple switch controls the development of two alternative types of stinging cells in the sea anemone Nematostella vectensis. @Whitney_Lab @CornellEEB https://t.co/LTLLxz2QTk

It was great working with @ItaiYanai and Tamar Hashimshony. I learned a lot! Thrilled to see it go public: Have a look and let us know what you think! If you like it, then maybe you will also see transparent public reviews, courtesy of @eLife. https://t.co/8tnQDJ0LN5 (3/3)

To consider these questions and more we generated an embryo- resolved single cell transcriptomic atlas of c.elegans development spanning the first seven cell cycles. We can identify every cell and reconstruct all founder cell lineages. What else would you ask these data? (2/3)

https://t.co/8tnQDJ0LN5 Have you ever wondered what the segmentation gene network is doing in non-segmented animals? Or how organisms with highly determinate development manages to segregate cell type identities? (1/3)